Breathe Well Live Well
Condition: Inadequately Controlled Asthma
Intervention: Biological: Tralokinumab open-label
Sponsor: AstraZeneca
Not yet recruiting – verified September 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Condition: Asthma
Intervention: Behavioral: CampAir
Sponsors: 3-C Institute for Social Development; Columbia University; New York University
Recruiting – verified June 2016
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Bel Marra Health |
Severe asthma linked to insomnia, sleep duration, and sleep hygiene in adolescents
Bel Marra Health severe-asthma-linked-to-insomnia-sleep-duration-and- Severe asthma is linked to insomnia, sleep duration, and sleep hygiene in adolescents. The findings were published in The Journal of Allergy and Clinical Immunology: In Practice. The researchers … |
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SPIRIVA® RESPIMAT® Now Available in the U.S. for Maintenance Treatment of Asthma in Adults and Adolescents
Business Wire (press release) INGELHEIM, Germany–(BUSINESS WIRE)–Boehringer Ingelheim today announced that SPIRIVA® RESPIMAT® is now available for the treatment of asthma by prescription in U.S. pharmacies. The U.S. Food and Drug Administration (FDA) approved a … |
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SPIRIVA ® RESPIMAT ® Now Available in the US for Maintenance Treatment of Asthma in Adults and Adolescents
Business Wire (press release) INGELHEIM, Germany–(BUSINESS WIRE)–Boehringer Ingelheim today announced that SPIRIVA® RESPIMAT® is now available for the treatment of asthma by prescription in U.S. pharmacies. The U.S. Food and Drug Administration (FDA) approved a … SPIRIVA RESPIMAT Now Available in the US for Maintenance Treatment of Asthma in Adults and Adolescents |
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SPIRIVA RESPIMAT Now Available in the U.S. for Maintenance Treatment of Asthma in Adults and Adolescents
PR Newswire (press release) RIDGEFIELD, Conn., Feb. 3, 2016 /PRNewswire/ — Boehringer Ingelheim Pharmaceuticals, Inc. today announced that SPIRIVA RESPIMAT is now available by prescription for the treatment of asthma in U.S. pharmacies. The U.S. Food and Drug … |
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Leukotriene-Receptor Antagonists Versus Placebo in the Treatment of Asthma in Adults and Adolescents: A Systematic Review and Meta-Analysis.
Ann Intern Med. 2015 Sep 22;
Authors: Miligkos M, Bannuru RR, Alkofide H, Kher SR, Schmid CH, Balk EM
Abstract
Background: Leukotriene-receptor antagonists (LTRAs) are recommended as an alternative treatment in patients with mild asthma, but their effect compared with placebo is unclear.
Purpose: To determine the benefits and harms of LTRAs as monotherapy or in combination with inhaled corticosteroids compared with placebo in adults and adolescents with asthma.
Data Sources: MEDLINE and the Cochrane Central Register of Controlled Trials from inception through June 2015.
Study Selection: Peer-reviewed, English-language, randomized, controlled trials in patients with asthma that reported the effect of LTRAs versus placebo on measures of asthma control.
Data Extraction: Three researchers extracted data on study population, interventions, outcome measures, and adverse events. One researcher assessed risk of bias.
Data Synthesis: Of the 2008 abstracts that were screened, 50 trials met eligibility criteria. Random-effects meta-analyses of 6 trials of LTRA monotherapy showed that LTRAs reduced the risk for an exacerbation (summary risk ratio [RR], 0.60 [95% CI, 0.44 to 0.81]). In 4 trials of LTRAs as add-on therapy to inhaled corticosteroids, the summary RR for exacerbation was 0.80 (CI, 0.60 to 1.07). Leukotriene-receptor antagonists either as monotherapy or add-on therapy to inhaled corticosteroids increased FEV1, whereas FEV1 percentage of predicted values was only improved in trials of LTRA monotherapy. Adverse event rates were similar in the intervention and comparator groups.
Limitation: Variation in definitions and reporting of outcomes, high risk of bias in some studies, heterogeneity of findings, possible selective outcome reporting bias, and inability to assess the effect of asthma severity on summary estimates.
Conclusion: Leukotriene-receptor antagonists as monotherapy improved asthma control compared with placebo, but which patients are most likely to respond to treatment with LTRAs remains unclear.
Primary Funding Source: National Institutes of Health.
PMID: 26390230 [PubMed – as supplied by publisher]
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FDA approves Spiriva Respimat for asthma in adults, adolescents
Healio “The [FDA] approval of Spiriva Respimat in asthma establishes a new class of inhaled asthma therapy and provides an efficacious, new option for patients,” William Mezzanotte, MD, MPH, said in the release. “There is extensive clinical evidence … |
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Related Articles |
Atopic dermatitis is associated with Caesarean sections in Korean adolescents but asthma is not.
Acta Paediatr. 2015 Sep 12;
Authors: Yu M, Han K, Kim DH, Nam GE
Abstract
AIM: Studies on the associations between mode of delivery and allergic diseases have produced different results and research has rarely been conducted in Asian countries such as South Korea. This study assessed the relationship between mode of delivery and atopic dermatitis and asthma in Korean adolescents.
METHODS: Data collected from the Korea National Health and Nutrition Examination Survey between 2010 and 2011 were used. We included 1,302 adolescents aged from 12-18 years and multivariable logistic regression analysis was performed.
RESULTS: The odds ratio (OR) of having atopic dermatitis was 1.50, with a 95% confidence interval (95% CI) of 1.01-2.22, after adjusting for age and sex. The association remained significant after further adjustments for body mass index, breastfeeding and serum 25-hydroxyvitamin D level (OR = 1.61, 95% CI = 1.05-2.47) and when fat intake was added to those variables (OR = 1.80, 95% CI = 1.14-2.85). However, asthma was not associated with mode of delivery in any of the models.
CONCLUSIONS: Atopic dermatitis in adolescents was associated with Caesarean delivery, which is common in South Korea. The findings suggest that the frequency of this practice should be reconsidered and that further research with longitudinal evaluation of relevant mechanisms is needed. This article is protected by copyright. All rights reserved.
PMID: 26363368 [PubMed – as supplied by publisher]
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Asthma, obesity impact physical activity in adolescents
Healio The analysis included 545 adolescents, 11% of whom had lifetime asthma. All adolescents with asthma participated in less physical activity and girls participated less often than boys. Sex correlated with sedentary behavior as well (P < .001). Boys with … |
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