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Malibu Search team rescues asthmatic hiker
Malibu Times 'Tree House' rescue in Malibu canyon. An 18-year-old woman suffering an asthma attack was rescued from a canyon in Malibu near Kanan Dume Road and Mulholland Highway on Thursday evening. 'Tree House' rescue in Malibu. Roger LeBrun, Malibu … |
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Study finds up to 75 percent of asthmatic adults have an allergy
Fox News However, a new study published in this month's Annals of Allergy, Asthma and Immunology found that about 75 percent of asthma sufferers aged 20 to 40 years old and 65 percent of asthmatic adults aged 55 years and older, have at least one confirmed … Have asthma? You likely have an allergy as well Asthma and Allergies Go Hand In Hand Asthma and Allergy Foundation: Most Allergic Cities in U.S. |
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Pamela Tapia: My life as an asthmatic
Willits News When I came to Oakland from Mexico in 7th grade, language was not my greatest challenge. My immigration status was not a barrier either. Asthma was my nemesis. My first attack was on my way to McClymonds High School, when I was a shy sophomore … |
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Diffusion lung capacity of carbon monoxide: A novel marker of airways remodeling in asthmatic children?
Allergy Rhinol (Providence). 2012;3(2):e66-73
Authors: Piacentini GL, Tezza G, Cattazzo E, Kantar A, Ragazzo V, Boner AL, Peroni DG
Abstract
Asthma is universally considered a chronic inflammatory disorder of the airways. Several noninvasive markers, such as exhaled nitric oxide (FeNO) and exhaled breath temperature (PletM), have been proposed to evaluate the degree of airway inflammation and remodeling in asthmatic children. The aim of this study was to evaluate the relationship between diffusion lung capacity of carbon monoxide (DLCO) and these inflammatory markers in asthmatic children. We compared data of FeNO, PletM, and DLCO collected in 35 asthmatic children at admission (T0) and discharge (T1) after a period spent in a dust-mite-free environment (Misurina, Italian Dolomites, 1756 m). PletM showed a reduction from 29.48°C at T0 to 29.13°C at T1 (p = 0.17); DLCO passed from 93 to 102 (p = 0.085). FeNO mean value was 29.7 ppb at admission and 18.9 ppb at discharge (p = 0.014). Eosinophil mean count in induced sputum was 4 at T0 and 2 at T1 (p = 0.004). Spearman standardization coefficient beta was 0.414 between eosinophils and FeNO and -0.278 between eosinophils and DLCO. Pearson’s correlation index between DLCO and PletM was -0.456 (p = 0.019). A negative correlation between DLCO and PletM was found. However, DLCO did not show a significant correlation with FeNO and eosinophils in the airways. Additional studies are needed to clarify the role of DLCO as a potential tool in monitoring childhood asthma.
PMID: 23342292 [PubMed – in process]
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Urban lifestyle leading to rise in asthmatic children: World Allergy Organisation
Times of India HYDERABAD: Asthma in children is increasing alarmingly in India with at least 15% rise mainly in big metros in thelast 10 years,the WorldAllergy Organisation (WAO ) said. With global warming, increase in pollution and change in lifestyle, the number of … |
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Mum says council house is so cold it makes asthmatic son ill
Reading Post A YOUNG mum says her cold and draughty home is making her asthmatic son ill, and neither of them can cope with the stairs. Charlene Maze, 23, says after her complaints to Reading Borough Council she has had 'about 30' visits from surveyors, but only … |
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Altered CD38/Cyclic ADP-Ribose Signaling Contributes to the Asthmatic Phenotype.
J Allergy (Cairo). 2012;2012:289468
Authors: Jude JA, Dileepan M, Panettieri RA, Walseth TF, Kannan MS
Abstract
CD38 is a transmembrane glycoprotein expressed in airway smooth muscle cells. The enzymatic activity of CD38 generates cyclic ADP-ribose from ?-NAD. Cyclic ADP-ribose mobilizes intracellular calcium during activation of airway smooth muscle cells by G-protein-coupled receptors through activation of ryanodine receptor channels in the sarcoplasmic reticulum. Inflammatory cytokines that are implicated in asthma upregulate CD38 expression and increase the calcium responses to contractile agonists in airway smooth muscle cells. The augmented intracellular calcium responses following cytokine exposure of airway smooth muscle cells are inhibited by an antagonist of cyclic ADP-ribose. Airway smooth muscle cells from CD38 knockout mice exhibit attenuated intracellular calcium responses to agonists, and these mice have reduced airway response to inhaled methacholine. CD38 also contributes to airway hyperresponsiveness as shown in mouse models of allergen or cytokine-induced inflammatory airway disease. In airway smooth muscle cells obtained from asthmatics, the cytokine-induced CD38 expression is significantly enhanced compared to expression in cells from nonasthmatics. This differential induction of CD38 expression in asthmatic airway smooth muscle cells stems from increased activation of MAP kinases and transcription through NF-?B, and altered post-transcriptional regulation through microRNAs. We propose that increased capacity for CD38 signaling in airway smooth muscle in asthma contributes to airway hyperresponsiveness.
PMID: 23213344 [PubMed – in process]
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Safety and efficacy of the prostaglandin D(2) receptor antagonist AMG 853 in asthmatic patients.
J Allergy Clin Immunol. 2012 Nov 19;
Authors: Busse WW, Wenzel SE, Meltzer EO, Kerwin EM, Liu MC, Zhang N, Chon Y, Budelsky AL, Lin J, Lin SL
Abstract
BACKGROUND: The D-prostanoid receptor and the chemoattractant receptor homologous molecule expressed on T(H)2 cells (CRTH2) are implicated in asthma pathogenesis. AMG 853 is a potent, selective, orally bioavailable, small-molecule dual antagonist of human D-prostanoid and CRTH2. OBJECTIVE: We sought to determine the efficacy and safety of AMG 853 compared with placebo in patients with inadequately controlled asthma. METHODS: Adults with moderate-to-severe asthma were randomized to placebo; 5, 25, or 100 mg of oral AMG 853 twice daily; or 200 mg of AMG 853 once daily for 12 weeks. All patients continued their inhaled corticosteroids. Long-acting ?-agonists were not allowed during the treatment period. Allowed concomitant medications included short-acting ?-agonists and a systemic corticosteroid burst for asthma exacerbation. The primary end point was change in total Asthma Control Questionnaire score from baseline to week 12. Secondary and exploratory end points included FEV(1), symptom scores, rescue short-acting ?-agonist use, and exacerbations. RESULTS: Among treated patients, no effect over placebo (n = 79) was observed in mean changes in Asthma Control Questionnaire scores at 12 weeks (placebo, -0.492; range for AMG 853 groups [n = 317], -0.444 to -0.555). No significant differences between the active and placebo groups were observed for secondary end points. The most commonly reported adverse events were asthma, upper respiratory tract infection, and headache; 9 patients experienced serious adverse events, all of which were deemed unrelated to study treatment by the investigator. CONCLUSION: AMG 853 as an add-on to inhaled corticosteroid therapy demonstrated no associated risks but was not effective at improving asthma symptoms or lung function in patients with inadequately controlled moderate-to-severe asthma.
PMID: 23174659 [PubMed – as supplied by publisher]
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Asthmatic children may suffer more from dirty hands – chicagotribune.com
Chicago Tribune NEW YORK (Reuters Health) – An arsenal of hand sanitizers, hygiene education and good old-fashioned soap failed to prevent asthma attacks among school children in one Alabama county. For children with asthma, the common cold is the top trigger of … |
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Upper Marlboro Asthmatic Runs First Marathon
Patch.com Following a serious asthma attack in her 20s, she has worked with a doctor to help control her symptons and now after training for weeks she'll run the Marine Corps Marathon Sunday. She'll be one of the 28 runners from eight states representing the … |
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