Tag: allergens

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Math-free guides for glycerin and allergens at variable subcutaneous injection volumes: How’s my dosing? Update.

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Math-free guides for glycerin and allergens at variable subcutaneous injection volumes: How’s my dosing? Update.

Ann Allergy Asthma Immunol. 2016 Mar 24;

Authors: Grier TJ, Converse LM, Rekkerth DJ, Renahan KE

Abstract
BACKGROUND: Current summaries of effective maintenance dose ranges for subcutaneous immunotherapy (SCIT) are based on administration of 0.5-mL volumes. Extract formulations delivering equivalent dose ranges for practices using different injection volumes have not been reported, and calculation of the final glycerin concentrations in these solutions remains an inconvenient and repetitive process.
OBJECTIVES: To create math-free guides for allergen doses and glycerin concentrations that identify the extract concentrate volumes required to deliver doses within the ranges cited in the 2011 immunotherapy practice parameters for clinicians using 5.0-mL maintenance vials and injection volumes ranging from 0.2 to 1.0 mL.
METHODS: Algebraic calculations were performed to determine the specific combinations of extract concentrate strengths, volumes of these products in patient vaccines, and injection volumes needed for administration of target allergen doses spanning the current SCIT practice parameter recommendations.
RESULTS: For each product or group (nonstandardized extracts), tables were constructed to define the allergen doses provided by various combinations of extract concentrate volumes and injection volumes. The values within the effective dose ranges for each product were highlighted to facilitate comparisons of specific conditions relevant to allergy specialists. Glycerin tables were also created to permit convenient assessments of the final concentrations of this stabilizer in patient prescriptions.
CONCLUSIONS: SCIT dosing and glycerin tables are useful tools to assist allergists with practice decisions that involve variable patient formulas and injection volumes and can help identify suitable conditions for treatment of patients presenting with diverse allergen sensitivities and specificity profiles.

PMID: 27017565 [PubMed – as supplied by publisher]

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Alternaria alternata allergens: Markers of exposure, phylogeny and risk of fungi-induced respiratory allergy.

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Alternaria alternata allergens: Markers of exposure, phylogeny and risk of fungi-induced respiratory allergy.

Environ Int. 2016 Jan 27;89-90:71-80

Authors: Gabriel MF, Postigo I, Tomaz CT, Martínez J

Abstract
Alternaria alternata spores are considered a well-known biological contaminant and a very common potent aeroallergen source that is found in environmental samples. The most intense exposure to A. alternata allergens is likely to occur outdoors; however, Alternaria and other allergenic fungi can colonize in indoor environments and thereby increase the fungal aeroallergen exposure levels. A consequence of human exposure to fungal aeroallergens, sensitization to A. alternata, has been unequivocally associated with increased asthma severity. Among allergenic proteins described in this fungal specie, the major allergen, Alt a 1, has been reported as the main elicitor of airborne allergies in patients affected by a mold allergy and considered a marker of primary sensitization to A. alternata. Moreover, A. alternata sensitization seems to be a triggering factor in the development of poly-sensitization, most likely because of the capability of A. alternata to produce, in addition to Alt a 1, a broad and complex array of cross-reactive allergens that present homologs in several other allergenic sources. The study and understanding of A. alternata allergen information may be the key to explaining why sensitization to A. alternata is a risk factor for asthma and also why the severity of asthma is associated to this mold. Compared to other common environmental allergenic sources, such as pollens and dust mites, fungi are reported to be neglected and underestimated. The rise of the A. alternata allergy has enabled more research into the role of this fungal specie and its allergenic components in the induction of IgE-mediated respiratory diseases. Indeed, recent research on the identification and characterization of A. alternata allergens has allowed for the consideration of new perspectives in the categorization of allergenic molds, assessment of exposure and diagnosis of fungi-induced allergies.

PMID: 26826364 [PubMed – as supplied by publisher]

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Allergy to hedgehog with carboxypeptidase and chitinase-like and chymotrypsin-like elastase family members as the relevant allergens.

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Allergy to hedgehog with carboxypeptidase and chitinase-like and chymotrypsin-like elastase family members as the relevant allergens.

Ann Allergy Asthma Immunol. 2016 Jan 7;

Authors: González-de-Olano D, Muñoz-García E, Haroun-Díaz E, Bartolomé B, Pastor-Vargas C

PMID: 26774975 [PubMed – as supplied by publisher]

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Indoor winter allergy risks, stopping asthma, rhinitis causing allergens in … – Bel Marra Health


Bel Marra Health

Indoor winter allergy risks, stopping asthma, rhinitis causing allergens in …
Bel Marra Health
Indoor winter allergy risks, stopping asthma, rhinitis causing allergens in your home The risk of winter allergies can be lowered by preventing the allergens that cause asthma and rhinitis. Although the springtime is more commonly known to produce …

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Growing Up On A Farm Protects Against Allergens And Asthma – Design & Trend


Design & Trend

Growing Up On A Farm Protects Against Allergens And Asthma
Design & Trend
People who grew up on a farm are far less likely to suffer from allergies and asthma, writes Nature World News. That's according to researchers from the Vlaams Instituut voor Biotechnologie (VIB) and Ghent University who have found a link between …
Here's why farm kids have fewer allergies and less asthmaThe Verge
Dirty farm air may ward off asthma in childrenScience /AAAS
Here's How Dirt Might Protect Kids From AsthmaWMTV
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