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Condition: Asthma
Intervention: Biological: Segmental airway allergen challenge
Sponsors: University of California, San Francisco; National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting – verified August 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
| Related Articles |
IL-33 and Thymic Stromal Lymphopoietin Mediate Immune Pathology in Response to Chronic Airborne Allergen Exposure.
J Immunol. 2014 Jul 11;
Authors: Iijima K, Kobayashi T, Hara K, Kephart GM, Ziegler SF, McKenzie AN, Kita H
Abstract
Humans are frequently exposed to various airborne allergens in the atmospheric environment. These allergens may trigger a complex network of immune responses in the airways, resulting in asthma and other chronic airway diseases. In this study, we investigated the immunological mechanisms involved in the pathological changes induced by chronic exposure to multiple airborne allergens. Naive mice were exposed intranasally to a combination of common airborne allergens, including the house dust mite, Alternaria, and Aspergillus, for up to 8 wk. These allergens acted synergistically and induced robust eosinophilic airway inflammation, specific IgE Ab production, type 2 cytokine response, and airway hyperresponsiveness in 4 wk, followed by airway remodeling in 8 wk. Increased lung infiltration of T cells, B cells, and type 2 innate lymphoid cells was observed. CD4(+) T cells and type 2 innate lymphoid cells contributed to the sources of IL-5 and IL-13, suggesting involvement of both innate and adaptive immunity in this model. The lung levels of IL-33 increased quickly within several hours after allergen exposure and continued to rise throughout the chronic phase of inflammation. Mice deficient in IL-33R (Il1rl1(-/-)) and thymic stromal lymphopoietin receptor (Tslpr(-/-)) showed significant reduction in airway inflammation, IgE Ab levels, and airway hyperresponsiveness. In contrast, mice deficient in IL-25R or IL-1R showed minimal differences as compared with wild-type animals. Thus, chronic exposure to natural airborne allergens triggers a network of innate and adaptive type 2 immune responses and airway pathology, and IL-33 and thymic stromal lymphopoietin most likely play key roles in this process.
PMID: 25015831 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Medscape |
First-Year Allergen Exposure Reduces Asthma, Allergy Risk
Monthly Prescribing Reference Exposure to specific allergens and bacteria during the first year of life could reduce the risk of recurrent wheeze and allergic sensitization. Published in the Journal of Allergy and Clinical Immunology, 560 children at high risk for asthma were … Increased airway resistance in early childhood linked to asthma Newborns exposed to dirt have lower allergy, asthma risk |
View full post on asthma – Google News
Guardian Liberty Voice |
Asthma and Allergy Protection Possible From Early Allergen Exposure
Guardian Liberty Voice A recent study done by scientists at the Johns Hopkins Children's Center has shown that babies who are exposed early to allergens could be protected from allergies and asthma later in life. Allergens include pollen, household bacteria, pet dander and … |
View full post on asthma – Google News
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Mother's illness, allergen exposure during pregency may predict child's risk …
News-Medical.net The study, published in the February issue of Annals of Allergy, Asthma and Immunology, found a mother's infections and bacterial exposure during pregnancy affect the in utero environment, thus increasing a baby's risk of developing allergy and asthma … |
View full post on asthma – Google News
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Mother's illness, allergen exposure may predict child's risk of asthma
News-Medical.net The study, published in the February issue of Annals of Allergy, Asthma and Immunology, found a mother's infections and bacterial exposure during pregnancy affect the in utero environment, thus increasing a baby's risk of developing allergy and asthma … |
View full post on asthma – Google News
Condition: Allergic Rhinitis
Interventions: Drug: Grazax; Drug: Grazax Placebo
Sponsors: Imperial College London; King’s College London; ALK-Abelló A/S; Wellcome Trust
Not yet recruiting – verified December 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Asthma
Interventions: Drug: Clopidogrel; Drug: Placebo
Sponsors: University of Southampton; University of Southampton
Recruiting – verified September 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Asthma
Interventions: Drug: Low-Dose MK-8351; Drug: High-Dose MK-8351; Drug: Placebo to MK-8351
Sponsors: Merck; Merck
Not yet recruiting – verified August 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
| Related Articles |
Comparative proteomics of inhaled silver nanoparticles in healthy and allergen provoked mice.
Int J Nanomedicine. 2013;8:2783-99
Authors: Su CL, Chen TT, Chang CC, Chuang KJ, Wu CK, Liu WT, Ho KF, Lee KY, Ho SC, Tseng HE, Chuang HC, Cheng TJ
Abstract
BACKGROUND: Silver nanoparticles (AgNPs) have been associated with the exacerbation of asthma; however, the immunological basis for the adjuvant effects of AgNPs is not well understood.
OBJECTIVE: The aim of the study reported here was to investigate the allergic effects of AgNP inhalation using proteomic approaches.
METHODS: Allergen provoked mice were exposed to 33 nm AgNPs at 3.3 mg/m(3). Following this, bronchoalveolar lavage fluid (BALF) and plasma were collected to determine protein profiles.
RESULTS: In total, 106 and 79 AgNP-unique proteins were identified in the BALF of control and allergic mice, respectively. Additionally, 40 and 26 AgNP-unique proteins were found in the plasma of control and allergic mice, respectively. The BALF and plasma protein profiles suggested that metabolic, cellular, and immune system processes were associated with pulmonary exposure to AgNPs. In addition, we observed 18 proteins associated with systemic lupus erythematosus that were commonly expressed in both control and allergic mice after AgNP exposure. Significant allergy responses were observed after AgNP exposure in control and allergic mice, as determined by ovalbumin-specific immunoglobulin E.
CONCLUSION: Inhaled AgNPs may regulate immune responses in the lungs of both control and allergic mice. Our results suggest that immunology is a vital response to AgNPs.
PMID: 23946650 [PubMed – in process]
View full post on pubmed: asthma