asthma; +25 new citations

25 new pubmed citations were retrieved for your search.
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asthma

These pubmed results were generated on 2011/02/08

PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950’s.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources.

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asthma; +27 new citations

27 new pubmed citations were retrieved for your search.
Click on the search hyperlink below to display the complete search results:

asthma

These pubmed results were generated on 2011/02/07

PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950’s.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources.

View full post on pubmed: asthma

Outpatient pulmonary rehabilitation – rehabilitation models and shortcomings in outpatient aftercare.

Outpatient pulmonary rehabilitation – rehabilitation models and shortcomings in outpatient aftercare.

GMS Health Technol Assess. 2010;6:Doc11

Authors: Korczak D, Huber B, Steinhauser G, Dietl M

BACKGROUND : The chronic obstructive pulmonary disease (COPD) and the bronchial asthma are widespread diseases. They need long-lasting and sustainable rehabilitation. OBJECTIVES : The goal of this HTA is to describe the present supply and the economic relevance of out-patient pulmonary rehabilitation in conjunction with its social aspects. A further target is to derivate options for actions in the health-care system and possible research necessities. METHODS : Relevant publications are identified by means of a structured search in 37 database accessed through the German Institute of Medical Documentation and Information (DIMDI). In addition a manual search of identified reference lists has been done. The present report includes German and English literature published from 2004 to 2009. The methodological quality was assessed by two independent researchers according to pre-defined quality criteria of evidence based medicine. RESULTS : Among 860 publications 31 medical studies, four economic studies and 13 ethical studies meet the inclusion criteria. The studies cover rehabilitation programmes in 19 countries. The majority of them has a high level of evidence (1A to 2C). The pulmonary rehabilitation programmes differ by the setting (in-patient, out-patient, in-home, community-based), by the length of intervention (from two weeks to 36 months), by the way and the frequency of intervention and by the duration of the follow-up treatment. Overall out-patient rehabilitation programmes achieve the same positive effects for COPD patients as in-patient programmes do. This is especially true for physical performance and health related quality of life. There are only a few studies dealing with asthma. Therefore, valid statements cannot be given. The results for cost-effectiveness are not distinct enough. DISCUSSION : Goals of pulmonary rehabilitation like prevention and adequate treatment of acute exacerbations, the minimisation of hospitalisation and the reduction of mortality are attained in out-patient as well as in in-patient pulmonary rehabilitation. Regarding the best frequency of training units per week or the duration and the content of a unit further research is needed. Final results for the ideal length of an in-patient rehabilitation are still missing. None of the studies deals with the analysis of the different treatment forms of a COPD which are frequently defined by an alteration of in-patient and out-patient treatments and participation in sports clubs or self-help groups. There are some other limitations of the studies. The results concerning self-management programmes are not distinct. (Self-) Selection leads to high drop-out rates. Many studies have only small sample sizes. Confounder and long-time effects are seldom researched, relevant economic evaluations do not exist The improvement of health related quality of life is primarily obtained by an improved disease management than by an improvement of a medical parameter. CONCLUSION : Out-patient pulmonary rehabilitation is as effective as in-patient pulmonary rehabilitation. But there is a critical shortage of out-patient pulmonary rehabilitation supply in Germany. Domains for further research are the evaluation of models for integrated care, the length, frequency and content of training programmes, psychiatric assessments and the cost-effectiveness of out-patient pulmonary rehabilitation.

PMID: 21289884 [PubMed – in process]

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Molecular expression and functional role of canonical transient receptor potential channels in airway smooth muscle cells.

Molecular expression and functional role of canonical transient receptor potential channels in airway smooth muscle cells.

Adv Exp Med Biol. 2011;704:731-47

Authors: Wang YX, Zheng YM

Multiple canonical or classic transient receptor potential (TRPC) molecules are expressed in animal and human airway smooth muscle cells (SMCs). TRPC3, but not TRPC1, is a major molecular component of native non-selective cation channels (NSCCs) to contribute to the resting [Ca(2+)](i) and muscarinic increase in [Ca(2+)](i) in freshly isolated airway SMCs. TRPC3-encoded NSCCs are significantly increased in expression and activity in airway SMCs from ovalbumin-sensitized/challenged “asthmatic” mice, whereas TRPC1-encoded channel activity, but not its expression, is largely augmented. The upregulated TRPC3- and TRPC1-encoded NSCC activity both mediate “asthmatic” membrane depolarization in airway SMCs. Supportively, tumor necrosis factor-? (TNF?), an important asthma mediator, increases TRPC3 expression, and TRPC3 gene silencing inhibits TNF?-mediated augmentation of acetylcholine-evoked increase in [Ca(2+)](i) in passaged airway SMCs. In contrast, TRPC6 gene silencing has no effect on 1-oleoyl-2-acetyl-sn-glycerol (OAG)-evoked increase in [Ca(2+)](i) in primary isolated cells. These findings provide compelling information indicating that TRPC3-encoded NSCCs are important for physiological and pathological cellular responses in airway SMCs. However, continual studies are necessary to further determine whether, which, and how TRPC-encoded channels are involved in cellular responses in normal and diseased (e.g., asthmatic) airway SMCs.

PMID: 21290324 [PubMed – in process]

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Risk factors for current wheezing and its phenotypes among elementary school children.

Risk factors for current wheezing and its phenotypes among elementary school children.

Pediatr Pulmonol. 2011 Feb;46(2):166-174

Authors: Civelek E, Cakir B, Orhan F, Yuksel H, Boz AB, Uner A, Sekerel BE

BACKGROUND: Accumulating evidence suggests, asthma includes many phenotypes with varying clinical and prognostic features. Epidemiological surveys documented a number of environmental risk factors for the development of asthma and interestingly these differ between and within countries, suggesting that the differences may be related with the different distribution of asthma phenotypes. This study aimed to investigate risk factors of current wheezing (CW) and different wheezing phenotypes in elementary school children. METHODS: Six thousand nine hundred sixty-three 9- to 11-year-old children of a previous multicenter survey where the methodology of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase-II was used were analyzed. Wheezing phenotypes were defined as wheezing with rhinitis (RW), wheezing with rhinoconjunctivitis (RCW), atopic wheezing (AW), non-atopic wheezing (NAW), and frequent wheezing (FW) (?4/year wheezing episodes). RESULTS: The prevalence of CW was 15.8% and among these, 22.4%, 67.3%, 45.9%, 20.5%, and 79.5% were classified as FW, RW, RCW, AW, and NAW, respectively. History of parental asthma/allergic rhinitis, coexistence of other allergic diseases, presence of mold and dampness in the house lived during the first year of life and maternal smoking in pregnancy were found to be risk factors for most phenotypes (odds ratio (OR) ranged from 1.43 to 3.56). Number of household in the last year (OR?=?1.14), prematurity (OR?=?2.08), and duration of breastfeeding (OR?=?1.02) per additional month were found to be risk factor for FW, AW, and RCW, respectively. CONCLUSION: Beside common risk factors for the development of asthma and its phenotypes, certain risk factors appeared to play a role in the development of phenotypic characteristics of asthma. These findings support our hypothesis that each phenotype has not only different clinical characteristics but also has different roots. Pediatr. Pulmonol. 2011; 46:166-174. © 2011 Wiley-Liss, Inc.

PMID: 21290615 [PubMed – as supplied by publisher]

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asthma; +17 new citations

17 new pubmed citations were retrieved for your search.
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asthma

These pubmed results were generated on 2011/02/03

PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950’s.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources.

View full post on pubmed: asthma

asthma; +34 new citations

34 new pubmed citations were retrieved for your search.
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asthma

These pubmed results were generated on 2011/02/02

PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950’s.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources.

View full post on pubmed: asthma

asthma; +21 new citations

21 new pubmed citations were retrieved for your search.
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asthma

These pubmed results were generated on 2011/01/22

PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950’s.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources.

View full post on pubmed: asthma

asthma; +110 new citations

110 new pubmed citations were retrieved for your search.
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asthma

These pubmed results were generated on 2011/01/21

PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950’s.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources.

View full post on pubmed: asthma

asthma; +16 new citations

16 new pubmed citations were retrieved for your search.
Click on the search hyperlink below to display the complete search results:

asthma

These pubmed results were generated on 2011/01/13

PubMed, a service of the National Library of Medicine, includes over 15 million
citations for biomedical articles back to the 1950’s.
These citations are from MEDLINE and additional life science journals.
PubMed includes links to many sites providing full text articles and other related resources.

View full post on pubmed: asthma