apnoea Archives - World Asthma Foundation

Loop gain in severely obese women with obstructive sleep apnoea.

Respir Physiol Neurobiol. 2015 Nov 15;

Authors: Bokov P, Essalhi M, Delclaux C

Abstract
Our objective was to assess whether obstructive sleep apnoea (OSA) patients were characterised by a reduced central CO2 controller gain (CG) and an enhanced plant gain (PG). We matched three groups of women (n=10 per group) enrolled in a previous study (Essalhi et al., J. Asthma. 50: 565-572, 2013): obese women with a respiratory disturbance index (RDI)?15/hour and with a RDI<15, and lean women without OSA (RDI<5). Tidal ventilation recordings during wakefulness with end-tidal PCO2 monitoring allowed the assessment of loop gain (LG) and its components (PG and CG). LG were similar for the three groups (p=0.844) while both PG and CG depicted significant differences (p=0.046 and p=0.011, respectively). Obese women with OSA were characterised by an increased PG and a reduced CG as compared to obese women without OSA. A negative relationship between CG and RDI (rho=-0.46, p=0.008) was evidenced. In conclusion, OSA in women is associated with a reduced central CO2 controller gain and an enhanced plant gain.

PMID: 26590323 [PubMed – as supplied by publisher]

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Nocturnal gastroesophageal reflux, asthma and symptoms of obstructive sleep apnoea: a longitudinal, general population study.

Eur Respir J. 2012 Sep 27;

Authors: Emilsson OI, Bengtsson A, Franklin KA, Torén K, Benediktsdóttir B, Farkhooy A, Weyler J, Dom S, Backer WD, Gislason T, Janson C

Abstract
Nocturnal gastroesophageal reflux (nGER) is associated with asthma and obstructive sleep apnoea (OSA). Our aim was to investigate whether nGER is a risk factor for onset of asthma and onset of respiratory and OSA symptoms in a prospective population based study.We invited 2640 subjects from Iceland, Sweden and Belgium for two evaluations over a nine years interval. They participated in structured interviews, answered questionnaires, underwent spirometries and methacholine challenge testing. nGER was defined by reported symptoms.Subjects with persistent nGER (n=123) had an independent increased risk of new asthma at follow-up [OR (95% CI): 2.3 (1.1-4.9)]. Persistent nGER was independently related to onset of respiratory symptoms [OR (95% CI): 3.0 (1.6-5.6)]. The risk of developing symptoms of OSA was increased in subjects with new and persistent nGER [OR (95% CI): 2.2 (1.3-1.6) and 2.0 (1.0-3.7), respectively]. No significant association was found between nGER and lung function or bronchial responsiveness.Persistent symptoms of nocturnal gastroesophageal reflux contributes to the development of asthma and respiratory symptoms. New onset of OSA symptoms is higher among subjects with symptoms of nGER. These findings support that nGER may play a role in the genesis of respiratory symptoms and diseases.

PMID: 23018910 [PubMed – as supplied by publisher]

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