American Lung Association in New Jersey Helps Students with Asthma Return to … – Atlantic Highlands Herald

American Lung Association in New Jersey Helps Students with Asthma Return to
Atlantic Highlands Herald
BRIDGEWATER, NJ –As summer winds down, families across New Jersey are beginning to prepare for the new school year. A new school environment can sometimes be difficult for children with asthma. This back-to-school season, the American Lung 

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American Lung Association Envisions Drug-Free Asthma Treatment in the Near … – HealthNewsDigest.com

American Lung Association Envisions Drug-Free Asthma Treatment in the Near
HealthNewsDigest.com
(HealthNewsDigest.com) – The American Lung Association Asthma Clinical Research Centers (ACRC) is the largest not-for-profit network of clinical research centers dedicated to discovering effective treatment strategies for asthma. The network is

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Meta-analysis of the Association Between Secondhand Smoke Exposure and Physician-Diagnosed Childhood Asthma.

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Meta-analysis of the Association Between Secondhand Smoke Exposure and Physician-Diagnosed Childhood Asthma.

Nicotine Tob Res. 2013 Mar 28;

Authors: Tinuoye O, Pell JP, Mackay DF

Abstract
INTRODUCTION: Studies suggest an association between secondhand smoke exposure and the development of childhood asthma. Several countries are considering legislation to protect children from exposure. METHODS: A systematic review was conducted using MEDLINE, Embase, PubMed, and Web of Knowledge databases and a random effects meta-analysis was undertaken. Heterogeneity was assessed using the I(2) test. Publication and small study biases were examined visually using a funnel plot and tested formally using Egger test. Univariate and multivariate meta-regression analyses were undertaken, including a subgroup analysis of cohort studies to examine the effect of duration of follow-up. RESULTS: Twenty relevant studies were identified (14 cross-sectional, 4 cohort, and 2 case-control) and provided 31 estimates of effect size. The pooled odds ratio was 1.32 (95% CI: 1.23, 1.42, p < .001). There was moderate heterogeneity (I(2) = 74.2%, p < .001). On multivariate meta-regression analysis, effect size estimates were significantly higher for case-control studies (p = .042) and those using self-reported exposure to secondhand smoke (p = .050). There was no evidence of significant publication or small study bias (Egger test, p = .121). CONCLUSIONS: There is now consistent evidence of a modest association between secondhand smoke and physician-diagnosed childhood asthma. These results lend support to continued efforts to reduce childhood exposure to secondhand smoke.

PMID: 23539174 [PubMed – as supplied by publisher]

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The association between asthma control, health care costs, and quality of life … – 7thSpace Interactive (press release)

The association between asthma control, health care costs, and quality of life
7thSpace Interactive (press release)
Methods: An observational cost of illness study was conducted simultaneously in both countries among patients age greater or equal to 18 with a diagnosis of asthma for at least 12 months. Patients were recruited prospectively by GPs in 2010 in four

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Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics.

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Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics.

Allergy Asthma Immunol Res. 2013 Jan;5(1):34-41

Authors: Kim JY, Kim JH, Park BL, Pasaje CF, Bae JS, Park JS, Jang AS, Uh ST, Kim YH, Kim MK, Choi IS, Cho SH, Choi BW, Park CS, Shin HD

Abstract
PURPOSE: Aspirin exacerbated respiratory disease (AERD) results in a severe asthma attack after aspirin ingestion in asthmatics. The filamin A interacting protein 1 (FILIP1) may play a crucial role in AERD pathogenesis by mediating T cell activation and membrane rearrangement. We investigated the association of FILIP1 variations with AERD and the fall rate of forced expiratory volume in one second (FEV1).
METHODS: A total of 34 common FILIP1 single nucleotide polymorphisms (SNPs) were genotyped in 592 Korean asthmatic subjects that included 163 AERD patients and 429 aspirin-tolerant asthma (ATA) controls.
RESULTS: This study found that 5 SNPs (P=0.006-0.01) and 2 haplotypes (P=0.01-0.03) of FILIP1 showed nominal signals; however, corrections for the multiple testing revealed no significant associations with the development of AERD (P(corr)>0.05). In addition, association analysis of the genetic variants with the fall rate of FEV1, an important diagnostic marker of AERD, revealed no significant evidence (P(corr)>0.05).
CONCLUSIONS: Although further replications and functional evaluations are needed, our preliminary findings suggest that genetic variants of FILIP1 might be not associated with the onset of AERD.

PMID: 23277876 [PubMed – in process]

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Asthma Coalition of Long Island Joins Lung Association; Offers Health Advice – Long Island Exchange

Asthma Coalition of Long Island Joins Lung Association; Offers Health Advice
Long Island Exchange
(Hauppauge, N.Y.) – As the cleanup from Hurricane Sandy continues, the Asthma Coalition of Long Island and the American Lung Association of the Northeast are reminding residents of affected areas on Long Island New York to keep their lung health in

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