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Reported link between early life exposure to paracetamol and asthma 'overstated'
Medical Xpress The seven studies covering the potential link between exposure to paracetamol while in the womb and subsequent childhood asthma reached widely varying conclusions, and only one took account of the potential role of respiratory infections during … |
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MESA Analysis Uncovers Link Between Persistent Asthma and Cardiovascular …
Medscape CHICAGO, IL — An analysis from the Multi-Ethnic Study of Atherosclerosis (MESA) suggests there may be an association between persistent asthma and the risk of cardiovascular disease. In a new study presented this week at the American Heart Association … |
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ACAAI moderator: Lines blurring between COPD, asthma
Healio ATLANTA — In this video, Rohit K. Katial, MD, FACAAI, professor of medicine, National Jewish Health, Denver, describes the changing definitions and possible treatments of COPD and asthma. He moderated a session on this subject at the American College … |
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Blur the Lines Between Asthma and COPD, Clinicians Told
Medscape ATLANTA — Clinicians should consider a wider concept of obstructive airway disease, in which either asthma or chronic obstructive pulmonary disease (COPD) predominates, said speakers here at the opening plenary of the American College of Allergy, … |
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Doctors warn of connection between e-cigarettes and asthma
WCBD Dr. Andrew Davidson, Charleston Allergy & Asthma, “E-cigarettes generally contain nicotine, but they don't have the tar that you get from lighting up and smoking a cigarette. The tar causes a lot of damage to the lungs, but nicotine is still something … |
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The Week Magazine |
Study finds link between BPA and asthma
The Week Magazine BPA, a.k.a. the chemical Bisphenol A that's commonly found in plastics and may be linked to cancer, could also be linked to asthma. A new study published in the journal JAMA Pediatrics found that prenatal exposure to BPA could lower children's lung … The Link Between Asthma and This Chemical Can pregnant moms pass asthma along to their babies through plastic? Asthma Linked To BPA: Kids' Poor Lung Health May Be Due To Parental … |
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Medical Daily |
The Link Between Asthma and This Chemical
TIME A 2013 study also found a link between BPA and asthma, and though the mechanism behind the connection is complex and unclear, Spanier sees a definite association. “If my sister who's pregnant asked me for advice, I would tell her try to minimize her … Asthma Linked To BPA: Kids' Poor Lung Health May Be Due To Parental … Study: BPA may not be linked to asthma after all Kids exposed to BPA before birth at risk of wheeze: study |
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Prevention.com |
The Weird New Link Between Work Stress And…Asthma?
Prevention.com Worried your head may soon be on the chopping block? Even if you've never had breathing issues, worrying about losing your job could increase your risk for asthma, suggests a new BMJ study from European and New Zealand researchers. |
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Nature World News |
Study Finds Link Between Maternal Stress and Asthma in Offspring
Nature World News This isn't the first time that stress has been linked to asthma. A recent study had found that mothers who suffer from stressful events such as a divorce, death of a loved one or job loss tend to have a higher risk of having children with asthma or eczema. |
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Bidirectional Cross-Regulation between the Endothelial Nitric Oxide Synthase and ?-Catenin Signaling Pathways.
Cardiovasc Res. 2014 Jul 25;
Authors: Warboys CM, Chen N, Zhang Q, Shaifta Y, Vanderslott G, Passacquale G, Hu Y, Xu Q, Ward JP, Ferro A
Abstract
AIMS: ?-catenin has been shown to be regulated by inducible nitric oxide synthase (NOS) in endothelial cells. We investigated here whether ?-catenin interacts with and regulates endothelial NOS (eNOS) and whether eNOS activation promotes ?-catenin signaling.
METHODS AND RESULTS: We identified ?-catenin as a novel eNOS binding protein in human umbilical vein endothelial cells (HUVECs) by mass spectroscopy and western blot analyses of ?-catenin and eNOS immunoprecipitates. This was confirmed by in situ proximity ligation assay. eNOS activity, assessed by cGMP production and eNOS phosphorylation (Ser1177), was enhanced in ?-catenin(-/-) mouse pulmonary endothelial cells (MPECs) relative to wild type MPECs. eNOS activation (using adenosine, salbutamol, thrombin or histamine), or application of an NO donor (spermine NONOate) or cGMP-analogue (8-bromo-cGMP) caused nuclear translocation of ?-catenin in HUVEC as shown by western blotting of nuclear extracts. Exposure to spermine NONOate, 8-bromo-cGMP or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of ?-catenin-dependent transcripts, IL-8 and cyclin D1. Stimulation of wild type MPECs with basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), spermine NONOate, 8-bromo-cGMP or sildenafil increased tube length relative to controls in an angiogenesis assay. These responses were abrogated in ?-catenin(-/-) MPECs, with the exception of that to bFGF which is NO-independent. In C57BL/6 mice, subcutaneous VEGF-supplemented Matrigel plugs containing ?-catenin(-/-) MPECs exhibited reduced angiogenesis compared to plugs containing wild type MPECs. Angiogenesis was not altered in bFGF-supplemented Matrigel.
CONCLUSIONS: These data reveal bidirectional cross talk and regulation between the NO-cGMP and ?-catenin signaling pathways.
PMID: 25062958 [PubMed – as supplied by publisher]
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