Death after Asthma Attack Ruled a Homicide – CIproud.com

Death after Asthma Attack Ruled a Homicide
CIproud.com
Peoria County Coroner Johnna Ingersoll says 30-year-old Meredith Grube died in the ER of OSF St. Francis Medical Center on October 15, 2012 after an asthma attack. The report from the coroner shows things went awry at Grube's house in the 600 block of
Washington woman's death declared a homicideWashington Times-Reporter

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Programmed cell death ligand 2 regulates T(H)9 differentiation and induction of chronic airway hyperreactivity.

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Programmed cell death ligand 2 regulates T(H)9 differentiation and induction of chronic airway hyperreactivity.

J Allergy Clin Immunol. 2012 Nov 19;

Authors: Kerzerho J, Maazi H, Speak AO, Szely N, Lombardi V, Khoo B, Geryak S, Lam J, Soroosh P, Van Snick J, Akbari O

Abstract
BACKGROUND: Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying physiologic and immunologic processes are not fully understood. OBJECTIVE: The aim of this study was to determine whether T(H)9 cells develop in vivo in a model of chronic airway hyperreactivity (AHR) and what factors control this development. METHOD: We have developed a novel chronic allergen exposure model using the clinically relevant antigen Aspergillus fumigatus to determine the time kinetics of T(H)9 development in vivo. RESULTS: T(H)9 cells were detectable in the lungs after chronic allergen exposure. The number of T(H)9 cells directly correlated with the severity of AHR, and anti-IL-9 treatment decreased airway inflammation. Moreover, we have identified programmed cell death ligand (PD-L) 2 as a negative regulator of T(H)9 cell differentiation. Lack of PD-L2 was associated with significantly increased TGF-? and IL-1? levels in the lungs, enhanced pulmonary T(H)9 differentiation, and higher morbidity in the sensitized mice. CONCLUSION: Our findings suggest that PD-L2 plays a pivotal role in the regulation of T(H)9 cell development in chronic AHR, providing novel strategies for modulating adaptive immunity during chronic allergic responses.

PMID: 23174661 [PubMed – as supplied by publisher]

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Bronchial asthma ruled cause of death for Millington football player Dana Payne – Memphis Commercial Appeal

Bronchial asthma ruled cause of death for Millington football player Dana Payne
Memphis Commercial Appeal
Millington High football player Dana Payne died as a result of bronchial asthma with impact to his torso as a contributing factor, according to a report released by the Shelby County medical examiner's office Thursday morning. Payne, 15, died after

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AACR: Hay Fever, Asthma Tied to Lower Colorectal Cancer Death – Journal of the American Academy of Physician Assistants

AACR: Hay Fever, Asthma Tied to Lower Colorectal Cancer Death
Journal of the American Academy of Physician Assistants
(HealthDay News) – People with both hay fever and asthma have a modestly reduced risk of dying from colorectal cancer, according to a study presented at the American Association for Cancer Research's International Conference on Frontiers in Cancer
Study: Allergies May Protect from Colon CancerNewsmax Health

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AACR: Hay Fever, Asthma Tied to Lower Colorectal Cancer Death – Doctors Lounge


Globe and Mail

AACR: Hay Fever, Asthma Tied to Lower Colorectal Cancer Death
Doctors Lounge
People with both hay fever and asthma have a modestly reduced risk of dying from colorectal cancer, according to a study presented at the American Association for Cancer Research's International Conference on Frontiers in Cancer Prevention Research,
Do Hay Fever, Asthma, Lower Death Risk From Colorectal Cancer?EndoNurse
Can Allergies Thwart Fatal Colon Cancer?U.S. News & World Report

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