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Association of interleukin-18 and asthma.

Association of interleukin-18 and asthma.

Inflammation. 2016 Dec 02;

Authors: Xu MH, Yuan FL, Wang SJ, Xu HY, Li CW, Tong X

Abstract
Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity. IL-18 can act as a cofactor for Th2 cell development and IgE production and also plays an important role in the differentiation of Th1 cells. Recent work identified an IL-18 association with the pathogenesis of asthma, wherein increased IL-18 expression was found in the serum of patients. Furthermore, IL-18 polymorphisms with susceptibility to asthma were reported, suggesting that IL-18 may be therapeutically relevant to asthma. In this review, we discuss the role of IL-18 in the pathogenesis of asthma and its therapeutic potential based on current research.

PMID: 27913952 [PubMed – as supplied by publisher]

View full post on pubmed: asthma

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Association of Allergic Rhinitis and Sinusitis with Childhood Asthma.

Association of Allergic Rhinitis and Sinusitis with Childhood Asthma.

Indian Pediatr. 2016 Nov 5;:

Authors: Kumar S, Singh M, Das RR, Mathew JL, Saxena AK

Abstract
BACKGROUND: To study the point prevalence of allergic rhinitis and sinusitis in childhood asthma and to examine the relationships among them.
METHODS: In 250 children (age <13 y) with mild-to-moderte asthma, allergic rhinitis was diagnosed by clinical plus nasal eosinophilia criteria, and sinusitis was diagnosed clinically plus confirmation by computerized tomography scan.
RESULTS: The point prevalence of allergic rhinitis was 13.6%, and of sinusitis was 2%. On multivariate analysis, allergic rhinitis, sinusitis, and family history were significantly associated with asthma severity.
CONCLUSION: Allergic rhinitis is common in childhood, but sinusitis is rare.

PMID: 27889716 [PubMed – as supplied by publisher]

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Diagnosing Respiratory Disease in Children Using Cough Sounds

Conditions:   Pneumonia;   Bronchiolitis;   Asthma;   Croup;   Upper Respiratory Tract Infection;   Lower Respiratory Tract Infection
Intervention:   Other: Recording of Infants and Children’s Cough Sounds
Sponsors:   ResApp Health Limited;   Massachusetts General Hospital;   The Cleveland Clinic;   Texas Children’s Hospital
Not yet recruiting – verified November 2016

View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days

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Intranasal Curcumin Inhibits Pulmonary Fibrosis by Modulating Matrix Metalloproteinase-9 (MMP-9) in Ovalbumin-Induced Chronic Asthma.

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Intranasal Curcumin Inhibits Pulmonary Fibrosis by Modulating Matrix Metalloproteinase-9 (MMP-9) in Ovalbumin-Induced Chronic Asthma.

Inflammation. 2016 Nov 19;

Authors: Chauhan PS, Dash D, Singh R

Abstract
Pulmonary fibrosis is associated with irreversible, or partially reversible, airflow obstruction and ultimately unresponsiveness to asthma therapies such as corticosteroids. Intranasal curcumin, an anti-inflammatory molecule, has been found effective in allergic asthma. To study the effect of intranasal curcumin on airway remodeling and fibrosis in murine model of chronic asthma, BALB/c mice were sensitized to ovalbumin (OVA) and exposed to OVA aerosol (2%) from day 21 (after sensitization) for 5 weeks (twice/week). Curcumin (intranasal) was administered during the OVA aerosol challenge. Mice exposed to OVA developed inflammation dominated by eosinophils which lead to fibrosis and airway remodeling. Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with ?-smooth muscle actin (?-SMA), MMP-9, TIMP-1, and eotaxin expressions. These results suggest that intranasal curcumin regulates airway inflammation and remodeling in chronic asthma.

PMID: 27866296 [PubMed – as supplied by publisher]

View full post on pubmed: asthma