LINX®, a Novel Treatment for Patients With Refractory Asthma Complicated by Gastroesophageal Reflux Disease – Medscape

LINX®, a Novel Treatment for Patients With Refractory Asthma Complicated by Gastroesophageal Reflux Disease
Medscape
Background: Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and …

View full post on asthma – Google News

Abietic acid attenuates allergic airway inflammation in a mouse allergic asthma model.

Abietic acid attenuates allergic airway inflammation in a mouse allergic asthma model.

Int Immunopharmacol. 2016 Jun 16;38:261-266

Authors: Gao Y, Zhaoyu L, Xiangming F, Chunyi L, Jiayu P, Lu S, Jitao C, Liangcai C, Jifang L

Abstract
Abietic acid (AA), one of the terpenoids isolated from Pimenta racemosa var. grissea, has been reported to have anti-inflammatory and immunomodulatory effects. However, the anti-allergic effects of AA remain unclear. The aim of this study was to investigate the anti-allergic effects of AA in an ovalbumin (OVA)-induced asthma murine model. The model of mouse asthma was established by induction of OVA. AA (10, 20, 40mg/kg) was administered by oral gavage 1h after the OVA treatment on days 21 to 23. At 24h after the last challenge, bronchoalveolar lavage fluid (BALF) and lung tissues were collected to assess pathological changes, cytokines production, and NF-?B expression. The results showed that AA attenuated lung histopathologic changes, inflammatory cells infiltration, and bronchial hyper-responsiveness. AA also inhibited OVA-induced the nitric oxide (NO), IL-4, IL-5, IL-13, and OVA-specific IgE production, as well as NF-?B activation. In conclusion, the current study demonstrated that AA exhibited protective effects against OVA-induced allergic asthma in mice and the possible mechanism was involved in inhibiting NF-?B activation.

PMID: 27318791 [PubMed – as supplied by publisher]

View full post on pubmed: asthma

How to manage asthma, which can be triggered by exercise, dogs, even cold air – Fredericksburg.com

How to manage asthma, which can be triggered by exercise, dogs, even cold air
Fredericksburg.com
At their worst, asthma attacks can mean a sudden trip to the emergency room. These can be scary episodes in their own right, but they also disrupt everyday life, interfering with sleep, school or work schedules. Preventing such attacks is a major goal

View full post on asthma – Google News

Bronchitis vs. asthma: Differences in symptoms, causes, and treatment options – Bel Marra Health


Bel Marra Health

Bronchitis vs. asthma: Differences in symptoms, causes, and treatment options
Bel Marra Health
An asthmatic attack will not trigger bronchitis, but a bout of bronchitis in an asthmatic patient can cause a flare-up of the asthma symptoms. In fact, this happens so often that many young medical students often ask the question, “can bronchitis lead

View full post on asthma – Google News