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Exposure to Antibiotics Linked to Severity of Allergic Asthma
Bioscience Technology Widely used antibiotics may increase incidence and severity of allergic asthma in early life, according to a University of British Columbia study. The study, published in the journal EMBO reports, shows that certain antibiotics that affect intestinal … |
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Treating symptoms of allergic rhinitis improved asthma outcomes
Pediatric SuperSite Allergic rhinitis and asthma may be considered as manifestations of one syndrome that has a wide spectrum of severity, according to data presented here during the American Academy of Allergy, Asthma & Immunology 2012 Annual Meeting. |
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Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort.
Thorax. 2012 Feb 14;
Authors: Leynaert B, Sunyer J, Garcia-Esteban R, Svanes C, Jarvis D, Cerveri I, Dratva J, Gislason T, Heinrich J, Janson C, Kuenzli N, de Marco R, Omenaas E, Raherison C, Gómez Real F, Wjst M, Zemp E, Zureik M, Burney PG, Anto JM, Neukirch F
Abstract
BackgroundAlthough women with severe non-allergic asthma may represent a substantial proportion of adults with asthma in clinical practice, gender differences in the incidence of allergic and non-allergic asthma have been little investigated in the general population.MethodsGender differences in asthma prevalence, reported diagnosis and incidence were investigated in 9091 men and women randomly selected from the general population and followed up after 8-10 years as part of the European Community Respiratory Health Survey. The protocol included assessment of bronchial responsiveness, IgE specific to four common allergens and skin tests to nine allergens.ResultsAsthma was 20% more frequent in women than in men over the age of 35 years. Possible under-diagnosis of asthma appeared to be particularly frequent among non-atopic individuals, but was as frequent in women as in men. The follow-up of subjects without asthma at baseline showed a higher incidence of asthma in women than in men (HR 1.94; 95% CI 1.40 to 2.68), which was not explained by differences in smoking, obesity or lung function. More than 60% of women and 30% of men with new-onset asthma were non-atopic. The incidence of non-allergic asthma was higher in women than in men throughout all the reproductive years (HR 3.51; 95% CI 2.21 to 5.58), whereas no gender difference was observed for the incidence of allergic asthma.ConclusionsThis study shows that female sex is an independent risk factor for non-allergic asthma, and stresses the need for more careful assessment of possible non-allergic asthma in clinical practice, in men and women.
PMID: 22334535 [PubMed – as supplied by publisher]
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[The approaches to diagnostics and therapy of allergic rhinitis].
Vestn Otorinolaringol. 2011;(5):62-5
Authors:
Abstract
Allergic rhinitis is a common disease of great socio-economic significance. The treatment of this condition is carried out on an individual basis depending on the clinical course of the disease; it includes prevention of contacts with the allergen, medicamental and immunotherapy. The principal pharmaceuticals used to treat the patients include oral and intranasal H1 anti-histaminic preparations, intranasal corticosteroids, intranasal cromones, anti-leukotrien agents, and specific subcutaneous immunotherapy. Glencet (levocetirizine) is one of the modern antihistaminic preparations of the second generation having an advantage over other drugs for the treatment of allergic rhinitis in that it may be prescribed to the patients presenting with concomitant bronchial asthma and cardiac diseases.
PMID: 22334929 [PubMed – in process]
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Exposure to common environmental bacteria may be source of some allergic …
EurekAlert (press release) Could some cases of asthma actually be caused by an allergic reaction to a common environmental bacteria? New research findings published in the Journal of Leukocyte Biology (https://www.jleukbio.org) suggests that this idea may not be as far-fetched … |
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Campaign touts Megann's Law to protect allergic children
Montreal Gazette A newly formed grassroots coalition wants a uniform policy for all schools in Quebec for managing food allergy and asthma cases and is campaigning for the Quebec government to adopt Megann's Law. "I am anxious to see where it will lead," Josée Ayotte … |
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Allergic and Asthma Crises in Our Schools: Coalition Calls for Adoption of …
Canada NewsWire (press release) 11, 2012 /CNW Telbec/ – Megann Ayotte Lefort was only 6 years old when she suffered a fatal allergic and asthmatic reaction at her Montreal school. Now a grassroots association of allergy and asthma advocates has formed around a single and vital goal: … |
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 Daily Mail |
Could you be allergic to your Christmas tree?
New Zealand Herald He and his team found 53 different kinds of mould present on 23 samples, according to the research published in the Annals of Allergy, Asthma and Immunology. These weren't everyday mould – 70 per cent were of the type that can trigger asthma attacks, … Merry Moldmas? |
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Inflammasome – IL-1 – Th17 response in allergic lung inflammation.
J Mol Cell Biol. 2011 Dec 6;
Authors: Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, Le Bert M, Quesniaux V, Ryffel B
Abstract
Allergic asthma has increased dramatically in prevalence and severity over the last three decades. Both clinical and experimental data support an important role of Th2 cell response in the allergic response. Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid activating the NLRP3 inflammasome complex and caspase-1 cleaving pro-IL-1? to mature IL-1?. The production of pro-IL-1? requires a TLR4 signal which is provided by the allergen. IL-1? creates a pro-inflammatory milieu with the production of IL-6 and chemokines which mobilize neutrophils and enhance Th17 cell differentiation in the lung. Here, we review our results showing that NLRP3 inflammasome activation is required to develop allergic airway inflammation in mice and that IL-17 and IL-22 production by Th17 plays a critical role in established asthma. Therefore, inflammasome activation leading to IL-1? production contributes to the control of allergic asthma by enhancing Th17 cell differentiation.
PMID: 22147847 [PubMed – as supplied by publisher]
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Bedside airflow device effective in allergic asthma
6minutes A bedside cooled airflow device that displaces allergens from the “breathing space” during sleep may benefit patients with allergic asthma, UK researchers have shown. While many allergen avoidance strategies have … Breathe Easier With Asthma While You Sleep |
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