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Delhi Daily News |
Airborne particles beyond traffic fumes may affect asthma risk
Medical Xpress "These effects are likely to contribute to the development of asthma in childhood, as well as to worsening of asthma when pollution levels are high." said Dr. Rakesh Kumar, lead author of the study. "Our findings emphasize that larger airborne … Traffic fume particles aren't asthma triggers, study finds Traffic fume particles do not trigger asthma: Study |
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Asthma infection risk 'goes beyond the airways'
News-Medical.net Researchers from the USA have found that asthma may be associated with an increased risk for infections outside of the respiratory tract. Multiple previous studies have shown that patients with asthma are more likely to experience bacterial infections … |
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Asthma infection risk 'goes beyond the airways'
medwireNews medwireNews: Researchers from the USA have found that asthma may be associated with an increased risk for infections outside of the respiratory tract. Multiple previous studies have shown that patients with asthma are more likely to experience … |
View full post on asthma – Google News
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Cleaning product-related asthma goes beyond irritation
medwireNews medwireNews: Research from Belgium indicates that a substantial proportion of those who have occupational asthma (OA) related to cleaning agents have specific airway sensitivity to the components of detergents. It was previously assumed that the … |
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Cleaning product-related asthma goes beyond irritation
News-Medical.net Research from Belgium indicates that a substantial proportion of those who have occupational asthma (OA) related to cleaning agents have specific airway sensitivity to the components of detergents. It was previously assumed that the ability of such … |
View full post on asthma – Google News
mobihealthnews |
Asthmapolis, now Propeller, moves beyond asthma
mobihealthnews Propeller_RespiratoryManagementPlatform Asthmapolis, the Madison-Wisconsin based smart inhaler company, is changing its name as it moves beyond both asthma treatment and GPS mapping. The company's rebranding as Propeller Health will … Asthmapolis changes name to Propeller Health |
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Rising to the GINA Asthma Challenge: thinking beyond just asthma.
Eur Respir J. 2012 Jul;40(1):281
Authors: Fitzgerald JM, Bateman ED, Hurd S, Boulet LP, Haahtela T, Cruz AA, Levy ML
PMID: 23060648 [PubMed – as supplied by publisher]
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 Vernal Express |
Asthma: sustaining a life beyond the inhaler
Vernal Express She always has to be prepared for an asthma attack. “It's just scary, if you don't have your inhaler and you don't know what to do,” the 15-year-old said. “As a little kid especially you get really scared and then it makes it worse. You get worked up. … |
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 New York Times |
Beyond the Breathalyzer: Seeking Telltale Signs of Disease
New York Times Scientists are building sophisticated electronic and chemical sniffers that examine the puffs of exhaled air for telltale signs of cancer, tuberculosis, asthma and other maladies, as well as for radiation exposure. “There are clear signatures in the … |
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Terminal Signal: Anti-Inflammatory Effects of ?-Melanocyte-Stimulating Hormone Related Peptides Beyond the Pharmacophore.
Adv Exp Med Biol. 2010;681:107-16
Authors: Brzoska T, Böhm M, Lügering A, Loser K, Luger TA
During the last two decades a significant number of investigations has established the fact that ?-Melanocyte-stimulating hormone (?-MSH) is a potent anti-inflammatory mediator. The anti-inflammatory effects of ?-MSH can be elicited via melanocortin receptors (MC-Rs) broadly expressed in a number of tissues ranging from the central nervous system to cells of the immune system and on resident somatic cells of peripheral tissues. ?-MSH affects various pathways regulating inflammatory responses such as NF-?B activation, expression of adhesion molecules, inflammatory cytokines, chemokine receptors, T-cell proliferation and activity and inflammatory cell migration. In vivo ?-MSH has been shown to be anti-inflammatory as well in animal models of fever, irritant and allergic contact dermatitis, cutaneous vasculitis, fibrosis, in ocular, gastrointestinal, brain and allergic airway inflammation and arthritis. A broad range of effects of ?-MSH exerted beyond the field of inflammation, its pigmentory capacity being only the most visible aspect, has been one of the major impediments limiting the use of ?-MSH in human inflammatory disorders. Interestingly KPV, C-terminal tripeptide of ?-MSH, which lacks the entire sequence motif required for binding to any of the known MC-Rs, retains almost all of the anti-inflammatory capacity of the full hormone, but in its activities display a lack of any pigmentory action. While the exact signaling mechanism utilized by KPV and related peptides currently is unknown it has been demonstrated already that significant similarities between anti-inflammatory signaling of ?-MSH and those short peptides exist. These ?-MSH related tripeptides thus may be useful alternatives for anti-inflammatory peptide therapy. KdPT, a derivative of KPV corresponding to IL-1?(193-195), currently is emerging as another tripeptide with potent anti-inflammatory effects. A more limited spectrum of biologic activities, potentially advantageous physicochemical, pharmacokinetic and pharmacodynamic properties as well as the expectation of low costs for pharmaceutical production make these agents interesting candidates for the treatment of immune-mediated inflammatory skin and bowel diseases, allergic asthma and arthritis.
PMID: 21222263 [PubMed – in process]
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