Tag: Atopy

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Possible Link Between Suicide Risk and Asthma – Atopy Focus of Recent Study – Lung Disease News


Lung Disease News

Possible Link Between Suicide Risk and Asthma – Atopy Focus of Recent Study
Lung Disease News
Asthma and atopy, the genetic tendency to develop allergic diseases, have been suggested to be associated with a higher risk of suicide ideation and depression. Bristol researchers have studied this possible link between pre-defined asthma and atopy …

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Risk of suicide for individuals reporting asthma and atopy in young adulthood: Findings from the Glasgow Alumni study.

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Risk of suicide for individuals reporting asthma and atopy in young adulthood: Findings from the Glasgow Alumni study.

Psychiatry Res. 2014 Dec 19;

Authors: Crawford AA, Galobardes B, Jeffreys M, Davey Smith G, Gunnell D

Abstract
There is emerging evidence that asthma and atopy may be associated with a higher risk of suicide. We investigated the association of asthma and atopy with mortality from suicide (n=32) in the Glasgow Alumni cohort, adjusting for the key confounders of socioeconomic position and smoking. We found no evidence of an association in our a priori atopy phenotypes with suicide, and there were insufficient suicides in the asthma phenotypes to draw any conclusions. In additional analyses, individuals reporting both eczema-urticaria and hay fever and those with family history of atopy were at higher risk of suicide. As these were secondary analyses and based on small numbers of events we cannot rule out chance findings. The lack of evidence in our main hypothesis may be due to the small number of suicides or reported associations between asthma and atopy may be confounded.

PMID: 25596956 [PubMed – as supplied by publisher]

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Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children.

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Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children.

J Allergy Clin Immunol. 2014 May 28;

Authors: Lynch SV, Wood RA, Boushey H, Bacharier LB, Bloomberg GR, Kattan M, O’Connor GT, Sandel MT, Calatroni A, Matsui E, Johnson CC, Lynn H, Visness CM, Jaffee KF, Gergen PJ, Gold DR, Wright RJ, Fujimura K, Rauch M, Busse WW, Gern JE

Abstract
BACKGROUND: Wheezing illnesses cause major morbidity in infants and are frequent precursors to asthma.
OBJECTIVE: We sought to examine environmental factors associated with recurrent wheezing in inner-city environments.
METHODS: The Urban Environment and Childhood Asthma study examined a birth cohort at high risk for asthma (n = 560) in Baltimore, Boston, New York, and St Louis. Environmental assessments included allergen exposure and, in a nested case-control study of 104 children, the bacterial content of house dust collected in the first year of life. Associations were determined among environmental factors, aeroallergen sensitization, and recurrent wheezing at age 3 years.
RESULTS: Cumulative allergen exposure over the first 3 years was associated with allergic sensitization, and sensitization at age 3 years was related to recurrent wheeze. In contrast, first-year exposure to cockroach, mouse, and cat allergens was negatively associated with recurrent wheeze (odds ratio, 0.60, 0.65, and 0.75, respectively; P ? .01). Differences in house dust bacterial content in the first year, especially reduced exposure to specific Firmicutes and Bacteriodetes, was associated with atopy and atopic wheeze. Exposure to high levels of both allergens and this subset of bacteria in the first year of life was most common among children without atopy or wheeze.
CONCLUSIONS: In inner-city environments children with the highest exposure to specific allergens and bacteria during their first year were least likely to have recurrent wheeze and allergic sensitization. These findings suggest that concomitant exposure to high levels of certain allergens and bacteria in early life might be beneficial and suggest new preventive strategies for wheezing and allergic diseases.

PMID: 24908147 [PubMed – as supplied by publisher]

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