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Azithromycin shortens symptom duration for pediatric patients with asthma-like …
Healio Stokholm and colleagues evaluated 72 children aged between 1 year and 3 years from the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort who randomly received either azithromycin or placebo during an asthma-like episode, … |
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Horsetalk |
Viral clue found to asthma-like condition in horses
Horsetalk Melissa Mazan and her colleagues, writing in the journal, Multidisciplinary Respiratory Medicine, noted that human rhinovirus was an important trigger for the development of asthma in humans. However, a similar role for respiratory viruses in horses … |
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Delmarva Daily Times |
School Wing Cleared After Three Students Report Asthma-like Symptoms
WBOC TV 16 SALISBURY, Md.- Officials say a classroom wing at Pemberton Elementary School in Salisbury was cleared Wednesday afternoon after three kindergarten students who experienced asthma-like symptoms were taken for a medical evaluation. Tracy Sahler, a … 3 kindergarten students experience "asthma-like" symptoms Pemberton Elementary cleared after students' illnesses |
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School Wing Cleared After Three Students Report Asthma-like Symp – WBOC-TV …
WBOC TV 16 SALISBURY, Md.- Officials say a classroom wing at Pemberton Elementary School in Salisbury was cleared Wednesday afternoon after three kindergarten students who experienced asthma-like symptoms were taken for a medical evaluation. Tracy Sahler, a … |
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Virus With Asthma-Like Symptoms Spreading in Colorado
KRDO Virus With Asthma-Like Symptoms Spreading in Colorado. POSTED: 06:00 PM MDT Sep 06, 2014 UPDATED: 01:32 AM MDT Sep 07, 2014. Small Text; Medium Text; Large Text. Print; Email. Tweet. Virus has sickened nearly 1,000 in Denver area and has … |
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Influence of farming exposure on the development of asthma and asthma-like symptoms.
Int Immunopharmacol. 2014 Jul 30;
Authors: Wells AD, Poole JA, Romberger DJ
Abstract
Based upon age and type of farming exposures, a wide range of studies demonstrate either protective or deleterious effects of the farming environment on asthma. In this review, we highlight key studies supporting the concept that farming exposure protects children from asthma and atopy based on studies performed largely in European pediatric cohorts. Various types of farming in certain regions appear to have a greater effect on asthma protection, as does the consumption of unpasteurized milk. In the United State, where concentrated animal feeding operations (CAFOs) are more common, asthma is increased in children exposed especially to swine CAFOs; whereas, rates of atopy and allergy are lower in these children. We also review studies evaluating the role of farming exposures both as a child and/or as an adult on asthma seen in adults. The importance of microbes in farming environments and the contribution of various components of the innate immune system including toll-like receptors to the underlying mechanisms of asthma related to farming exposures are also reviewed.
PMID: 25086344 [PubMed – as supplied by publisher]
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Mycoplasma pneumoniae CARDS Toxin Exacerbates Ovalbumin-Induced Asthma-Like Inflammation in BALB/c Mice.
PLoS One. 2014;9(7):e102613
Authors: Medina JL, Coalson JJ, Brooks EG, Le Saux CJ, Winter VT, Chaparro A, Principe MF, Solis L, Kannan TR, Baseman JB, Dube PH
Abstract
Mycoplasma pneumoniae causes a range of airway and extrapulmonary pathologies in humans. Clinically, M. pneumoniae is associated with acute exacerbations of human asthma and a worsening of experimentally induced asthma in mice. Recently, we demonstrated that Community Acquired Respiratory Distress Syndrome (CARDS) toxin, an ADP-ribosylating and vacuolating toxin synthesized by M. pneumoniae, is sufficient to induce an asthma-like disease in BALB/cJ mice. To test the potential of CARDS toxin to exacerbate preexisting asthma, we examined inflammatory responses to recombinant CARDS toxin in an ovalbumin (OVA) murine model of asthma. Differences in pulmonary inflammatory responses between treatment groups were analyzed by histology, cell differentials and changes in cytokine and chemokine concentrations. Additionally, assessments of airway hyperreactivity were evaluated through direct pulmonary function measurements. Analysis of histology revealed exaggerated cellular inflammation with a strong eosinophilic component in the CARDS toxin-treated group. Heightened T-helper type-2 inflammatory responses were evidenced by increased expression of IL-4, IL-13, CCL17 and CCL22 corresponding with increased airway hyperreactivity in the CARDS toxin-treated mice. These data demonstrate that CARDS toxin can be a causal factor in the worsening of experimental allergic asthma, highlighting the potential importance of CARDS toxin in the etiology and exacerbation of human asthma.
PMID: 25058417 [PubMed – in process]
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Healthy Oshkosh: Exercise still possible despite asthma-like symptoms
The Oshkosh Northwestern Healthy Oshkosh: Exercise-induced asthma: This week's topic is exercise-induced asthma. Healthy Oshkosh is a community partnership with the Oshkosh YMCA produced by Oshkosh Northwestern Media and examines some of the topics that keep Oshkosh … |
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 Horsetalk |
Discovery holds promise for horses with asthma-like condition
Horsetalk A discovery by Canadian researchers will help in understanding how horses develop recurrent airway obstruction (RAO) and offers hope of potential solutions for people with asthma. In a paper in a recent issue of BMC Genomics, the researchers from the … |
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After Adolescence, Asthma-like Symptoms May Not Be Asthma
San Leandro Times Most of us recognize episodes of wheezing, coughing and difficulty breathing as bronchial asthma, a long-term disease of the lungs affecting more than 24 million US adults and children. When these symptoms begin in adulthood, … |
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