European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): a Real-Life Clinical Assessment.

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European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): a Real-Life Clinical Assessment.

Allergy. 2016 Oct 8;:

Authors: Calderón MA, Vidal C, Rodríguez Del Río P, Just J, Pfaar O, Tabar AI, Sánchez-Machín I, Bubel P, Borja J, Eberle P, Reiber R, Bouvier M, Lepelliez A, Klimek L, Demoly P, EASSI Doctors’ Group

Abstract
BACKGROUND: Outside clinical trials, data on systemic reactions (SRs) due to allergen immunotherapy (AIT) are scarce.
METHODS: A prospective, longitudinal, web-based survey of “real-life” respiratory allergen immunotherapy (AIT) clinical practice was conducted in France, Germany and Spain. SRs were recorded and coded according to the Medical Dictionary for Regulatory Activities (MedDRA) and risk factors associated with SRs were identified.
RESULTS: A total of 4,316 patients (corresponding to 4,363 ongoing courses of AIT) were included. 109 SRs were recorded, and 90 patients (2.1%) presented at least one SR. Most of the SRs occurred in subcutaneous allergen immunotherapy (SCIT) (89%, n=97). The most frequently reported symptoms were urticaria, rhinitis, dyspnoea and cough. Respiratory symptoms appeared before skin symptoms. Most SRs occurred during the up-dosing phase (75.8%) and were mild in severity (71.6%). Intramuscular adrenaline was administered in 17 SRs but only 65% of these were subsequently classified as anaphylaxis. Independent risk factors for SRs during SCIT were: the use of natural extracts (odds ratio (OR) [95% confidence interval (CI)]=2.74 [1.61-4.87]; p=0.001), the absence of symptomatic allergy medications (1.707 [1.008-2.892], p=0.047), asthma diagnosis (1.74 [1.05-2.88], p=0.03), sensitization to animal dander (1.93 [1.21-3.09]; p=0.006) or pollen (1.16 [1.03-1.30]; p=0.012), and cluster regimens (vs. rush) (4.18 [1.21-14.37]; p=0.023). A previous episode of anaphylaxis increased the risk for anaphylaxis in SCIT (OR [95%CI]=17.35 [1.91-157.28]; p=0.01).
CONCLUSION: AIT for respiratory allergy is safe, with a low number of SRs observed in real-life clinical practice. A personalized analysis of risk factors could be used to minimize SRs. This article is protected by copyright. All rights reserved.

PMID: 27718250 [PubMed – as supplied by publisher]

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Adverse Childhood Experiences and Adult Health Outcomes Among Veteran and Non-Veteran Women.

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Adverse Childhood Experiences and Adult Health Outcomes Among Veteran and Non-Veteran Women.

J Womens Health (Larchmt). 2015 Sep;24(9):723-9

Authors: McCauley HL, Blosnich JR, Dichter ME

Abstract
BACKGROUND: Women veterans represent a vulnerable population with unique health needs and disparities in access to care. One constellation of exposures related to subsequent poor health includes adverse childhood experiences (ACEs; e.g., physical and sexual child abuse), though research on impacts of ACEs among women veterans is limited.
METHODS: Data were drawn from the 2010 Behavioral Risk Factor Surveillance System for the 11 states that included the ACE module (n=36,485). Weighted chi-squared tests and multivariable logistic regression were used to assess the prevalence of ACEs among women veterans compared with women non-veterans and differences in the following outcomes, controlling for ACEs: social support, inadequate sleep, life satisfaction, mental distress, smoking, heavy alcohol use, obesity, diabetes, cardiovascular disease symptoms, asthma, and disability.
RESULTS: Women veterans (1.6% of the total sample) reported a higher prevalence of 7 out of 11 childhood adversities and higher mean ACE score than women non-veterans. Women veterans were more likely to be current smokers and report a disability, associations which were attenuated when controlling for ACE.
CONCLUSIONS: Despite women veterans’ higher prevalence of ACE, their health outcomes did not differ substantially from non-veterans. Further research is needed to understand the intersections of traumatic experiences and sources of resilience over the lifecourse among women veterans.

PMID: 26390379 [PubMed – in process]

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Association Between Adverse Childhood Experiences and Pediatric Asthma … – Lung Disease News


Lung Disease News

Association Between Adverse Childhood Experiences and Pediatric Asthma
Lung Disease News
Results from a recent study conducted by a research team at the Hasbro Children's Hospital revealed an association between adverse childhood experiences and pediatric asthma. According to the study recently published in the Annals of Allergy, Asthma …
Children exposed to adverse childhood experience more likely to develop asthmaNews-Medical.net
Gene may play part in how kids respond to asthma medsWSFA

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Children exposed to adverse childhood experience more likely to develop asthma – News-Medical.net

Children exposed to adverse childhood experience more likely to develop asthma
News-Medical.net
Robyn Wing, M.D., an emergency medicine physician at Hasbro Children's Hospital, recently led a study that found children who were exposed to an adverse childhood experience (ACE) were 28 percent more likely to develop asthma. The rate of asthma …
Association Between Adverse Childhood Experiences and Pediatric Asthma Lung Disease News

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Adverse Childhood Experiences Make Children More Susceptible to Asthma – Lung Disease News


Lung Disease News

Adverse Childhood Experiences Make Children More Susceptible to Asthma
Lung Disease News
Several studies have suggested that psychosocial factors may play a role in pediatric asthma. In this study, researchers analyzed the possible relationship between parent-reported diagnosis of lifetime asthma in children and single or cumulative
Childhood Trauma May Raise Odds of AsthmaHealthDay

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Adverse childhood experiences may increase the risk of asthma, study finds – Medical News Today


Medical News Today

Adverse childhood experiences may increase the risk of asthma, study finds
Medical News Today
Being exposed to adverse experiences in childhood – such as witnessing domestic violence or drug abuse – could significantly increase the risk of developing asthma. This is the finding of a new study published in the Annals of Allergy, Asthma and …
Witnessing drug problems or domestic violence causes greater asthma incidenceMedical Xpress
More pollen, more problems for allergy sufferersNapa Valley Register
"Intense" Allergy Season Expected Following Cold WinterNBC4 Washington

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