Breathe Well Live Well
Condition: Asthma
Interventions: Drug: Symbicort; Drug: Generic Budesonide/Formoterol fumarate dihydrate; Drug: Placebo
Sponsor: Actavis Inc.
Not yet recruiting – verified July 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Asthma
Intervention: Other: Q-Kap
Sponsor: Stefania La Grutta, MD
Not yet recruiting – verified June 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
The Exponent Telegram (press release) (registration) |
Camp for asthmatic children celebrates 25 years
The Exponent Telegram (press release) (registration) BRIDGEPORT — Over a thousand children across the state of West Virginia suffer from asthma, according to Patricia Fast, vice president government programs and operations for the non-profit organization the Health Plan. For the last 25 years the Health … |
View full post on asthma – Google News
Condition: Asthma
Interventions: Behavioral: 2: Intervention; Behavioral: 1: Control
Sponsor: Assistance Publique – Hôpitaux de Paris
Not yet recruiting – verified April 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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In-home intervention program helps keep asthmatic children out of Fresno …
Fresno Bee It's Pineda's job to walk through homes of asthmatic children in Fresno County looking for dust and other lung irritants and recommend ways to eliminate or reduce them. The children are enrolled in Asthma Impact Model for Fresno, a two-year pilot … |
View full post on asthma – Google News
Condition: Asthma
Interventions: Drug: omalizumab; Biological: Rhinovirus (strain 16)
Sponsors: University of Virginia; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting – verified March 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Airway Lumen is Reduced in Asthmatic Smokers, According to Study
Lung Disease News According to a recent study published in the journal Chest, the Official Journal of the American College of Chest Physicians found that compared to people with asthma who never smoked, the CT scan segmental airway lumen area is reduced in those with … |
View full post on asthma – Google News
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Obesity associated with bronchodilator unresponsiveness in asthmatic minority …
Healio The researchers conducted a cross-sectional study using data from the Study of African Americans, Asthma, Genes & Environment (n = 867) and the Genes-Environments & Admixture in Latino Americans (GALA II; n = 2, 096). Thirty-six percent of the cohort … |
View full post on asthma – Google News
Condition: Asthma
Interventions: Drug: Vapendavir; Drug: Vapendavir; Drug: Placebo
Sponsor: Biota Pharmaceuticals, Inc.
Recruiting – verified February 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
| Related Articles |
Undifferentiated Bronchial Fibroblasts Derived from Asthmatic Patients Display Higher Elastic Modulus than Their Non-Asthmatic Counterparts.
PLoS One. 2015;10(2):e0116840
Authors: Sarna M, Wojcik KA, Hermanowicz P, Wnuk D, Burda K, Sanak M, Czy? J, Michalik M
Abstract
During asthma development, differentiation of epithelial cells and fibroblasts towards the contractile phenotype is associated with bronchial wall remodeling and airway constriction. Pathological fibroblast-to-myofibroblast transition (FMT) can be triggered by local inflammation of bronchial walls. Recently, we have demonstrated that human bronchial fibroblasts (HBFs) derived from asthmatic patients display some inherent features which facilitate their FMT in vitro. In spite of intensive research efforts, these properties remain unknown. Importantly, the role of undifferentiated HBFs in the asthmatic process was systematically omitted. Specifically, biomechanical properties of undifferentiated HBFs have not been considered in either FMT or airway remodeling in vivo. Here, we combine atomic force spectroscopy with fluorescence microscopy to compare mechanical properties and actin cytoskeleton architecture of HBFs derived from asthmatic patients and non-asthmatic donors. Our results demonstrate that asthmatic HBFs form thick and aligned ‘ventral’ stress fibers accompanied by enlarged focal adhesions. The differences in cytoskeleton architecture between asthmatic and non-asthmatic cells correlate with higher elastic modulus of asthmatic HBFs and their increased predilection to TGF-?-induced FMT. Due to the obvious links between cytoskeleton architecture and mechanical equilibrium, our observations indicate that HBFs derived from asthmatic bronchi can develop considerably higher static tension than non-asthmatic HBFs. This previously unexplored property of asthmatic HBFs may be potentially important for their myofibroblastic differentiation and bronchial wall remodeling during asthma development.
PMID: 25679502 [PubMed – as supplied by publisher]
View full post on pubmed: asthma