Breathe Well Live Well
Condition: Severe Asthma
Intervention:
Sponsors: Academisch Medisch Centrum – Universiteit van Amsterdam (AMC-UvA); University Medical Center Groningen
Recruiting – verified November 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Condition: Moderate Asthma
Intervention: Device: Bronchial Thermoplasty
Sponsor: Guangzhou Institute of Respiratory Disease
Recruiting – verified November 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Condition: Bronchial Asthma
Interventions: Drug: Ke Chuan Liu Wei Mixture; Drug: Chuan Xiong Ping Chuan Mixture; Drug: Xie Wu Capsule; Drug: Dan Ma Jia Tablet; Drug: Zhi Chuan Capsule; Drug: Bu Shen Na Qi Granule; Drug: Ke Chuan Liu Wei Mixture placebo; Drug: Chuan Xiong Ping Chuan Mixture placebo; Drug: Xie Wu Capsule placebo; Drug: Dan Ma Jia Tablet placebo; Drug: Zhi Chuan Capsule placebo; Drug: Bu Shen Na Qi Granule placebo
Sponsor: Shanghai University of Traditional Chinese Medicine
Not yet recruiting – verified October 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
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Related Articles |
Single-incision video-assisted anatomical segmentectomy with handsewn bronchial closure for endobronchial lipoma.
Ann Transl Med. 2016 Aug;4(15):284
Authors: Galvez C, Sesma J, Bolufer S, Lirio F, Navarro-Martinez J, Galiana M, Baschwitz B, Rivera MJ
Abstract
Endobronchial lipomas are rare benign tumors whose symptoms are usually confused with recurrent infections or even asthma diagnosis, and mostly caused by endobronquial obstructive component which also conditions severity. We report a case of a 60-year-old man with a right-lower lobe upper-segment endobronchial myxoid tumor with uncertain diagnosis. We performed a single incision video-assisted anatomical segmentectomy and wedge bronchoplasty with handsewn closure to achieve complete resection and definitive diagnosis. During the postoperative air leak was not observed and there was no complication, with low pain scores and complete recovery. Final pathological exam showed endobronchial lipoma. Single-incision (SI) anatomical segmentectomies are lung-sparing resections for benign or low-grade malignancies with diagnostic and therapeutic value, and the need for a wedge bronchoplasty is not a necessary indication for conversion to multiport or open thoracotomy.
PMID: 27570778 [PubMed]
View full post on pubmed: asthma
Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor ?1-induced asthmatic bronchial fibroblast-to-myofibroblast transition.
Acta Biochim Pol. 2016 Jul 30;
Authors: Wójcik-Pszczo?a K, Hi?cza K, Wnuk D, K?dzio?ka D, Koczurkiewicz P, Sanak M, Madeja Z, P?kala E, Michalik M
Abstract
Bronchial asthma is characterized by persistent airway inflammation and airway wall remodeling. Among many different cells and growth factors triggering changes in bronchi structure, transforming growth factor ?1-induced fibroblast to myofibroblast transition is believed to be very important. The aim of this study was to evaluate whether theophylline (used in asthma therapy) and two other methylxanthines (pentoxifylline and its active metabolite lisofylline), may affect transforming growth factor ?1-induced fibroblast to myofibroblast transition in bronchial fibroblasts derived from asthmatic patients. We show here for the first time that selected methylxanthines effectively reduce transforming growth factor ?1-induced myofibroblast formation in asthmatic bronchial fibroblast populations. PTX was found to be the most effective methylxanthine. The number of differentiated myofibroblasts after PTX, LSF and THEO administration was reduced at least twofold. Studies on the use of methylxanthines opens a new perspective in the development of novel strategies in asthma therapy through their two-pronged, anti-inflammatory and anti-fibrotic action. In the future they can be considered as promising anti-fibrotic drugs.
PMID: 27474406 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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Hayes, Inc. Releases New Report on Bronchial Thermoplasty for Treatment of Asthma
Benzinga Hayes, Inc., a leading provider of unbiased health technology assessments and consulting services, recently released a health technology assessment on bronchial thermoplasty for the treatment of asthma. Since bronchial thermoplasty is a novel approach … |
View full post on asthma – Google News
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Impacts of coexisting bronchial asthma on severe exacerbations in mild | COPD
Dove Medical Press Backround: Acute exacerbations are major drivers of COPD deterioration. However, limited data are available for the prevalence of severe exacerbations and impact of asthma on severe exacerbations, especially in patients with mild-to-moderate COPD. |
View full post on asthma – Google News
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Bronchial thermoplasty improves asthma regardless of socioeconomic status American College of Chest Physicians
EurekAlert (press release) Shanghai (April 11, 2016)–Among people with asthma, lower socioeconomic status, education level, and ethnic minority status clearly have undesirable effects on their care and outcomes. Patients with severe disease who attend county (public) hospitals … |
View full post on asthma – Google News
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Bronchial thermoplasty improves asthma regardless of socioeconomic status
Medical Xpress Among people with asthma, lower socioeconomic status, education level, and ethnic minority status clearly have undesirable effects on their care and outcomes. Patients with severe disease who attend county (public) hospitals in the United States tend … |
View full post on asthma – Google News
ABC Online |
Bronchial thermoplasty could be a 'game changer' for severe asthma
ABC Online For very severe asthma suffers, everyday life can be tough. Each day can be punctuated by wheezing, breathlessness and chest tightness. But a promising medical procedure that effectively "burns" the inside of the bronchial tubes to widen the airways … |
View full post on asthma – Google News