AntiInflammatory Archives - World Asthma Foundation

October 13, 2015

Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-?, IL-?, IL-6 and IL-17A.

Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-?, IL-?, IL-6 and IL-17A.

Immunobiology. 2015 Sep 8;

Authors: Charrad R, Berraïes A, Hamdi B, Ammar J, Hamzaoui K, Hamzaoui A

Abstract
BACKGROUND: The aim of this study was to assess interleukin (IL)-37 production in asthmatic children in serum and induced sputum and to look to the impact of IL-37 on pro-inflammatory cytokines production (TNF-?, IL-6, IL-1? and IL-17).
METHODS: Forty children with well-controlled asthma (20 moderate and 20 mild asthmatics) were studied. IL-37 was measured by ELISA in serum and induced sputum (IS) samples, and compared with 22 age- and sex-matched healthy controls. Real-time quantitative PCR was used to determine IL-37 mRNA expression in induced sputum cells. Induced sputum mononuclear cells from 10 moderate asthmatics and 10 healthy controls were stimulated either with lipopolysaccharides (LPS) or LPS plus recombinant IL-37 (rIL-37) comparing pro-inflammatory cytokines production. TNF-?, IL-1?, IL-6 and IL-17 were measured by RT-PCR and ELISA.
FINDINGS: The expression of IL-37 mRNA in asthmatic patients was significantly lower than that observed in healthy controls (P=0.0001). IL37 mRNA expression depended on asthma severity. Serum and IS IL-37 levels were significantly lower in asthma patients compared to healthy controls. LPS-stimulated sputum cells from asthma patients produced higher levels of IL-1?, IL-6, and TNF-? than those from HC. Adding rIL-37 suppressed TNF-?, IL-1? and IL-6 production in IS cells. In the same way, stimulating IS CD4(+) T cells in the presence of rIL-37 inhibited IL-17 production both in asthma patients and HC. IL-37 effect on IL-17 was more pronounced in patients than controls.
INTERPRETATION: The decrease in IL-37 level observed in IS was found to correlate with disease severity. The increased pro-inflammatory cytokines production from asthma IS cells was abrogated by the addition of rIL-37. IL-37 could be an important cytokine in the control of asthma by suppressing the production of inflammatory cytokines.

PMID: 26454413 [PubMed – as supplied by publisher]

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July 29, 2015

Anti-inflammatory H1 Antihistamines Allergic Rhinitis

Condition: Allergic Rhinitis
Interventions: Drug: Levocetirizine; Drug: Desloratadine
Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy
Completed – verified July 2015

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February 11, 2015

Allergy-Induced Asthma Thwarted by Anti-Inflammatory Drug – Lung Disease News

Lung Disease News

Allergy-Induced Asthma Thwarted by Anti-Inflammatory Drug
Lung Disease News
asthma Allergy-induced asthma may be prevented by a drug that acts on serotonin receptors, according to work from Louisiana State University Health New Orleans. Researchers at LSU showed that (R)-DOI, a “psychedelic” drug that activates serotonin …
Psychedelic drug prevents asthma in miceHealthCentral.com

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February 2, 2014

Structural insights into the interaction between a potent anti-inflammatory protein, vCCI, and the human CC chemokine, Eotaxin-1.

Structural insights into the interaction between a potent anti-inflammatory protein, vCCI, and the human CC chemokine, Eotaxin-1.

J Biol Chem. 2014 Jan 30;

Authors: Kuo NW, Gao YG, Schill MS, Isern N, Dupureur CM, Liwang PJ

Abstract
Chemokines play important roles in the immune system, not only recruiting leukocytes to the site of infection and inflammation but also guiding cell homing and cell development. The soluble poxvirus-encoded protein vCCI, a CC chemokine inhibitor, can bind to human CC chemokines tightly to impair the host immune defense. This protein has no known homologs in eukaryotes, and may represent a potent method to stop inflammation. Previously, our structure of the vCCI:MIP-1? complex indicated that vCCI uses negatively charged residues in ?-sheet II to interact with positively charged residues in the MIP-1? N-terminus,20’s region and 40’s loop. However, the interactions between vCCI and other CC chemokines have not yet been fully explored. Here, we used NMR and fluorescence anisotropy to study the interaction between vCCI and eotaxin-1 (CCL11), a CC chemokine that is an important factor in the asthma response. NMR results reveal that the binding pattern is very similar to the vCCI:MIP-1? complex, and suggest that electrostatic interactions provide a major contribution to binding. Fluorescence anisotropy results on variants of eotaxin-1 further confirm the critical roles of the charged residues in eotaxin. In addition, the binding affinity between vCCI and other wild type CC chemokines, MCP-1, MIP-1? and RANTES, were determined as 1.09 nM, 1.16 nM, and 0.22 nM, respectively. To our knowledge, this is the first work quantitatively measuring the binding affinity between vCCI and different CC chemokines.

PMID: 24482230 [PubMed – as supplied by publisher]

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August 19, 2013

Anti-Inflammatory Components of the Starfish Astropecten polyacanthus.

Anti-Inflammatory Components of the Starfish Astropecten polyacanthus.

Mar Drugs. 2013;11(8):2917-26

Authors: Thao NP, Cuong NX, Luyen BT, Quang TH, Hanh TT, Kim S, Koh YS, Nam NH, Van Kiem P, Van Minh C, Kim YH

Abstract
Inflammation is important in biomedical research, because it plays a key role in inflammatory diseases including rheumatoid arthritis and other forms of arthritis, diabetes, heart disease, irritable bowel syndrome, Alzheimer’s disease, Parkinson’s disease, allergies, asthma, and even cancer. In the present study, we describe the inhibitory effect of crude extracts and steroids isolated from the starfish Astropecten polyacanthus on pro-inflammatory cytokine (Interleukin-12 (IL-12) p40, interleukin-6 (IL-6), and tumor necrosis factor ? (TNF-?)) production in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs). Among those tested, compounds 5 and 7 showed potent inhibitory effects on the production of all three pro-inflammatory cytokines with IC50 values ranging from 1.82 ± 0.11 to 7.00 ± 0.16 ?M. Potent inhibitory activities were also observed for compound 1 on the production of IL-12 p40 and IL-6 with values of 3.96 ± 0.12 and 4.07 ± 0.13 ?M, respectively, and for compounds 3 and 4 on the production of IL-12 p40 with values of 6.55 ± 0.18 and 5.06 ± 0.16 ?M, respectively. Moreover, compounds 2 (IC50 = 34.86 ± 0.31 ?M) and 6 (IC50 = 79.05 ± 2.05 ?M) exhibited moderate inhibitory effects on the production of IL-12 p40, whereas compounds 3 (IC50 = 22.80 ± 0.21 ?M) and 4 (IC50 = 16.73 ± 0.25 ?M) moderately inhibited the production of TNF-? and IL-6, respectively.

PMID: 23945602 [PubMed – in process]

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July 17, 2012

Vitamin D Supplements Enhance The Anti-inflammatory Effect Of Steroids In … – Doctor Tipster

Vitamin D Supplements Enhance The Anti-inflammatory Effect Of Steroids In …
Doctor Tipster
The association between low vitamin D levels and asthma was made some time ago, but now researchers have shown that vitamin D deficiency is associated with a worse prognosis of asthma. The results were drawn from a multi-center study in which 1024 …

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June 7, 2012

Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism.

Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism.

Mediators Inflamm. 2012;2012:438912

Authors: Uzkeser H, Cadirci E, Halici Z, Odabasoglu F, Polat B, Yuksel TN, Ozaltin S, Atalay F

Abstract
The possible role of ?-2 adrenergic receptors in modulation of inflammatory and nociceptive conditions suggests that the ?-2 adrenergic receptor agonist, salbutamol, may have beneficial anti-inflammatory and analgesic effects. Therefore, in this study, we induced inflammatory and nociceptive responses with carrageenan-induced paw edema or cotton-pellet-induced granuloma models, both of which result in oxidative stress. We hypothesized that salbutamol would prevent inflammatory and nociceptive responses by stimulating ?-2 adrenergic receptors and the prevention of generation of ROS during the acute inflammation process in rats. Both doses of salbutamol used in the study (1 and 2?mg/kg) effectively blocked the acute inflammation and inflammatory nociception induced by carrageenan. In the cotton-pellet-induced granuloma test, both doses of salbutamol also significantly decreased the weight of granuloma tissue on the cotton pellets when compared to the control. Anti-inflammatory and analgesic effects of salbutamol were found to be comparable with those of indomethacin. Salbutamol decreased myeloperoxidase (MPO) activity and lipid peroxidation (LPO) level and increased the activity of superoxide dismutase (SOD) and level of glutathione (GSH) during the acute phase of inflammation. In conclusion, salbutamol can decrease acute and chronic inflammation, possibly through the stimulation of ?-2 adrenergic receptors. This anti-inflammatory effect may be of significance in asthma treatment, where inflammation also takes part in the etiopathology. This study reveals that salbutamol has significant antioxidative effects, which at least partially explain its anti-inflammatory capabilities. These findings presented here may also shed light on the roles of ?-2 adrenergic receptors in inflammatory and hyperalgesic conditions.

PMID: 22665951 [PubMed – in process]

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March 16, 2011

Revalesio to Present Research on the Anti-Inflammatory Effects of RNS60 in Asthma – Genetic Engineering News

Revalesio to Present Research on the Anti-Inflammatory Effects of RNS60 in Asthma
Genetic Engineering News
Revalesio Corporation announced today that research related to the use of RNS60, its novel anti-inflammatory, will be featured in two poster presentations at the Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI) in San …

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February 10, 2011