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Inhaler spacer devices to treat asthma in children
Nursing Times Drawing on literature searches and professional experience, this article discusses the treatment of asthma with pressurised metered dose inhalers (pMDIs). It demonstrates the need for pMDIs, and presents the health and cost benefits of using a pMDI … |
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Bronchial Hyperresponsiveness to Methacholine and AMP in Children With Atopic Asthma.
Allergy Asthma Immunol Res. 2012 Nov;4(6):341-5
Authors: Kang SH, Kim HY, Seo JH, Kwon JW, Jung YH, Song YH, Hong SJ
Abstract
PURPOSE: Bronchial hyperresponsiveness (BHR) is typically measured by bronchial challenge tests that employ direct stimulation by methacholine or indirect stimulation by adenosine 5′-monophosphate (AMP). Some studies have shown that the AMP challenge test provides a better reflection of airway inflammation, but few studies have examined the relationship between the AMP and methacholine challenge tests in children with asthma. We investigated the relationship between AMP and methacholine testing in children and adolescents with atopic asthma.
METHODS: The medical records of 130 children with atopic asthma (mean age, 10.63 years) were reviewed retrospectively. Methacholine and AMP test results, spirometry, skin prick test results, and blood tests for inflammatory markers (total IgE, eosinophils [total count, percent of white blood cells]) were analyzed.
RESULTS: The concentration of AMP that induces a 20% decline in forced expiratory volume in 1 second [FEV1] (PC20) of methacholine correlated with the PC20 of AMP (r(2)=0.189, P<0.001). No significant differences were observed in the levels of inflammatory markers (total eosinophil count, eosinophil percentage, and total IgE) between groups that were positive and negative for BHR to methacholine. However, significant differences in inflammatory markers were observed in groups that were positive and negative for BHR to AMP (log total eosinophil count, P=0.023; log total IgE, P=0.020, eosinophil percentage, P<0.001). In contrast, body mass index (BMI) was significantly different in the methacholine positive and negative groups (P=0.027), but not in the AMP positive and negative groups (P=0.62). The PC20 of methacholine correlated with FEV1, FEV1/forced vital capacity (FVC), and maximum mid-expiratory flow (MMEF) (P=0.001, 0.011, 0.001, respectively), and the PC20 of AMP correlated with FEV1, FEV1/FVC, and MMEF (P=0.008, 0.046, 0.001, respectively).
CONCLUSIONS: Our results suggest that the AMP and methacholine challenge test results correlated well with respect to determining BHR. The BHR to AMP more likely implicated airway inflammation in children with atopic asthma. In contrast, the BHR to methacholine was related to BMI.
PMID: 23115730 [PubMed – in process]
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Reference Intervals for Serum Immunoglobulins IgG, IgA, IgM and Complements C3 and C4 in Iranian Healthy Children.
Iran J Public Health. 2012;41(7):59-63
Authors: Kardar G, Oraei M, Shahsavani M, Namdar Z, Kazemisefat G, Haghi Ashtiani M, Shams S, Pourpak Z, Moin M
Abstract
BACKGROUND: Determination of reference ranges of each serum protein in normal population of each country is required for studies and clinical interpretation. The aim of this study was defining reference range values of immunoglobulins and complement components in Iranian healthy children.
METHODS: This study was conducted from June 2003 to June 2006 in Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences. Serum levels of IgG, IgM, IgA, C3 and C4 in 800 Iranian healthy children from newborn to 18 years of age in four population were measured by nephelometry. Kolmogrov-Smirnov tests and Pearson correlation tests were used for analysis.
RESULTS: Our results mainly agree with previous reports, except for some discrepancy that might be due to the ethnic and geographic variety. There was a significant difference between two sexes only with IgA in the group of 1-3 months old, which was higher in male group and IgM in groups of 3-5, 6-8 and 9-11 years old that were higher in female groups. Mean of other serum immunoglobulins and complements was not significantly different between male and female groups.
CONCLUSION: These results can be considered as a local reference for use in laboratories, clinical interpretations, and research for Iranian children.
PMID: 23113211 [PubMed – in process]
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Connect, Commit 2012: Coalition helps children control asthma
Shelby Star The Cleveland County Asthma Coalition provides education and activities to children who battle the condition. CCAC's goal at Connect, Commit to Change is to raise money to fund scholarships for children to attend its "No-Wheeze" asthma camp. |
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 Brisbane Times |
bright future for Aussie children
The Australian The report by the Australian Institute of Health and Welfare released today, A picture of Australia's children 2012, found asthma among children aged 0-15 had decreased from 13.5 per cent in 2001 to 9.9 per cent in 2007/08. Digital Pass $1 for first 28 … Report highlights child healthcare needs |
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 Toronto Star |
New guidelines help doctors diagnose heart failure in children
Toronto Star A child with shortness of breath, rapid heart rate and some coughing may be suffering not from asthma but from heart failure. That's according to new guidelines aimed at helping frontline doctors recognize pediatric heart failure that were issued … Children's heart failure may be overlooked in ER New guidelines help doctors spot potentially deadly heart failure in children New pediatric heart failure guidelines a first in Canada |
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bright future for Aussie children
Herald Sun The report by the Australian Institute of Health and Welfare released today, A picture of Australia's children 2012, found asthma among children aged 0-15 had decreased from 13.5 per cent in 2001 to 9.9 per cent in 2007/08. Digital Pass – $5 weekend … |
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Asthmatic children may suffer more from dirty hands – chicagotribune.com
Chicago Tribune NEW YORK (Reuters Health) – An arsenal of hand sanitizers, hygiene education and good old-fashioned soap failed to prevent asthma attacks among school children in one Alabama county. For children with asthma, the common cold is the top trigger of … |
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Keeping sick buildings from making children sick
Cincinnati.com “We were shocked when we saw the same management,” said Andrew Beck, a Children's pediatrician specializing in asthma analysis and treatment. He is the lead author of an article on the project that will be published in the November issue of Pediatrics. |
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Tonsil and adenoid removal reduces asthma symptoms in children
Medical Xpress Researchers from Children's Hospital and Research Center in Oakland, California, followed 105 children with asthma (7-21 years) referred for sleep study for suspected sleep apnea. Twenty-four patients with sleep apnea required T&A, of which 11 patients … |
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