Breathe Well Live Well
Condition: Asthma
Intervention: Biological: Segmental airway allergen challenge
Sponsors: University of California, San Francisco; National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting – verified August 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Conditions: Allergic Asthma; Allergic Rhinitis
Intervention:
Sponsor: Lithuanian University of Health Sciences
Recruiting – verified August 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Vitamin D supplementation improved airway function in patients with asthma
Healio Patients with asthma who were treated with vitamin D and asthma controllers had significantly improved airway function after 24 weeks compared with patients treated with asthma controllers alone, according to recent study results. Researchers studied … |
View full post on asthma – Google News
Fars News Agency |
Perceived harmful odor increased airway inflammation in patients with asthma
Healio Jaén and Pamela Dalton, PhD, a cognitive psychologist at Monell, studied 17 patients with asthma. Eleven were classified as having mild asthma (FEV1 greater than 80%), and six had severe asthma (FEV1 lower than 60%). All patients were exposed to 15 … Asthma: What You Think You Smell Matters |
View full post on asthma – Google News
Medical News Today |
Asthma: just believing an odor is harmful 'could trigger airway inflammation'
Medical News Today For many individuals with asthma, exposure to some odors – such as perfume – can increase inflammation of the airways. But according to a new study by researchers from the Monell Chemical Senses Center in Philadelphia, PA, just believing an odor will … New research reveals how expectations about odors can influence symptoms of … Asthmatic? Stop worrying about smells Worrying about smells can make asthma worse |
View full post on asthma – Google News
Condition: Asthma
Interventions: Drug: lebrikizumnab; Other: placebo
Sponsor: Hoffmann-La Roche
Not yet recruiting – verified March 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Conditions: Asthma; COPD
Intervention:
Sponsor: Medical University of Warsaw
Recruiting – verified February 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: ASTHMA
Intervention: Other: Exhaled breath temperature
Sponsor: Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau
Recruiting – verified February 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
| Related Articles |
Emergence of airway smooth muscle mechanical behaviour through dynamic reorganisation of contractile units and force transmission pathways.
J Appl Physiol (1985). 2014 Jan 30;
Authors: Brook BS
Abstract
Airway hyper-responsiveness (AHR) in asthma remains poorly understood despite significant research effort to elucidate relevant underlying mechanisms. In particular, a significant body of experimental work has focussed on the effect of tidal fluctuations on airway smooth muscle (ASM) cells, tissues, lung slices and whole airways in order to understand the bronchodilating effect of tidal breathing and deep inspirations. These studies have motivated conceptual models that involve dynamic reorganisation of both cytoskeletal components as well contractile machinery. In this paper, a biophysical model of the whole ASM cell is presented which combines (i) crossbridge cycling between actin and myosin, (ii) actin-myosin disconnectivity, under imposed length changes, to allow dynamic reconfiguration of “force transmission pathways” and (iii) dynamic parallel-to-serial transitions of contractile units within these pathways, that occur through a length fluctuation. Results of this theoretical model suggest that behaviour characteristic of experimentally observed force-length loops of maximally activated ASM strips can be explained by interactions between the three mechanisms. Crucially, both sustained disconnectivity and parallel-to-serial transitions are necessary to explain the nature of hysteresis and strain-stiffening observed experimentally. The results provide strong evidence that dynamic rearrangement of contractile machinery is a likely mechanism underlying many of the phenomena observed at timescales associated with tidal breathing. This theoretical cell-level model captures many of the salient features of mechanical behaviour observed experimentally and should provide a useful starting block for a bottom-up approach to understanding tissue-level mechanical behaviour.
PMID: 24481961 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Chronic Rhino-Sinusitis and Asthma: Concept of Unified Airway Disease (UAD) and its Impact in Otolaryngology.
Indian J Otolaryngol Head Neck Surg. 2013 Aug;65(Suppl 2):338-42
Authors: Meena RS, Meena D, Aseri Y, Singh BK, Verma PC
Abstract
The aim of our study is to understand the concept of unified airway disease, to know the advantage of this concept in the diagnosis and treatment of allergic rhinitis, chronic rhino-sinusitis and asthma, to know its impact on practice of otolaryngologists, to motivate the otorhinolaryngologist to apply this concept in diagnosis and treatment. This article is based on our experience on (20 cases) chronic rhino-sinusitis and asthma, and observations and results from various literatures. Implement of the concept of unified airway disease and ability to translate its principles into successful diagnostic and treatment strategies can enhance the practice of otolaryngology. The end result is the potential for improved patient care. In our study 80% cases have reduced frequency of symptoms and all (100%) cases having improved night time symptoms thus the use of short-acting beta2 agonist to control the asthma symptoms decreases.
PMID: 24427673 [PubMed]
View full post on pubmed: asthma