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Coronary spasm secondary to biphasic anaphylaxis after hymenoptera stings.
Ann Allergy Asthma Immunol. 2016 Jun 1;
Authors: Blasco-Navalpotro MÁ, Orejas-Gallego A, Flordelís-Lasierra JL, Prior-Gómez N, Jiménez-Jiménez J, Seoane-Leston FJ
PMID: 27263087 [PubMed – as supplied by publisher]
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The Sydney Morning Herald |
Teenagers with asthma have increased risk of anaphylaxis, study finds
The Sydney Morning Herald "If a person is coughing, wheezing or experiencing breathing difficulties, sometimes it can be hard to work out if they are having an asthma attack or having anaphylaxis," said lead researcher Professor Katie Allen, from the Murdoch Children's Research … Do not inhale Allergies or a cold? How to know the difference to treat symptoms properly |
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Anaphylaxis in children.
Curr Opin Pediatr. 2016 Mar 8;
Authors: Farbman KS, Michelson KA
Abstract
PURPOSE OF REVIEW: Anaphylaxis is a serious allergic reaction that can be life threatening. We will review the most recent evidence regarding the diagnosis, treatment, monitoring, and prevention of anaphylaxis in children.
RECENT FINDINGS: Histamine and tryptase are not sufficiently accurate for the routine diagnosis of anaphylaxis, so providers should continue to rely on clinical signs. Platelet-activating factor shows some promise in the diagnosis of anaphylaxis. Intramuscular is the best route for epinephrine administration for children of all weights. Glucocorticoids may reduce prolonged hospitalizations for anaphylaxis. Children with anaphylaxis who have resolving symptoms and no history of asthma or previous biphasic reactions may be observed for as few as 3-4?h before emergency department discharge. Early peanut introduction reduces the risk of peanut allergy.
SUMMARY: Epinephrine remains the mainstay of anaphylaxis treatment, and adjuvant medications should not be used in its place. All patients with anaphylaxis should be prescribed and trained to use an epinephrine autoinjector. Clinically important biphasic reactions are rare. Observation in the emergency department for most anaphylaxis patients is recommended, with the duration determined by risk factors. Admission is reserved for patients with unimproved or worsening symptoms, or prior biphasic reaction.
PMID: 26963947 [PubMed – as supplied by publisher]
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Allergic Living |
Why Does Asthma Put a Food-Allergic Child at a Higher Risk of Anaphylaxis?
Allergic Living It is assumed that people with food allergy who have asthma are more likely to experience severe food-allergic reactions because the airways are already prone to respond with narrowing. Therefore, if you have two people with the same sensitivity to a … 5 Secret Ways Spring Allergies Are Affecting Your Body Allergies kicking up? You're not alone Sorry, allergy sufferers, but you still have another month of the yellow death |
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Oral Immunotherapy Linked to Anaphylaxis in Teens with Asthma
HCPLive Moreover, they wrote, the fact that 3 of just 13 asthmatic adolescents in the study developed life-threatening anaphylaxis, and that all of the cases seemed to stem from their failure to follow medical directives, suggests that doctors should regard … |
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OIT triggered life-threatening anaphylaxis in teenagers with asthma
Healio Teenagers with persistent asthma, high milk- or egg-specific IgE levels and noncompliant behavior were a high-risk group for oral immunotherapy and experienced life-threatening reactions to the treatment, according to recent study results. Researchers … |
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COPD, asthma linked to poor anaphylaxis outcomes
medwireNews medwireNews: Researchers have found that patients with chronic lung diseases, including asthma and chronic obstructive pulmonary disease (COPD), are significantly more likely to have poor outcomes when hospitalized for anaphylaxis and other allergic … |
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SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis.
PLoS One. 2013;8(2):e55763
Authors: Zhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z
Abstract
Allergic inflammation and severe allergic reactions (anaphylaxis) are important in allergen induced diseases. Bacterial products such as lipopolysaccharide (LPS) are ubiquitous and can facilitate allergen induced Th2 immune responses. Phosphatase SHP-1 is critical in regulating immunological homeostasis and in allergen induced Th2 immune responses in the lung. However, the mechanisms underlying the initiation of allergic inflammation and allergen induced anaphylaxis are still not completely elucidated and it is unclear whether SHP-1 plays any role in LPS-induced airway inflammation and in allergen-induced anaphylaxis. In this study we tested the hypothesis that phosphatase SHP-1 plays an important role in allergic inflammation and anaphylaxis and determined whether its effects are through regulation of mast cell functions. SHP-1 deficient (mev/+ and mev/mev) and mast cell deficient (Kit(W-sh)) mice were examined in their responses to LPS airway stimulation and to ovalbumin (OVA) allergen induced systemic anaphylaxis. Compared to wild type mice, mev/+ mice had significantly enhanced LPS induced airway inflammation and OVA induced anaphylactic responses, including hypothermia and clinical symptoms. These changes were mast cell dependent as Kit(W-sh) mice had reduced responses whereas adoptive transfer of mast cells restored the responses. However, T and B cells were not involved and macrophages did not play a significant role in LPS induced airway inflammation. Interestingly, basophil differentiation from SHP-1 deficient bone marrow cells was significantly reduced. These findings provided evidence that through regulation of mast cell functions SHP-1 plays a critical role as a negative regulator in allergic inflammation and in allergen induced anaphylaxis. In addition, SHP-1 seems to be required for normal basophil development.
PMID: 23390550 [PubMed – in process]
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Back-To-School Asthma And Anaphylaxis Basics
MarketWatch (press release) "We want all school children, including those with asthma and anaphylaxis, a severe allergic reaction, to have full access to every academic and social opportunity available. It takes planning and good communication between the school and health care … |
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May 2012 Asthma and Anaphylaxis Legislative Report Reveals Active Bipartisan …
Sacramento Bee By Allergy & Asthma Network Mothers of Asthmatics McLEAN, Va., June 1, 2012 — /PRNewswire-USNewswire/ — "One thing is clear," said Nancy Sander, president and founder of Allergy & Asthma Network Mothers of Asthmatics (AANMA), "breathing is bipartisan … |
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