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Ajanta Pharma gets USFDA nod for generic asthma treatment drug
Economic Times NEW DELHI: Drug firm Ajanta Pharma has received final approvals from the US health regulator for generic montelukast tablets and oral granules used for prevention and treatment of asthma and to relieve symptoms of seasonal hay fever. The company has … |
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Expression of adenosine receptors in monocytes from patients with bronchial asthma.
Biochem Biophys Res Commun. 2015 Jul 29;
Authors: Yuryeva K, Saltykova I, Ogorodova L, Kirillova N, Kulikov E, Korotkaya E, Iakovleva Y, Feoktistov I, Sazonov A, Ryzhov S
Abstract
Adenosine is generated from adenosine triphosphate, which is released by stressed and damaged cells. Adenosine levels are significantly increased in patients with bronchial asthma (BA) and mediate mast cell degranulation and bronchoconstriction. Over the last decade, increasing evidence has shown that adenosine can modulate the innate immune response during monocytes differentiation towards mature myeloid cells. These adenosine-differentiated myeloid cells, characterized by co-expression of monocytes/macrophages and dendritic cell markers such as CD14 and CD209, produce high levels of pro-inflammatory cytokines, thus contributing to the pathogenesis of BA and chronic obstructive pulmonary disease. We found that expression of ADORA2A and ADORA2B are increased in monocytes obtained from patients with BA, and are associated with the generation of CD14(pos)CD209(pos) pro-inflammatory cells. A positive correlation between expression of ADORA2B and IL-6 was identified in human monocytes and may explain the increased expression of IL-6 mRNA in asthmatics. Taken together, our results suggest that monocyte-specific expression of A2 adenosine receptors plays an important role in pro-inflammatory activation of human monocytes, thus contributing to the progression of asthma.
PMID: 26232643 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Condition: Asthma
Intervention: Drug: MEDI9929 (AMG 157)
Sponsors: MedImmune LLC; Amgen
Not yet recruiting – verified July 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Allergy & Asthma Network Applauds Clean Power Plan
PR Newswire (press release) VIENNA, Va., Aug. 3, 2015 /PRNewswire-USNewswire/ — Allergy & Asthma Network, the leading nonprofit patient education and advocacy organization, announced its strong support for the Clean Power Plan, a new initiative that will help combat climate … A smarter way to track your asthma symptoms |
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Daily Mail |
Paper cup that helps beat asthma attacks could replace spacers
Daily Mail A disposable cup similar to those used to serve takeaway hot drinks could transform the way in which asthma attacks are treated. The paper cup is designed to replace spacers – the large plastic cylinders used to make sure that patients inhale the right … |
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The Wiire (blog) |
New Lab-on-a-Chip to identify Asthma as well as Tuberculosis
The Wiire (blog) The researchers have developed a low cost chip on device that can analyze sputum from patients with pulmonary diseases such as tuberculosis and asthma. This is an accurate diagnosis that would help a lot of people in the long run. The sample cells are … Lab on a Chip Acoustofluidic Sputum Liquefaction Device for Safe Asthma and … New Lab-on-a-Chip to Better Diagnose Asthma, Tuberculosis On-Chip Processor the First Step in Point-of-Care Tuberculosis and Asthma … |
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Lung Disease News |
On-Chip Processor An Advance in Point-of-Care Asthma and Tuberculosis Diagnostics
Lung Disease News Asthma pathogenesis of involves airway inflammation, airway remodeling, and hyperreactivity, which lead to difficulty in breathing that can be deadly if not properly controlled. Steroid medications can successfully treat asthma in most cases, but side … Lab on a Chip Acoustofluidic Sputum Liquefaction Device for Safe Asthma and … New Lab-on-a-Chip to identify Asthma as well as Tuberculosis On-Chip Processor the First Step in Point-of-Care Tuberculosis and Asthma … |
View full post on asthma – Google News
AZoNano.com |
Lab on a Chip Acoustofluidic Sputum Liquefaction Device for Safe Asthma and …
AZoNano.com Stewart J. Levine, a Senior Investigator and Chief of the Laboratory of Asthma and Lung Inflammation in the Division of Intramural Research at NHLBI, said “This on-chip sputum liquefier is a significant advance regarding our goal of developing a point … New Lab-on-a-Chip to Better Diagnose Asthma, Tuberculosis Lab-on-a-chip device to better diagnose asthma, TB |
View full post on asthma – Google News
NDTV |
New Lab-on-a-Chip to Better Diagnose Asthma, Tuberculosis
NDTV Researchers have developed a low-cost lab-on-a-chip device to analyse sputum from patients with pulmonary diseases such as tuberculosis and asthma. "To develop more accurate diagnosis and treatment approaches for patients with pulmonary diseases, … Lab-on-a-chip device to better diagnose asthma, TB |
View full post on asthma – Google News
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The Influence of Setting on Care Coordination for Childhood Asthma.
Health Promot Pract. 2015 Jul 31;
Authors: Kelly RP, Stoll SC, Bryant-Stephens T, Janevic MR, Lara M, Ohadike YU, Persky V, Ramos-Valencia G, Uyeda K, Malveaux FJ
Abstract
Asthma affects 7.1 million children in the United States, disproportionately burdening African American and Latino children. Barriers to asthma control include insufficient patient education and fragmented care. Care coordination represents a compelling approach to improve quality of care and address disparities in asthma. The sites of The Merck Childhood Asthma Network Care Coordination Programs implemented different models of care coordination to suit specific settings-school district, clinic or health care system, and community-and organizational structures. A variety of qualitative data sources were analyzed to determine the role setting played in the manifestation of care coordination at each site. There were inherent strengths and challenges of implementing care coordination in each of the settings, and each site used unique strategies to deliver their programs. The relationship between the lead implementing unit and entities that provided (1) access to the priority population and (2) clinical services to program participants played a critical role in the structure of the programs. The level of support and infrastructure provided by these entities to the lead implementing unit influenced how participants were identified and how asthma care coordinators were integrated into the clinical care team.
PMID: 26232778 [PubMed – as supplied by publisher]
View full post on pubmed: asthma