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Prostate Cancer News Today |
Study Finds Association Between Asthma And Lower Risk of Lethal Prostate Cancer
Prostate Cancer News Today Results from a recent large study conducted by Johns Hopkins researchers indicate that men with an asthma medical history are less prone to develop severe prostate cancer when compared to men who never suffered from the disease. The study, which was … |
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Xconomy |
FDA grants 501(k) clearance for platform used in association to treat asthma, COPD
Healio “501(k) clearance of our platform with inhaler devices from leading global respiratory companies GlaxoSmithKline and Boehringer Ingelheim opens the doors for millions of patients to expect and achieve something better in asthma and COPD,” David Van … FDA Clears 2 New Propeller Health Devices That Track Respiratory Meds Propeller Health Receives FDA Clearance For The Propeller Platform In … FDA Approves Propeller Health Mobile Platform for GlaxoSmithKline's Diskus DPI … |
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| Related Articles |
Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms.
Toxicol Appl Pharmacol. 2015 Jun 11;
Authors: Broström JM, Ye ZW, Axmon A, Littorin M, Tinnerberg H, Lindh CH, Zheng H, Ghalali A, Stenius U, Jönsson BA, Högberg J
Abstract
Diisocyanates are industrial chemicals which have a wide range of applications in developed and developing countries. They are notorious lung toxicants and respiratory sensitizers. However, the mechanisms behind their adverse effects are not adequately characterized. Autotaxin (ATX) is an enzyme producing lysophosphatidic acid (LPA), and the ATX-LPA axis has been implicated in lung related inflammatory conditions and diseases, including allergic asthma, but not to toxicity of environmental low-molecular-weight chemicals. We investigated effects of TDI on ATX induction in human lung epithelial cell models, and we correlated LPA-levels in plasma to biomarkers of toluene diisocyanate (TDI) exposure in urine collected from workers exposed to<5p.p.b.(parts per billion). Information on workers’ symptoms was collected through interviews. One nM TDI robustly induced ATX release within 10min in vitro. A P2X7- and P2X4-dependent microvesicle formation was implicated in a rapid ATX release and a subsequent protein synthesis. Co-localization between purinergic receptors and ATX was documented by immunofluorescence and confocal microscopy. The release was modulated by monocyte chemoattractant protein-1 (MCP-1) and by extracellular ATP. In workers, we found a dose-response relationship between TDI exposure biomarkers in urine and LPA levels in plasma. Among symptomatic workers reporting “sneezing”, the LPA levels were higher than among non-symptomatic workers. This is a first report indicating induction of the ATX-LPA axis by an environmental low-molecular-weight chemical, and our data suggest a role for the ATX-LPA axis in TDI toxicity.
PMID: 26072274 [PubMed – as supplied by publisher]
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American Osteopathic Association Notes Rise of Allergy-Triggered Asthma …
Business Wire (press release) CHICAGO–(BUSINESS WIRE)–Continually increasing pollen counts are causing more people to experience first-time allergy and asthma symptoms, signaling a need for physicians to educate patients about when to seek immediate medical attention, … |
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Lung Disease News |
Association Between Adverse Childhood Experiences and Pediatric Asthma …
Lung Disease News Results from a recent study conducted by a research team at the Hasbro Children's Hospital revealed an association between adverse childhood experiences and pediatric asthma. According to the study recently published in the Annals of Allergy, Asthma … Children exposed to adverse childhood experience more likely to develop asthma Gene may play part in how kids respond to asthma meds |
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St. Louis Public Radio |
American Lung Association wants to help St. Louis clinics improve asthma …
St. Louis Public Radio St. Louis area pediatricians will soon have help managing asthma care for their patients. The American Lung Association is implementing a program here to improve the system that primary care clinics use to identify and treat the disease. The Enhancing … |
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Nutrition and dietary intake and their association with mortality and hospitalisation in adults with chronic kidney disease treated with haemodialysis: protocol for DIET-HD, a prospective multinational cohort study.
BMJ Open. 2015;5(3):e006897
Authors: Palmer SC, Ruospo M, Campbell KL, Garcia Larsen V, Saglimbene V, Natale P, Gargano L, Craig JC, Johnson DW, Tonelli M, Knight J, Bednarek-Skublewska A, Celia E, Del Castillo D, Dulawa J, Ecder T, Fabricius E, Frazão JM, Gelfman R, Hoischen SH, Schön S, Stroumza P, Timofte D, Török M, Hegbrant J, Wollheim C, Frantzen L, Strippoli GF, DIET-HD Study investigators
Abstract
INTRODUCTION: Adults with end-stage kidney disease (ESKD) treated with haemodialysis experience mortality of between 15% and 20% each year. Effective interventions that improve health outcomes for long-term dialysis patients remain unproven. Novel and testable determinants of health in dialysis are needed. Nutrition and dietary patterns are potential factors influencing health in other health settings that warrant exploration in multinational studies in men and women treated with dialysis. We report the protocol of the “DIETary intake, death and hospitalisation in adults with end-stage kidney disease treated with HaemoDialysis (DIET-HD) study,” a multinational prospective cohort study. DIET-HD will describe associations of nutrition and dietary patterns with major health outcomes for adults treated with dialysis in several countries.
METHODS AND ANALYSIS: DIET-HD will recruit approximately 10?000 adults who have ESKD treated by clinics administered by a single dialysis provider in Argentina, France, Germany, Hungary, Italy, Poland, Portugal, Romania, Spain, Sweden and Turkey. Recruitment will take place between March 2014 and June 2015. The study has currently recruited 8000 participants who have completed baseline data. Nutritional intake and dietary patterns will be measured using the Global Allergy and Asthma European Network (GA(2)LEN) food frequency questionnaire. The primary dietary exposures will be n-3 and n-6 polyunsaturated fatty acid consumption. The primary outcome will be cardiovascular mortality and secondary outcomes will be all-cause mortality, infection-related mortality and hospitalisation.
ETHICS AND DISSEMINATION: The study is approved by the relevant Ethics Committees in participating countries. All participants will provide written informed consent and be free to withdraw their data at any time. The findings of the study will be disseminated through peer-reviewed journals, conference presentations and to participants via regular newsletters. We expect that the DIET-HD study will inform large pragmatic trials of nutrition or dietary interventions in the setting of advanced kidney disease.
PMID: 25795691 [PubMed – as supplied by publisher]
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American Lung Association recruiting children for asthma camp
Hampshire Review Celebrating its 25th anniversary, Camp Catch Your Breath is specifically for children between the ages of 8 and 13 who have asthma. According to Sonny Hoskinson, camp director (UHC), Camp Catch Your Breath combines traditional summer camp activities … |
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The Treatment of Asthma: Portion of a Lecture delivered in the Regular Course …
JAMA: The Journal of the American Medical Association For the relief of asthma an almost countless number of drugs have been suggested and tried. It is not my purpose even to enumerate these, but to call attention to those that are to day most frequently employed with success and to those with which I … |
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Related Articles |
The association between asthma and rhinitis is stable over time despite diverging trends in prevalence.
Respir Med. 2015 Jan 21;
Authors: Bjerg A, Eriksson J, Ólafsdóttir IS, Middelveld R, Franklin K, Forsberg B, Larsson K, Torén K, Dahlén SE, Janson C
Abstract
BACKGROUND: Despite the well-known association between asthma and rhinitis, in Swedish adults the prevalence of rhinitis rose from 22% to 31% between 1990 and 2008 while asthma prevalence was unchanged. We tested whether the association of rhinitis with asthma was stable over time using the same population-based databases.
METHODS: Two surveys of adults (20-44 years) living in three regions of Sweden, carried out in 1990 (n = 8982) and 2008 (n = 9156) were compared. Identical questions regarding respiratory symptoms, asthma and rhinitis were used. Asthmatic wheeze: Wheeze with breathlessness apart from colds. Current asthma: Asthma attacks and/or asthma medication use.
RESULTS: Subjects with rhinitis had level time trends in asthmatic wheeze, current asthma and most nocturnal respiratory symptoms between 1990 and 2008, adjusted for age, sex, area and smoking. Any wheeze however decreased slightly. In never-smokers asthma symptoms were similarly associated with rhinitis in 1990 and 2008: any wheeze OR 4.0 vs. 4.4 (p = 0.339); asthmatic wheeze OR 6.0 vs. 5.9 (p = 0.937); and current asthma OR 9.6 vs. 7.7 (p = 0.213). In the whole population there were decreases in the asthma symptoms most closely associated to smoking, which decreased by half 1990-2008. Conversely current asthma, which was strongly associated with rhinitis and not with smoking, increased (p < 0.001).
CONCLUSIONS: The association of rhinitis with asthma was stable between 1990 and 2008. The pattern in the time trends of asthma outcomes strongly suggests that decreased smoking counterbalanced the driving effect of increased rhinitis on asthma prevalence. The findings illustrate the public health benefits of decreased smoking.
PMID: 25638411 [PubMed – as supplied by publisher]
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