US Asthma Drugs Market to 2015 Analysis and Forecast to 2019 – Medgadget.com (blog)

US Asthma Drugs Market to 2015 Analysis and Forecast to 2019
Medgadget.com (blog)
WiseGuy-Reports178 Asthma is a disease that affects the lungs and is characterized by wheezing, coughing, breathlessness, and chest tightness. It is a chronic ailment of the respiratory tract, which is caused by the obstruction of the flow of air and …

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Global and China Asthma Therapeutics Industry 2013 Market Analysis, Growth … – Medgadget.com (blog)

Global and China Asthma Therapeutics Industry 2013 Market Analysis, Growth
Medgadget.com (blog)
Mrrbiz-Logo2119 “The Report Global and China Asthma Therapeutics Industry 2013 Market Research Report provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. – MarketResearchReports.biz”.

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PharmaPoint: Asthma – Japan Drug Forecast and Market Analysis to 2023 … – Medgadget.com (blog)

PharmaPoint: Asthma – Japan Drug Forecast and Market Analysis to 2023
Medgadget.com (blog)
The Report PharmaPoint: Asthma – Japan Drug Forecast and Market Analysis to 2023 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. – MarketResearchReports.biz. Asthma accounts for …

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Cinquil (Reslizumab) (Asthma) – Forecast and Market Analysis to 2023: Research … – Medgadget.com (blog)

Cinquil (Reslizumab) (Asthma) – Forecast and Market Analysis to 2023: Research
Medgadget.com (blog)
The Report Cinquil (Reslizumab) (Asthma) – Forecast and Market Analysis to 2023 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. – MarketResearchReports.biz. GlobalData has released …

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Fluticasone Furoate (Asthma) – Forecast and Market Analysis to 2023: Research … – Medgadget.com (blog)

Fluticasone Furoate (Asthma) – Forecast and Market Analysis to 2023: Research
Medgadget.com (blog)
The Report Fluticasone Furoate (Asthma) – Forecast and Market Analysis to 2023 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. – MarketResearchReports.biz. GlobalData has released

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Analysis of asthma patients for cryptococcal seroreactivity in an urban German area.

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Analysis of asthma patients for cryptococcal seroreactivity in an urban German area.

Med Mycol. 2015 May 30;

Authors: Grahnert A, Müller U, von Buttlar H, Treudler R, Alber G

Abstract
Cryptococcus neoformans is an opportunistic fungal pathogen that causes lung inflammation and meningoencephalitis in immunocompromised patients but is also able to asymptomatically infect immunocompetent individuals. C. neoformans is found ubiqui-tously especially in urban areas where it is spread by pigeons, and fungal exposure may predispose for asthma development already at an early age, as soon as confronted with pigeon droppings. In the study presented here, we investigated the presence of specific immunoglobulin G (IgG) against C. neoformans in sera from patients suffering from asthma in comparison to a healthy control cohort, accrued from the Leipzig Research Centre for Civilization Diseases (LIFE). For serological analysis we developed a flow cytometry (FACS) based assay specific for an acapsular strain of C. neoformans to comprehensively analyze different cryptococcal serotypes. Compared with the non-asthmatic cohort, asthmatics exhibited, as expected, an elevated level of total serum immunoglobulin E (IgE), whereas the IgG seroreactivity against C. neoformans was not significantly different among the two groups (P = .118). Nevertheless, there was a trend toward increased Cryptococcus-specific IgG antibodies in the serum of asthmatics. Additionally, in male asthmatics an increased IgG-mediated seroreactivity compared to female asthmatics was found. This points to a higher prevalence of subclinical C. neoformans infection in male asthmatics and may support the hypothesis of C. neoformans as a risk factor for the development of asthma in urban areas.

PMID: 26026172 [PubMed – as supplied by publisher]

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Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.

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Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.

J Allergy Clin Immunol. 2015 Apr 9;

Authors: Persson H, Kwon AT, Ramilowski JA, Silberberg G, Söderhäll C, Orsmark-Pietras C, Nordlund B, Konradsen JR, de Hoon MJ, Melén E, Hayashizaki Y, Hedlin G, Kere J, Daub CO

Abstract
BACKGROUND: Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, such as smoking or allergies, are found after extensive investigation, these children are given a diagnosis of therapy-resistant (or therapy-refractory) asthma (SA).
OBJECTIVE: We sought to deepen our understanding of childhood SA by analyzing gene expression and modeling the underlying regulatory transcription factor networks in peripheral blood leukocytes.
METHODS: Gene expression was analyzed by using Cap Analysis of Gene Expression in children with SA (n = 13), children with controlled persistent asthma (n = 15), and age-matched healthy control subjects (n = 9). Cap Analysis of Gene Expression sequencing detects the transcription start sites of known and novel mRNAs and noncoding RNAs.
RESULTS: Sample groups could be separated by hierarchical clustering on 1305 differentially expressed transcription start sites, including 816 known genes and several novel transcripts. Ten of 13 tested novel transcripts were validated by means of RT-PCR and Sanger sequencing. Expression of RAR-related orphan receptor A (RORA), which has been linked to asthma in genome-wide association studies, was significantly upregulated in patients with SA. Gene network modeling revealed decreased glucocorticoid receptor signaling and increased activity of the mitogen-activated protein kinase and Jun kinase cascades in patients with SA.
CONCLUSION: Circulating leukocytes from children with controlled asthma and those with SA have distinct gene expression profiles, demonstrating the possible development of specific molecular biomarkers and supporting the need for novel therapeutic approaches.

PMID: 25863981 [PubMed – as supplied by publisher]

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A Competitive Analysis of the Global Asthma and COPD Therapeutics Market … – MarketWatch

A Competitive Analysis of the Global Asthma and COPD Therapeutics Market
MarketWatch
oBenralizumab, a monoclonal antibody jointly being developed by MedImmune and AstraZeneca in Phase 3 trials. Benralizumab is bound to the interleukin-5 receptor (IL-5R?) and is being evaluated to help asthma control and reduce the onset of asthmatic …

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