A Safety and Efficacy Study of Beclomethasone Dipropionate Delivered Via Breath-Actuated Inhaler (BAI) or Metered-Dose Inhaler (MDI) in Participants Ages 5-11 Years Old With Persistent Asthma

Condition:   Asthma
Interventions:   Drug: Beclomethasone dipropionate;   Drug: Placebo;   Drug: albuterol/salbutamol 90 mcg
Sponsors:   Teva Pharmaceutical Industries;   Teva Branded Pharmaceutical Products, R&D Inc.
Recruiting – verified January 2014

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A Safety and Efficacy Study of Beclomethasone Dipropionate Delivered Via Breath-Actuated Inhaler (BAI) or Metered-Dose Inhaler (MDI) in Participants >=12 Years Old With Persistent Asthma

Condition:   Asthma
Interventions:   Drug: Beclomethasone dipropionate;   Drug: Placebo;   Drug: Albuterol/salbutamol
Sponsors:   Teva Pharmaceutical Industries;   Teva Branded Pharmaceutical Products, R&D Inc.
Recruiting – verified January 2014

View full post on ClinicalTrials.gov: asthma | received in the last 14 days

CLINICAL PHARMACOLOGY STUDY OF A FIXED COMBINATION OF BECLOMETHASONE DIPROPIONATE 50µg PLUS FORMOTEROL FUMARATE 6 µg VERSUS THE FREE COMBINATION OF BECLOMETHASONE HFA pMDI AND FORMOTEROL HFA pMDI AVAILABLE ON THE MARKET USING THE AEROCHAMBER PLUS™ SPACER DEVICE IN ASTHMATIC CHILDREN

Condition:   Asthma
Interventions:   Drug: CHF1535 pMDI + AC Plus;   Drug: BDP and Formoterol + AC Plus
Sponsors:   Chiesi Farmaceutici S.p.A.;   Chiesi Farmaceutici S.p.A.
Completed – verified April 2013

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Safety and efficacy of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with perennial allergic rhinitis.

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Safety and efficacy of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with perennial allergic rhinitis.

Allergy Asthma Proc. 2012 May-Jun;33(3):249-57

Authors: Meltzer EO, Jacobs RL, LaForce CF, Kelley CL, Dunbar SA, Tantry SK

Abstract
Intranasal corticosteroids are recommended as first-line therapy for the treatment of the symptoms of persistent allergic rhinitis (AR). Since the phase-out of chlorofluorocarbon nasal aerosols, intranasal corticosteroids have been available only as aqueous nasal sprays. This study was designed to assess the efficacy, safety, and quality-of-life benefits of beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol in subjects with perennial AR (PAR). After a 7- to 21-day placebo run-in period, eligible subjects aged â�¥12 years with PAR were randomized to 6 weeks of once-daily treatment with BDP nasal aerosol at 320 �¼g or placebo. Reflective and instantaneous total nasal symptom scores (rTNSS and iTNSS, respectively), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score, and physician-assessed total nasal symptom score were evaluated. The primary end point was change from baseline in average morning (A.M.) and evening (P.M.) subject-reported rTNSS over the 6-week treatment period. Safety and tolerability were also assessed. Treatment with BDP nasal aerosol showed significantly greater improvement in average A.M. and P.M. rTNSS compared with placebo (mean treatment difference, -0.84; 95% confidence interval, -1.2, -0.5; p < 0.001). Greater improvements in rTNSS were reported as early as day 1 and were maintained throughout the 6-week treatment period with the exception of day 2. Greater improvements were seen for all four individual nasal symptoms (nasal congestion, nasal itching, rhinorrhea, and sneezing) with BDP nasal aerosol compared with placebo. Similarly, significant improvements were seen in average A.M. and P.M. iTNSS (p < 0.001) and RQLQ score (p = 0.001) with BDP nasal aerosol compared with placebo. In addition, BDP nasal aerosol treatment was well tolerated, and its safety profile was comparable to that of placebo. This clinical study indicated that treatment with BDP nasal aerosol provides statistically significant and clinically meaningful nasal symptom relief accompanied by improved quality of life in subjects with PAR. Additionally, treatment with BDP nasal aerosol was well tolerated with a safety profile comparable to that of placebo. This study was part of the clinical trial NCT01134705 registered in www.ClinicalTrials.gov.

PMID: 22737708 [PubMed – in process]

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Inhaled Beclomethasone Bests Fluticasone (Advair) When HIV PIs Being Used – AIDSmeds.com HIV/AIDS Treatment News

Inhaled Beclomethasone Bests Fluticasone (Advair) When HIV PIs Being Used
AIDSmeds.com HIV/AIDS Treatment News
by Tim Horn Good news for people living with HIV and asthma, bronchitis and chronic obstructive pulmonary disease (COPD). The inhalable steroid beclomethasone can be used at the same time as HIV protease inhibitors without the increased risk of adrenal

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