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Discovery improves understanding of factors that trigger allergic asthma
News-Medical.net However, if these regulatory mechanisms malfunction the cells of the immune system attack innocuous substances which enter the body from the environment, ultimately leading to the development of atopic diseases such as allergic asthma. In western … |
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Conditions: Dermatitis, Atopic; Asthma; Healthy
Intervention: Other: Allergic Skin Reaction (ASR) Testing and Skin Blister Induction
Sponsor: Janssen Research & Development, LLC
Not yet recruiting – verified January 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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New cellular pathway triggering allergic asthma response identified
Medical Xpress Researchers at the University of California, San Diego School of Medicine, with collaborators in Korea and Scotland, have identified a novel signaling pathway critical to the immune response of cells associated with the initiation of allergic asthma. |
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New Cellular Pathway Triggering Allergic Asthma Response Identified
UCSD Medical Center Researchers at the University of California, San Diego School of Medicine, with collaborators in Korea and Scotland, have identified a novel signaling pathway critical to the immune response of cells associated with the initiation of allergic asthma. |
View full post on asthma – Google News
Conditions: Rhinitis; Rhinoconjunctivitis; Asthma
Interventions: Biological: DP/MG/14-1; Biological: DP/MG/14-2
Sponsor: Laboratorios Leti, S.L.
Recruiting – verified January 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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SLIT-tablet seems safe for patients with asthma, allergic rhinitis
Clinical Advisor HealthDay News — For patients with asthma and allergic rhinitis with/without conjunctivitis (AR/C), treatment with a Timothy grass sublingual immunotherapy tablet (SLIT-tablet) may be safe, results of research published in Allergy indicate. Using data … Sublingual immunotherapy tablet safe in asthma patients |
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IL-10 and Regulatory T Cells Cooperate in Allergen-Specific Immunotherapy To Ameliorate Allergic Asthma.
J Immunol. 2014 Dec 19;
Authors: Böhm L, Maxeiner J, Meyer-Martin H, Reuter S, Finotto S, Klein M, Schild H, Schmitt E, Bopp T, Taube C
Abstract
Human studies demonstrated that allergen-specific immunotherapy (IT) represents an effective treatment for allergic diseases. IT involves repeated administration of the sensitizing allergen, indicating a crucial contribution of T cells to its medicinal benefit. However, the underlying mechanisms of IT, especially in a chronic disease, are far from being definitive. In the current study, we sought to elucidate the suppressive mechanisms of IT in a mouse model of chronic allergic asthma. OVA-sensitized mice were challenged with OVA or PBS for 4 wk. After development of chronic airway inflammation, mice received OVA-specific IT or placebo alternately to airway challenge for 3 wk. To analyze the T cell-mediated mechanisms underlying IT in vivo, we elaborated the role of T-bet-expressing Th1 cells, T cell-derived IL-10, and Ag-specific thymic as well as peripherally induced Foxp3(+) regulatory T (Treg) cells. IT ameliorated airway hyperresponsiveness and airway inflammation in a chronic asthma model. Of note, IT even resulted in a regression of structural changes in the airways following chronic inhaled allergen exposure. Concomitantly, IT induced Th1 cells, Foxp3(+), and IL-10-producing Treg cells. Detailed analyses revealed that thymic Treg cells crucially contribute to the effectiveness of IT by promoting IL-10 production in Foxp3-negative T cells. Together with the peripherally induced Ag-specific Foxp3(+) Treg cells, thymic Foxp3(+) Treg cells orchestrate the curative mechanisms of IT. Taken together, we demonstrate that IT is effective in a chronic allergic disease and dependent on IL-10 and thymic as well as peripherally induced Ag-specific Treg cells.
PMID: 25527785 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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Many Misuse Devices for Asthma, Allergic Reaction
WebMD THURSDAY, Dec. 18, 2014 (HealthDay News) — Few people know how to properly use the medical devices that contain lifesaving medications for severe allergic reactions and asthma attacks, a new study shows. Just 16 percent knew the correct way to use … Study: Very few use EpiPen, asthma inhalers correctly Study shows epinephrine auto-injectors and asthma inhalers used incorrectly Correct Use of Asthma, Allergy Devices Could Save Lives |
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Is SLIT-Tablet Tx Safe for Asthma Patients with Allergic Rhinitis?
Monthly Prescribing Reference All subjects had a confirmed diagnosis of grass-pollen-induced AR/C with or without controlled asthma and a history of medication use to treat symptoms of AR/C during the previous pollen season. A total of 3,314 adult patients and 881 pediatric … |
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Paeoniflorin attenuates allergic inflammation in asthmatic mice.
Int Immunopharmacol. 2014 Nov 26;
Authors: Sun J, Wu J, Xu C, Luo Q, Li B, Dong J
Abstract
Paeoniflorin (PF), one of the major active ingredients of Chinese peony, has demonstrated anti-inflammatory and immunoregulatory effects. However, it has remained unclear whether PF treatment can inhibit allergic inflammation in asthma. In this study, we evaluated the effects of PF on pulmonary function and airway inflammation in asthmatic mice. The allergic asthma models were established in BALB/c mice. The mice were sensitized and challenged with ovalbumin. Airway hyperresponsiveness was detected by direct airway resistance analysis. Lung tissues were examined for inflammatory cell infiltration. IL-5, IL-13, IL-17, and eotaxin in bronchoalveolar lavage fluid (BALF) and their mRNA expression in lung tissue were examined by ELISA and realtime PCR, respectively. The total IgE level in serum was measured by ELISA. The protein expression of p-ERK and p-JNK was detected by western blot. Our data showed that PF oral administration significantly reduced airway hyperresponsiveness to aerosolized methacholine and decreased IL-5, IL-13, IL-17 and eotaxin levels in the BALF, and decreased IgE level in the serum. Histological studies showed that PF administration markedly decreased inflammatory infiltration. Similarly, treatment with PF significantly inhibited IL-5, IL-13, IL-17 and eotaxin mRNA expression in lung tissues. The protein expression levels of p-ERK and p-JNK were substantially decreased after oral administration of PF. In summary, PF displayed anti-inflammatory effects in the OVA-induced asthmatic model by decreasing the expression of IL-5, IL-13, IL-17 and eotaxin. These effects were mediated at least partially by inhibiting the activation of MAPK pathway.
PMID: 25433342 [PubMed – as supplied by publisher]
View full post on pubmed: asthma