Breathe Well Live Well
Condition: Asthma
Interventions: Drug: Fluticasone furoate (FF) Dry Powder Inhaler; Drug: Fluticasone propionate (FP) Dry Powder Inhaler; Drug: Budesonide (BUD) Turbuhaler; Drug: Placebo (ELLIPTA or DISKUS)
Sponsor: GlaxoSmithKline
Not yet recruiting – verified December 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Polymorphic Variants 279R and 668Q Augment Activity of Matrix Metalloproteinase-9 in Breath Condensates of Children with Asthma.
Arch Immunol Ther Exp (Warsz). 2016 Jul 9;
Authors: Grzela K, Zagórska W, Krejner A, Litwiniuk M, Zawadzka-Krajewska A, Kulus M, Grzela T
Abstract
Matrix metalloproteinase (MMP)-9 is involved in pathophysiology of asthma, mainly asthma-associated airway remodeling. Exhaled breath condensates (EBC) of asthmatics contain increased amounts of MMP-9 with activity higher, than in healthy controls. The increased activity of MMP-9 may originate from its excessive production and activation, but may also result from variations in MMP-9 structure, which are determined by single nucleotide polymorphisms (SNPs). In this pilot study we aimed to assess the possible influence of two functional MMP-9 polymorphisms, Q279R and R668Q, on enzymatic activity of MMP-9, measured in EBC of asthmatic children. The concentration and activity of MMP-9 were analyzed in EBC of 20 children with allergic asthma using specific standard ELISA and novel immunoenzymatic activity assay. The SNPs of MMP-9 were assessed using real-time PCR-based genotyping test. We have found that MMP-9 concentration in breath condensates of children with stable asthma was slightly higher in ELISA, than in the activity assay. Moreover, these results and activity-to-amount ratio have revealed some relationship with a presence of specific 279R and/or 668Q MMP-9 gene variants. Our observation suggests that at least in some patients MMP-9 hyperactivity may result from genetic predisposition, determined by polymorphic variants of MMP-9 gene. Moreover, it supports previous reports postulating significance of MMP-9 in pathogenesis of asthma. However, this issue still requires further studies.
PMID: 27395373 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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Associations of Physical Activity and Sedentary Behavior with Atopic Disease in United States Children.
J Pediatr. 2016 May 4;
Authors: Strom MA, Silverberg JI
Abstract
OBJECTIVES: To determine if eczema, asthma, and hay fever are associated with vigorous physical activity, television/video game usage, and sports participation and if sleep disturbance modifies such associations.
STUDY DESIGN: Data were analyzed from 2 cross-sectional studies including 133?107 children age 6-17 years enrolled in the 2003-2004 and 2007-2008 National Survey of Children’s Health. Bivariate and multivariate survey logistic regression models were created to calculate the odds of atopic disease and atopic disease severity on vigorous physical activity, television/video game use, and sports participation.
RESULTS: In multivariate logistic regression models controlling for sociodemographic factors, lifetime history of asthma was associated with decreased odds of ?1 days of vigorous physical activity (aOR, 0.87; 95% CI, 0.77-0.99) and decreased odds of sports participation (0.91; 95% CI, 0.84-0.99). Atopic disease accompanied by sleep disturbance had significantly higher odds of screen time and lower odds of sports participation compared with children with either atopic disease or sleep disturbance alone. Severe eczema (aOR, 0.39; 95% CI, 0.19-0.78), asthma (aOR, 0.29; 95% CI, 0.14-0.61), and hay fever (aOR, 0.48; 95% CI, 0.24-0.97) were all associated with decreased odds of ?1 days of vigorous physical activity. Moderate (aOR, 0.76; 95% CI, 0.57-0.99) and severe eczema (aOR, 0.45; 95% CI, 0.28-0.73), severe asthma (aOR, 0.47; 95% CI, 0.25-0.89), and hay fever (aOR, 0.53; 95% CI, 0.36-0.61) were associated with decreased odds of sports participation in the past year.
CONCLUSIONS: Children with severe atopic disease, accompanied by sleep disturbance, have higher risk of sedentary behaviors.
PMID: 27156181 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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Higher levels of physical activity associated with poorer asthma control in …
Healio Patients with asthma had higher levels of activity compared with patients in a control group, with females who had poor asthma control displaying higher levels of activity compared with males in the study, according to recent research published in … |
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Medscape |
High Physical Activity Tied to Poor Asthma Control in Females
Medscape In a study of 526 adolescents and young adults who were asked about how much they exercised, researchers found that compared with moderate physical activity, high physical activity levels were linked with poorer asthma control in females, but not males. High levels of physical activity may worsen asthma control in young females A picture from your cell phone could lead to treatment for acne |
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KTAL |
High physical activity levels associated with poorer asthma control in females
News-Medical.net Among 526 adolescents and young adults who were asked about their exercise habits, those with asthma tended to report more physical activity than those without asthma. Compared with moderate physical activity, high physical activity levels were linked … A picture from your cell phone could lead to treatment for acne |
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High levels of physical activity may worsen asthma control in young females
EurekAlert (press release) Among 526 adolescents and young adults who were asked about their exercise habits, those with asthma tended to report more physical activity than those without asthma. Compared with moderate physical activity, high physical activity levels were linked … |
View full post on asthma – Google News
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Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-?, IL-?, IL-6 and IL-17A.
Immunobiology. 2015 Sep 8;
Authors: Charrad R, Berraïes A, Hamdi B, Ammar J, Hamzaoui K, Hamzaoui A
Abstract
BACKGROUND: The aim of this study was to assess interleukin (IL)-37 production in asthmatic children in serum and induced sputum and to look to the impact of IL-37 on pro-inflammatory cytokines production (TNF-?, IL-6, IL-1? and IL-17).
METHODS: Forty children with well-controlled asthma (20 moderate and 20 mild asthmatics) were studied. IL-37 was measured by ELISA in serum and induced sputum (IS) samples, and compared with 22 age- and sex-matched healthy controls. Real-time quantitative PCR was used to determine IL-37 mRNA expression in induced sputum cells. Induced sputum mononuclear cells from 10 moderate asthmatics and 10 healthy controls were stimulated either with lipopolysaccharides (LPS) or LPS plus recombinant IL-37 (rIL-37) comparing pro-inflammatory cytokines production. TNF-?, IL-1?, IL-6 and IL-17 were measured by RT-PCR and ELISA.
FINDINGS: The expression of IL-37 mRNA in asthmatic patients was significantly lower than that observed in healthy controls (P=0.0001). IL37 mRNA expression depended on asthma severity. Serum and IS IL-37 levels were significantly lower in asthma patients compared to healthy controls. LPS-stimulated sputum cells from asthma patients produced higher levels of IL-1?, IL-6, and TNF-? than those from HC. Adding rIL-37 suppressed TNF-?, IL-1? and IL-6 production in IS cells. In the same way, stimulating IS CD4(+) T cells in the presence of rIL-37 inhibited IL-17 production both in asthma patients and HC. IL-37 effect on IL-17 was more pronounced in patients than controls.
INTERPRETATION: The decrease in IL-37 level observed in IS was found to correlate with disease severity. The increased pro-inflammatory cytokines production from asthma IS cells was abrogated by the addition of rIL-37. IL-37 could be an important cytokine in the control of asthma by suppressing the production of inflammatory cytokines.
PMID: 26454413 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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Asthma, obesity impact physical activity in adolescents
Healio The analysis included 545 adolescents, 11% of whom had lifetime asthma. All adolescents with asthma participated in less physical activity and girls participated less often than boys. Sex correlated with sedentary behavior as well (P < .001). Boys with … |
View full post on asthma – Google News
Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: Aclidinium/Formoterol; Drug: Placebo
Sponsors: AstraZeneca; Menarini (Co-Funder)
Not yet recruiting – verified April 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days