Breathe Well Live Well
| Related Articles |
Treatment of asthma: predicting the future of atopic disease treatment Dr. Paul O’Byrne in an interview with Dr. Roman Jaeschke: part 2.
Pol Arch Med Wewn. 2016 Dec 23;126(12):1031-1032
Authors: O’Byrne P, Jaeschke R
PMID: 28010009 [PubMed – in process]
View full post on pubmed: asthma
| Related Articles |
Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies.
Front Pharmacol. 2016;7:299
Authors: Thompson MD, Capra V, Clunes MT, Rovati GE, Stankova J, Maj MC, Duffy DL
Abstract
Genetic variants associated with asthma pathogenesis and altered response to drug therapy are discussed. Many studies implicate polymorphisms in genes encoding the enzymes responsible for leukotriene synthesis and intracellular signaling through activation of seven transmembrane domain receptors, such as the cysteinyl leukotriene 1 (CYSLTR1) and 2 (CYSLTR2) receptors. The leukotrienes are polyunsaturated lipoxygenated eicosatetraenoic acids that exhibit a wide range of pharmacological and physiological actions. Of the three enzymes involved in the formation of the leukotrienes, arachidonate 5 lipoxygenase 5 (ALOX5), leukotriene C4 synthase (LTC4S), and leukotriene hydrolase (LTA4H) are all polymorphic. These polymorphisms often result in variable production of the CysLTs (LTC4, LTD4, and LTE4) and LTB4. Variable number tandem repeat sequences located in the Sp1-binding motif within the promotor region of the ALOX5 gene are associated with leukotriene burden and bronchoconstriction independent of asthma risk. A 444A > C SNP polymorphism in the LTC4S gene, encoding an enzyme required for the formation of a glutathione adduct at the C-6 position of the arachidonic acid backbone, is associated with severe asthma and altered response to the CYSLTR1 receptor antagonist zafirlukast. Genetic variability in the CysLT pathway may contribute additively or synergistically to altered drug responses. The 601 A > G variant of the CYSLTR2 gene, encoding the Met201Val CYSLTR2 receptor variant, is associated with atopic asthma in the general European population, where it is present at a frequency of ?2.6%. The variant was originally found in the founder population of Tristan da Cunha, a remote island in the South Atlantic, in which the prevalence of atopy is approximately 45% and the prevalence of asthma is 36%. In vitro work showed that the atopy-associated Met201Val variant was inactivating with respect to ligand binding, Ca(2+) flux and inositol phosphate generation. In addition, the CYSLTR1 gene, located at Xq13-21.1, has been associated with atopic asthma. The activating Gly300Ser CYSLTR1 variant is discussed. In addition to genetic loci, risk for asthma may be influenced by environmental factors such as smoking. The contribution of CysLT pathway gene sequence variants to atopic asthma is discussed in the context of other genes and environmental influences known to influence asthma.
PMID: 27990118 [PubMed – in process]
View full post on pubmed: asthma
Condition: Asthma
Interventions: Biological: Benralizumab; Other: Placebo
Sponsor: AstraZeneca
Not yet recruiting – verified June 2016
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
| Related Articles |
Associations of Physical Activity and Sedentary Behavior with Atopic Disease in United States Children.
J Pediatr. 2016 May 4;
Authors: Strom MA, Silverberg JI
Abstract
OBJECTIVES: To determine if eczema, asthma, and hay fever are associated with vigorous physical activity, television/video game usage, and sports participation and if sleep disturbance modifies such associations.
STUDY DESIGN: Data were analyzed from 2 cross-sectional studies including 133?107 children age 6-17 years enrolled in the 2003-2004 and 2007-2008 National Survey of Children’s Health. Bivariate and multivariate survey logistic regression models were created to calculate the odds of atopic disease and atopic disease severity on vigorous physical activity, television/video game use, and sports participation.
RESULTS: In multivariate logistic regression models controlling for sociodemographic factors, lifetime history of asthma was associated with decreased odds of ?1 days of vigorous physical activity (aOR, 0.87; 95% CI, 0.77-0.99) and decreased odds of sports participation (0.91; 95% CI, 0.84-0.99). Atopic disease accompanied by sleep disturbance had significantly higher odds of screen time and lower odds of sports participation compared with children with either atopic disease or sleep disturbance alone. Severe eczema (aOR, 0.39; 95% CI, 0.19-0.78), asthma (aOR, 0.29; 95% CI, 0.14-0.61), and hay fever (aOR, 0.48; 95% CI, 0.24-0.97) were all associated with decreased odds of ?1 days of vigorous physical activity. Moderate (aOR, 0.76; 95% CI, 0.57-0.99) and severe eczema (aOR, 0.45; 95% CI, 0.28-0.73), severe asthma (aOR, 0.47; 95% CI, 0.25-0.89), and hay fever (aOR, 0.53; 95% CI, 0.36-0.61) were associated with decreased odds of sports participation in the past year.
CONCLUSIONS: Children with severe atopic disease, accompanied by sleep disturbance, have higher risk of sedentary behaviors.
PMID: 27156181 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
| Related Articles |
Association between Dietary Patterns and Atopic Dermatitis in Relation to GSTM1 and GSTT1 Polymorphisms in Young Children.
Nutrients. 2015;7(11):9440-9452
Authors: Chung J, Kwon SO, Ahn H, Hwang H, Hong SJ, Oh SY
Abstract
Previous research suggests the association of glutathione S-transferase (GST) gene polymorphisms or diet, but no interactions between these factors in atopic dermatitis (AD). We conducted a community-based case-control study including 194 AD and 244 matched non-AD preschoolers. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) present/null genotypes were evaluated uisng a multiplex PCR method. We measured dietary intakes by a validated food frequency questionnaire and constructed three dietary patterns such as “traditional healthy”, “animal foods”, and “sweets” diets. In stratified analyses by GST genotypes, the “traditional healthy” diet and reduced AD showed association only in the GSTM1-present group (odd ratio (OR) 0.31, 95% confidence interval (CI) 0.13-0.75). A similar pattern of the association existed in the combined GSTM1/T1 genotype that indicated the inverse association between the “traditional healthy” diet and AD in the double GSTM1/T1-present genotype group (OR 0.24, 95% CI 0.06-0.93). Results from the multiplicative test analyses showed that the “traditional healthy” diet on reduced AD was significant or borderline significant in the GSTM1-present group (OR 0.71, 95% CI 0.54-0.92 vs. GSTM1-null group) or the GSTM1/T1 double present group (OR 0.63, 95% CI 0.39-1.03 vs. GSTM1/T1 double null group). These findings demonstrate that the present type of GSTM1 may increase susceptibility to the potential effect of the “traditional healthy” diet on AD.
PMID: 26580648 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Conditions: Allergy; Asthma; Rhinitis
Interventions: Drug: Mitizax; Drug: Placebo
Sponsors: Abbott; Linical Co., Ltd; Datamap
Recruiting – verified November 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Conditions: Allergy; Asthma; Rhinitis
Interventions: Drug: Mitizax; Drug: Placebo
Sponsors: Abbott; Linical Co., Ltd; Datamap
Recruiting – verified November 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
 |
Related Articles |
Atopic dermatitis is associated with Caesarean sections in Korean adolescents but asthma is not.
Acta Paediatr. 2015 Sep 12;
Authors: Yu M, Han K, Kim DH, Nam GE
Abstract
AIM: Studies on the associations between mode of delivery and allergic diseases have produced different results and research has rarely been conducted in Asian countries such as South Korea. This study assessed the relationship between mode of delivery and atopic dermatitis and asthma in Korean adolescents.
METHODS: Data collected from the Korea National Health and Nutrition Examination Survey between 2010 and 2011 were used. We included 1,302 adolescents aged from 12-18 years and multivariable logistic regression analysis was performed.
RESULTS: The odds ratio (OR) of having atopic dermatitis was 1.50, with a 95% confidence interval (95% CI) of 1.01-2.22, after adjusting for age and sex. The association remained significant after further adjustments for body mass index, breastfeeding and serum 25-hydroxyvitamin D level (OR = 1.61, 95% CI = 1.05-2.47) and when fat intake was added to those variables (OR = 1.80, 95% CI = 1.14-2.85). However, asthma was not associated with mode of delivery in any of the models.
CONCLUSIONS: Atopic dermatitis in adolescents was associated with Caesarean delivery, which is common in South Korea. The findings suggest that the frequency of this practice should be reconsidered and that further research with longitudinal evaluation of relevant mechanisms is needed. This article is protected by copyright. All rights reserved.
PMID: 26363368 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Genetic Literacy Project |
Asthma and Atopic March Syndrome caused by GMOs? Science says 'No'
Genetic Literacy Project Asthma is a worldwide problem, afflicting more than 230 million people around the globe. It's particularly a problem with children, sending 775,000 of them to the emergency room every year in the United States. It's also more prevalent in … |
View full post on asthma – Google News
Genetic Literacy Project |
Asthma and Atopic March Syndrome caused by GMOs? Independent science …
Genetic Literacy Project Asthma is a worldwide problem, afflicting more than 230 million people around the glove. It's particularly a problem with children, sending 775,000 of them to the emergency room every year in the United States. It's also more prevalent in … |
View full post on asthma – Google News