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Frequent Bronchoconstriction Tied to Airway Remodeling
Doctors Lounge Experimentally induced bronchoconstriction may promote airway remodeling in patients with asthma, according to a study published in the May 26 issue of the New England Journal of Medicine. THURSDAY, May 26 (HealthDay News) — Experimentally induced … |
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Altered expression of microRNA in the airway wall in chronic asthma: miR-126 …
7thSpace Interactive (press release) In a mouse model, we have previously shown that miRNAs are potentially important therapeutic targets in allergic asthma, because inhibition of miR-126, one of a small subset of miRNAs upregulated in the airway wall, effectively suppressed Th2-driven … |
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Increased apoptosis of CD4 and CD8 T lymphocytes in the airways of horses with recurrent airway obstruction.
Vet Res Commun. 2011 May 19;
Authors: Moran G, Buechner-Maxwell VA, Folch H, Henriquez C, Galecio JS, Perez B, Carrasco C, Barria M
Recurrent airway obstruction (RAO, also known as equine heaves) is an inflammatory condition similar to human asthma caused by exposure of susceptible horses to poorly ventilated stable environments. The disease is characterized by neutrophilic airway inflammation, mucus hypersecretion and reversible bronchoconstriction. This inflammatory process is mediated by several factors, including antibodies, cytokines, resident cells of the airway and inflammatory cellular components that arrive in the respiratory tract. An increasing body of evidence has lent support to the concept that a dysregulation of T cell apoptosis may play a central role in the development of airway inflammation and the associated asthma. Therefore, the aim of this study was to investigate early and late apoptosis of CD4 and CD8 T cell subpopulations obtained from the airways of acute RAO-positive animals after exposure to hay/straw. The percentages of CD4 and CD8 T cells and their associated frequencies of apoptosis were quantified using flow cytometry. Hay/straw exposure induced clinical airway obstruction, airway neutrophilia and increased airway mucus production in RAO-positive horses. In addition, allergen exposure increased the percentage of CD4 T cells in RAO-positive horses as well as the frequency of early and late apoptosis in both CD4 and CD8 lymphocyte subpopulations. These results suggest that the higher frequency of lymphocyte apoptosis may play a role in disease progression of horses afflicted with RAO and may partially explain the characteristic remission of this pathological condition once the allergen source is removed. However, further studies are needed to clarify the role of T cell apoptosis in RAO-affected horses.
PMID: 21594641 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Grape Seed Proanthocyanidin Extract Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma by Downregulating Inducible Nitric Oxide Synthase.
Planta Med. 2011 Mar 30;
Authors: Zhou DY, Du Q, Li RR, Huang M, Zhang Q, Wei GZ
Allergic asthma is characterized by hyperresponsiveness and inflammation of the airway with increased expression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide (NO). Grape seed proanthocyanidin extract (GSPE) has been proved to have antioxidant, antitumor, anti-inflammatory, and other pharmacological effects. The purpose of this study was to examine the role of GSPE on airway inflammation and hyperresponsiveness in a mouse model of allergic asthma. BALB/c mice, sensitized and challenged with ovalbumin (OVA), were intraperitoneally injected with GSPE. Administration of GSPE remarkably suppressed airway resistance and reduced the total inflammatory cell and eosinophil counts in BALF. Treatment with GSPE significantly enhanced the interferon (IFN)- ? level and decreased interleukin (IL)-4 and IL-13 levels in BALF and total IgE levels in serum. GSPE also attenuated allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells in the airway. The elevated iNOS expression observed in the OVA mice was significantly inhibited by GSPE. In conclusion, GSPE decreases the progression of airway inflammation and hyperresponsiveness by downregulating the iNOS expression, promising to have a potential in the treatment of allergic asthma.
PMID: 21452107 [PubMed – as supplied by publisher]
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Protein linked to allergic response causes airway changes in asthmatics
Sify A study conducted by researchers at Duke University has found that changes that occur in the airways of asthma patients are in part caused by the naturally occurring protein interleukin-13 (IL-13) which stimulates invasion of airway cells called … Study finds that protein IL-13 stimulates fibroblast cells to invade the … |
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Study finds IL-13 stimulates airway fibroblast invasion in asthma patients
News-Medical.net Changes that occur in the airways of asthma patients are in part caused by the naturally occurring protein interleukin-13 (IL-13) which stimulates invasion of airway cells called fibroblasts, according to a study conducted by researchers at Duke … |
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Protein associated with allergic response causes airway changes in asthma patients
EurekAlert (press release) Changes that occur in the airways of asthma patients are in part caused by the naturally occurring protein interleukin-13 (IL-13) which stimulates invasion of airway cells called fibroblasts, according to a study conducted by researchers at Duke … |
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 UCSF Today |
Asthma tied to bacterial communities in the airway
EurekAlert (press release) Asthma may have a surprising relationship with the composition of the species of bacteria that inhabit bronchial airways, a finding that could suggest new treatment or even potential cures for the common inflammatory disease, according to a new … New study: Asthma may have relationship with airway microbiota composition |
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Asthma tied to bacterial communities in the airway
Eureka! Science News Asthma may have a surprising relationship with the composition of the species of bacteria that inhabit bronchial airways, a finding that could suggest new treatment or even potential cures for the common inflammatory disease, according to a new … |
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Asthma linked to bacterial communities in the airway
Daily News & Analysis A new UCSF-led study has found that asthma may have a surprising relationship with the composition of the species of bacteria that inhabit bronchial airways. This finding could suggest new treatment or even potential cures for the common inflammatory … |
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