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Anti-TSLP antibody shows promise for treating allergic asthma
ModernMedicine Investigators divided 31 patients with mild allergic asthma into 2 groups: 1 group received 3 monthly doses of AMG 157, an anti-TSLP monoclonal immunoglobulin, and the other, placebo. They conducted allergen challenges on days 42 and 84 of the … |
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No Adjuvant Effect of Bacillus thuringiensis-Maize on Allergic Responses in Mice.
PLoS One. 2014;9(8):e103979
Authors: Reiner D, Lee RY, Dekan G, Epstein MM
Abstract
Genetically modified (GM) foods are evaluated carefully for their ability to induce allergic disease. However, few studies have tested the capacity of a GM food to act as an adjuvant, i.e. influencing allergic responses to other unrelated allergens at acute onset and in individuals with pre-existing allergy. We sought to evaluate the effect of short-term feeding of GM Bacillus thuringiensis (Bt)-maize (MON810) on the initiation and relapse of allergic asthma in mice. BALB/c mice were provided a diet containing 33% GM or non-GM maize for up to 34 days either before ovalbumin (OVA)-induced experimental allergic asthma or disease relapse in mice with pre-existing allergy. We observed that GM-maize feeding did not affect OVA-induced eosinophilic airway and lung inflammation, mucus hypersecretion or OVA-specific antibody production at initiation or relapse of allergic asthma. There was no adjuvant effect upon GM-maize consumption on the onset or severity of allergic responses in a mouse model of allergic asthma.
PMID: 25084284 [PubMed – in process]
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Allergic reactions to anisakis found in fish.
Curr Allergy Asthma Rep. 2014 Aug;14(8):455
Authors: Nieuwenhuizen NE, Lopata AL
Abstract
The food-borne parasite Anisakis is an important hidden food allergen. Anisakis is a parasitic nematode which has a third-stage larval form that infects mainly fish, and ingestion of contaminated seafood can result in severe allergic reactions. Symptoms experienced due to exposure to this parasite include gastrointestinal disorders, urticaria, dermatitis, asthma and even anaphylaxis. Accurate prevalence data of allergic sensitisation to Anisakis are difficult to estimate due to the lack of well-designed population-based studies. Current diagnostic approaches rely on the detection of serum IgE antibodies to allergenic proteins, which however demonstrate considerable immunological cross-reactivity to other invertebrate allergens. While exposure to this parasite seems to increase due to the increasing consumption of seafood worldwide, the immunology of infection and allergic sensitization is not fully understood.
PMID: 25039016 [PubMed – in process]
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Redox mechanisms in allergic asthma associated with disease pathogenesis
Healio Redox mechanisms of oxidative stress in allergic asthma played a “critical role” in disease pathogenesis and could be a therapeutic target, according to recent study results. Researchers conducted a literature review of PubMed for redox therapy … |
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Progress in allergic asthma research after ingestion of fruits
Phys.Org From health point of view, the presence of Alt a 1 in apparently healthy kiwis is important since Alternaria is described as a major cause of chronic asthma in children. These results suggest that patients allergic to Alternaria can suffer an allergy … |
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Interaction between 2 proteins can be responsible for allergic asthma after …
News-Medical.net Researchers at the UPM suggest that the interaction between two proteins can be the responsible for the allergic asthma episodes after eating an infected fruit. A research group of the Centre for Plant Biotechnology and Genomics (CBGP) of Universidad … |
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Allergy & Asthma Network Announces Free Webinar on Allergic Reactions to …
MarketWatch VIENNA, Va., July 10, 2014 /PRNewswire-USNewswire/ — Allergy & Asthma Network, a leading nonprofit patient education organization, invites you to join its "2014 Venom Allergy 101" webinar on July 24, 2014, at 7 p.m. EST. This webinar is perfect for … Allergy & Asthma Network, ALAA to increase awareness on life-threatening latex … Sports Breathing Issues – Asthma or Not? Is an Allergy Shot Worth It? |
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Sports Breathing Issues – Asthma or Not?
Allergic Living Q: My teenage son had a second spell of bad breathing during a school basketball game. Even when he stopped playing, it felt like somebody was sitting on his chest. Could this be due to asthma? Dr. Bassett: Your suspicions might be warranted … Is an Allergy Shot Worth It? Dedicated helpline to tackle allergies One Third of Bulgarians Suffer from Allergies |
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Allergic rhinitis underdiagnosed in Puerto Rican children with, without asthma
Healio Physicians underdiagnosed allergic rhinitis in more than 75% of children with asthma and an even greater number of children without asthma in Puerto Rico, according to study results. Researchers studied 547 children aged 6 to 14 years from March 2009 … |
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Sublingual Immunotherapy Reduces Symptoms of Asthma, Allergic …
HCPLive This systematic review examined the use of sublingual immunotherapy (SLIT) for allergic rhinoconjunctivitus and asthma in English-language studies searched throughout MEDLINE, EMBASE, and LILACS databases and the Cochrane Central Register of … |
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