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Philadelphia Magazine (blog) |
How Aspirin Can Make Your Asthma and Sinus Congestion Worse
Philadelphia Magazine (blog) Usually we can cite the common culprits for sinus congestion and asthma (pesky allergens and exercise come to mind), but aspirin can also exacerbate asthma and sinus congestion. And for those who suffer from this, aspirin allergy desensitization might … |
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Treatment of Aspirin Exacerbated Respiratory Disease with a Low Salicylate Diet: A Pilot Crossover Study.
Otolaryngol Head Neck Surg. 2014 Oct 24;
Authors: Sommer DD, Hoffbauer S, Au M, Sowerby LJ, Gupta MK, Nayan S
Abstract
OBJECTIVE: Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization.
STUDY DESIGN: A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS).
SETTING: The study was conducted in a tertiary otolaryngology clinic.
SUBJECTS: Patients with AERD were enrolled in the study.
METHODS: Subjective (Sino-nasal Outcome Test-22 [SNOT-22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire-7 [ACQ-7]) and objective outcome instruments (Peri-Operative Sinus Evaluation [POSE] and Lund-Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks.
RESULTS: Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT-22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005).
CONCLUSION: Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.
PMID: 25344589 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Condition: Aspirin Exacerbated Respiratory Disease (AERD)
Interventions: Drug: Ifetroban, Oral Capsule; Drug: Placebo, Oral Capsule
Sponsor: Cumberland Pharmaceuticals
Active, not recruiting – verified August 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
The Almagest |
Low dose aspirin protects against asthma
The Almagest There were 113 new cases of asthma in the aspirin group and 145 in the placebo group. Therefore, aspirin was associated with a 22 per cent reduction in risk of newly-diagnosed adult-onset asthma. However, the trial was actually designed to assess … |
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How popping aspirin can give you asthma for life – and why life-threatening …
Daily Mail However, while these patients are able to take other painkillers, some can be with left with lifelong asthma, triggered after their first allergic reaction. This is called aspirin-exacerbated respiratory disease, and affects about 10 per cent of the … |
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Asthma Plus Three Aspirin: Exacerbated Respiratory Disease
Pharmacy Times The Centers for Disease Control indicates that 8.2% of the US population has asthma, and up to 9% of adult asthmatics have this nonallergic hypersensitivity reaction. Patients experience 3 annoying and potentially life-threatening symptoms, dubbed the … |
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Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics.
Allergy Asthma Immunol Res. 2013 Jan;5(1):34-41
Authors: Kim JY, Kim JH, Park BL, Pasaje CF, Bae JS, Park JS, Jang AS, Uh ST, Kim YH, Kim MK, Choi IS, Cho SH, Choi BW, Park CS, Shin HD
Abstract
PURPOSE: Aspirin exacerbated respiratory disease (AERD) results in a severe asthma attack after aspirin ingestion in asthmatics. The filamin A interacting protein 1 (FILIP1) may play a crucial role in AERD pathogenesis by mediating T cell activation and membrane rearrangement. We investigated the association of FILIP1 variations with AERD and the fall rate of forced expiratory volume in one second (FEV1).
METHODS: A total of 34 common FILIP1 single nucleotide polymorphisms (SNPs) were genotyped in 592 Korean asthmatic subjects that included 163 AERD patients and 429 aspirin-tolerant asthma (ATA) controls.
RESULTS: This study found that 5 SNPs (P=0.006-0.01) and 2 haplotypes (P=0.01-0.03) of FILIP1 showed nominal signals; however, corrections for the multiple testing revealed no significant associations with the development of AERD (P(corr)>0.05). In addition, association analysis of the genetic variants with the fall rate of FEV1, an important diagnostic marker of AERD, revealed no significant evidence (P(corr)>0.05).
CONCLUSIONS: Although further replications and functional evaluations are needed, our preliminary findings suggest that genetic variants of FILIP1 might be not associated with the onset of AERD.
PMID: 23277876 [PubMed – in process]
View full post on pubmed: asthma