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High-fibre diet may protect against allergic asthma
New Scientist Eating a high-fibre diet could trigger changes in the immune system that protect against allergic asthma. Research in mice has shown for the first time that levels of dietary fibre, found in fruit and vegetables, can influence the balance of microbes … |
View full post on asthma – Google News
Condition: Allergic Rhinitis
Intervention: Drug: Doxazosin XL
Sponsors: University of Dundee; University of Dundee
Recruiting – verified September 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Scientists discover protein that helps trigger allergic asthma
HealthCanal.com The findings, published in the journal Science, could help develop more targeted treatments in the future. Allergic asthma is often marked by the symptoms of difficulty breathing in, wheezing and coughing, and can be trigged by different factors in the … |
View full post on asthma – Google News
The Independent |
Scientists discover protein that helps trigger allergic asthma
The Independent Allergic asthma is often marked by symptoms like difficulty drawing breath, wheezing and coughing, and can be trigged by different factors in the environment such as dust, mold or animals. Co-author David Corry explained that "asthma is part of a … |
View full post on asthma – Google News
Condition: Allergy
Intervention: Procedure: bronchofiberscopy
Sponsors: Centre Hospitalier Universitaire de Nice; Centre Hospitalier Universitaire de Nice
Not yet recruiting – verified July 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Medical Xpress |
Clues emerge to explain allergic asthma
Science News A common blood-clotting protein turns out to play a role in allergic asthma. The protein interacts with better-known immune system players already implicated in allergy, providing a missing piece of the biological puzzle underlying such respiratory … The pathway to asthma winds through toll-like receptor 4 |
View full post on asthma – Google News
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Inflammatory on and off switch identified for allergic asthma and COPD
EurekAlert (press release) Bethesda, MD—Japanese researchers have made a new step toward understanding why—and how to stop—runaway inflammation for both chronic obstructive pulmonary disorder (COPD) and allergic asthma. In a new report appearing in the August 2013 … |
View full post on asthma – Google News
The effect of omalizumab on ventilation and perfusion in adults with allergic asthma.
Am J Nucl Med Mol Imaging. 2013;3(4):350-60
Authors: Kelmenson DA, Kelly VJ, Winkler T, Kone MT, Musch G, Melo MF, Venegas JG, Harris RS
Abstract
Omalizumab promotes clinical improvement in patients with allergic asthma, but its effect on pulmonary function is unclear. One possibility is that omalizumab improves asthma symptoms through effects on the regional distributions of ventilation, perfusion, and ventilation/perfusion matching, metrics which can be assessed with Nitrogen-13-saline Position Emission Tomography (PET). Four adults with moderate to severe uncontrolled allergic asthma underwent symptom assessment, spirometry and functional pulmonary imaging with Nitrogen-13-saline PET before and after 4-5 months of treatment with omalizumab. PET imaging was used to determine ventilation/perfusion ratios, the heterogeneity (coefficient of variation, COV) of ventilation and perfusion, and lung regions with ventilation defects. There were no significant changes in spirometry values after omalizumab treatment, but there was a trend towards an improvement in symptom scores. There was little change in the matching of ventilation and perfusion. The COV of perfusion was similar before and after omalizumab treatment. The COV of ventilation was also similar before (0.57 (0.28)) and after (0.66 (0.13)) treatment, and it was similar to previously published values for healthy subjects. There was a non-significant trend towards an increase in the extent of ventilation defects after omalizumab treatment, from 5 (15)% to 12.8 (14.7)%. Treatment of moderate to severe uncontrolled allergic asthma with omalizumab did not result in a significant improvement in ventilation and perfusion metrics assessed with functional PET imaging. The normal COV of ventilation which was unaffected by treatment supports the hypothesis that omalizumab exerts its clinical effect on lung function during allergen exposure rather than in between exacerbations.
PMID: 23901360 [PubMed]
View full post on pubmed: asthma
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Inflammatory on and off switch identified for allergic asthma and COPD
Science Codex Bethesda, MD—Japanese researchers have made a new step toward understanding why—and how to stop—runaway inflammation for both chronic obstructive pulmonary disorder (COPD) and allergic asthma. In a new report appearing in the August 2013 … |
View full post on asthma – Google News
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Inflammation switch for allergic asthma, COPD found in leukotriene receptors
ScienceBlog.com (blog) Japanese researchers have made a new step toward understanding why—and how to stop—runaway inflammation for both chronic obstructive pulmonary disorder (COPD) and allergic asthma. In a new report appearing in the August 2013 issue of The … |
View full post on asthma – Google News