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Asthma infection risk 'goes beyond the airways'
medwireNews medwireNews: Researchers from the USA have found that asthma may be associated with an increased risk for infections outside of the respiratory tract. Multiple previous studies have shown that patients with asthma are more likely to experience … |
View full post on asthma – Google News
Condition: Asthma
Intervention: Drug: Qvar® (beclometasone dipropionate HFA)
Sponsors: University of Dundee; University of Dundee; Teva Pharmaceuticals USA
Not yet recruiting – verified July 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Asthma
Interventions: Drug: Formoterol; Drug: Salmeterol
Sponsors: University of Dundee; University of Dundee; Chiesi Farmaceutici S.p.A.
Not yet recruiting – verified July 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
 KARE |
New asthma treatment opens airways with heat
KARE Greg Morgan had the bronchial thermoplasty procedure last October. His severe asthma had him on his couch for a whole month last summer. He says he used his inhaler and nebulizer from ten to 26 times a day. Within a two-year period, he was hospitalized … |
View full post on asthma – Google News
Diffusion lung capacity of carbon monoxide: A novel marker of airways remodeling in asthmatic children?
Allergy Rhinol (Providence). 2012;3(2):e66-73
Authors: Piacentini GL, Tezza G, Cattazzo E, Kantar A, Ragazzo V, Boner AL, Peroni DG
Abstract
Asthma is universally considered a chronic inflammatory disorder of the airways. Several noninvasive markers, such as exhaled nitric oxide (FeNO) and exhaled breath temperature (PletM), have been proposed to evaluate the degree of airway inflammation and remodeling in asthmatic children. The aim of this study was to evaluate the relationship between diffusion lung capacity of carbon monoxide (DLCO) and these inflammatory markers in asthmatic children. We compared data of FeNO, PletM, and DLCO collected in 35 asthmatic children at admission (T0) and discharge (T1) after a period spent in a dust-mite-free environment (Misurina, Italian Dolomites, 1756 m). PletM showed a reduction from 29.48°C at T0 to 29.13°C at T1 (p = 0.17); DLCO passed from 93 to 102 (p = 0.085). FeNO mean value was 29.7 ppb at admission and 18.9 ppb at discharge (p = 0.014). Eosinophil mean count in induced sputum was 4 at T0 and 2 at T1 (p = 0.004). Spearman standardization coefficient beta was 0.414 between eosinophils and FeNO and -0.278 between eosinophils and DLCO. Pearson’s correlation index between DLCO and PletM was -0.456 (p = 0.019). A negative correlation between DLCO and PletM was found. However, DLCO did not show a significant correlation with FeNO and eosinophils in the airways. Additional studies are needed to clarify the role of DLCO as a potential tool in monitoring childhood asthma.
PMID: 23342292 [PubMed – in process]
View full post on pubmed: asthma
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BWMC Sponsors 'Camp Airways' for Children with Asthma
Patch.com Sponsored by the Baltimore Washington Medical Center (BWMC), campers will participate in a range of activities including asthma and nutrition education, arts and crafts, swimming and other outdoor activities, according to the website. The goal of the … |
View full post on asthma – Google News
 MD News (press release) |
Remodeling Asthma Patients' Airways
Ivanhoe (Ivanhoe Newswire) — Asthma is a common chronic respiratory condition characterized clinically by an excessive tendency toward reversible airway narrowing. Scientists believe that the airway narrowing induced by allergen exposure in patients with … Research revelation could shape future long-term treatment of asthma Frequent Bronchoconstriction Tied to Airway Remodeling |
View full post on asthma – Google News
Increased apoptosis of CD4 and CD8 T lymphocytes in the airways of horses with recurrent airway obstruction.
Vet Res Commun. 2011 May 19;
Authors: Moran G, Buechner-Maxwell VA, Folch H, Henriquez C, Galecio JS, Perez B, Carrasco C, Barria M
Recurrent airway obstruction (RAO, also known as equine heaves) is an inflammatory condition similar to human asthma caused by exposure of susceptible horses to poorly ventilated stable environments. The disease is characterized by neutrophilic airway inflammation, mucus hypersecretion and reversible bronchoconstriction. This inflammatory process is mediated by several factors, including antibodies, cytokines, resident cells of the airway and inflammatory cellular components that arrive in the respiratory tract. An increasing body of evidence has lent support to the concept that a dysregulation of T cell apoptosis may play a central role in the development of airway inflammation and the associated asthma. Therefore, the aim of this study was to investigate early and late apoptosis of CD4 and CD8 T cell subpopulations obtained from the airways of acute RAO-positive animals after exposure to hay/straw. The percentages of CD4 and CD8 T cells and their associated frequencies of apoptosis were quantified using flow cytometry. Hay/straw exposure induced clinical airway obstruction, airway neutrophilia and increased airway mucus production in RAO-positive horses. In addition, allergen exposure increased the percentage of CD4 T cells in RAO-positive horses as well as the frequency of early and late apoptosis in both CD4 and CD8 lymphocyte subpopulations. These results suggest that the higher frequency of lymphocyte apoptosis may play a role in disease progression of horses afflicted with RAO and may partially explain the characteristic remission of this pathological condition once the allergen source is removed. However, further studies are needed to clarify the role of T cell apoptosis in RAO-affected horses.
PMID: 21594641 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
 Health Newstrack |
ATS: What's Bitter to Taste Might Ease Tight Airways
MedPage Today DENVER — What's bitter on the tongue may be sweet relief to people suffering from asthma and COPD, a researcher said here. A wide-ranging analysis of genes expressed in lung tissue has … Researchers a step closer to find new class of asthma, COPD drugs Researchers move closer to identifying new class of asthma, COPD drugs Bitter May Be Better When It Comes to Bronchodilation |
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Asthma may be linked to bacterial colonies in our airways
Milwaukee Journal Sentinel (blog) "People thought that asthma was caused by inhalation of allergens but this study shows that it may be more complicated than that," said Homer Boushey, a professor of medicine at the University of California, San Francisco and one of the authors of a … Asthma linked to bacterial communities |
View full post on asthma – Google News