Breathe Well Live Well
|
Virus Patterns Where Kids Live May Affect Asthma Risk
U.S. News & World Report WEDNESDAY, Sept. 26 (HealthDay News) — Infants in urban areas have different patterns of viral respiratory illness than those in the suburbs, which may explain why inner-city children are more likely to develop asthma, a new study suggests. The … Inner city infants have different patterns of viral respiratory illness than … |
View full post on asthma – Google News
 TopNews Arab Emirates |
Balance Could Affect Asthma Symptoms
RedOrbit Asthma patients could be at a higher risk of worsening symptoms due to problems with their balance, according to new research. The study will be presented today (2 September 2012) at the European Respiratory Society's Annual Congress in Vienna. Asthma symptoms aggravated by problems with balance Canberra This Week Sees National Asthma Awareness Campaign Asthma campaign targets schools |
View full post on asthma – Google News
 World First Travel Insurance |
How Will the London Smog Affect Olympians?
Medical Daily According to Dr. William Silvers, a member of the American Academy of Allergy, Asthma and Immunology's Sports Medicine Committee, the London smog runs the risk of inflicting exercise-induced bronchoconstriction. By Nikki Tucker | July 26, 2012 … Asthma charity encourages exercise London smog may be tough on Olympians |
View full post on asthma – Google News
|
London Pollution Could Affect Olympic Athletes' Performance
WIBW Demanding workouts in the polluted air could spell trouble particularly for those athletes that already have conditions such as asthma or exercise-induced bronchoconstriction (EIB), a narrowing of the airways that makes it hard to move air out of the … |
View full post on asthma – Google News
|
London pollution could affect Olympic athletes' performance
CNN (blog) Demanding workouts in the polluted air could spell trouble particularly for those athletes that already have conditions such as asthma or exercise-induced bronchoconstriction (EIB), a narrowing of the airways that makes it hard to move air out of the … Will London air sicken Olympic athletes? |
View full post on asthma – Google News
|
Obesity, exposure to pollutants affect asthma control
Medical Xpress (Phys.org) — Older adults who are obese or exposed to traffic pollutants are more likely to have poorly controlled asthma, according to University of Cincinnati (UC) researchers. Data from a study led by allergist Tolly Epstein, MD, … |
View full post on asthma – Google News
|
Obesity, Exposure to Pollutants Affect Asthma Control
HealthCanal.com CINCINNATI—Older adults who are obese or exposed to traffic pollutants are more likely to have poorly controlled asthma, according to University of Cincinnati (UC) researchers. Data from a study led by allergist Tolly Epstein, MD, assistant professor … |
View full post on asthma – Google News
|
Alternative Medicine Doesn't Affect Asthma Care in Children
Doctors Lounge Complementary and alternative medicine is not associated with adherence to pediatric asthma treatment, according to a study published online April 9 in Pediatrics. TUESDAY, April 10 (HealthDay News) — Complementary and alternative medicine (CAM) is … |
View full post on asthma – Google News
|
Don't let asthma affect quality of life
Wicklow People THE STATISTICS for asthma levels in Ireland are startling with more than one person a week dying from the condition that affects the small tubes that carry air in and out of the lungs. We actually have the fourth highest prevalence of asthma in the … |
View full post on asthma – Google News
Multiple Polymorphisms Affect Expression and Function of the Neuropeptide S Receptor (NPSR1).
PLoS One. 2011;6(12):e29523
Authors: Anedda F, Zucchelli M, Schepis D, Hellquist A, Corrado L, D’Alfonso S, Achour A, McInerney G, Bertorello A, Lördal M, Befrits R, Björk J, Bresso F, Törkvist L, Halfvarson J, Kere J, D’Amato M
Abstract
BACKGROUND: neuropeptide S (NPS) and its receptor NPSR1 act along the hypothalamic-pituitary-adrenal axis to modulate anxiety, fear responses, nociception and inflammation. The importance of the NPS-NPSR1 signaling pathway is highlighted by the observation that, in humans, NPSR1 polymorphism associates with asthma, inflammatory bowel disease, rheumatoid arthritis, panic disorders, and intermediate phenotypes of functional gastrointestinal disorders. Because of the genetic complexity at the NPSR1 locus, however, true causative variations remain to be identified, together with their specific effects on receptor expression or function. To gain insight into the mechanisms leading to NPSR1 disease-predisposing effects, we performed a thorough functional characterization of all NPSR1 promoter and coding SNPs commonly occurring in Caucasians (minor allele frequency >0.02).
PRINCIPAL FINDINGS: we identified one promoter SNP (rs2530547 [-103]) that significantly affects luciferase expression in gene reporter assays and NPSR1 mRNA levels in human leukocytes. We also detected quantitative differences in NPS-induced genome-wide transcriptional profiles and CRE-dependent luciferase activities associated with three NPSR1 non-synonymous SNPs (rs324981 [Ile107Asn], rs34705969 [Cys197Phe], rs727162 [Arg241Ser]), with a coding variant exhibiting a loss-of-function phenotype (197Phe). Potential mechanistic explanations were sought with molecular modelling and bioinformatics, and a pilot study of 2230 IBD cases and controls provided initial support to the hypothesis that different cis-combinations of these functional SNPs variably affect disease risk.
SIGNIFICANCE: these findings represent a first step to decipher NPSR1 locus complexity and its impact on several human conditions NPS antagonists have been recently described, and our results are of potential pharmacogenetic relevance.
PMID: 22216302 [PubMed – in process]
View full post on pubmed: asthma