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Overlake Medical Center offers bronchial thermoplasty for patients with severe …
News-Medical.net Overlake Medical Center in Bellevue is now the only hospital in King County offering bronchial thermoplasty to patients suffering from severe asthma, giving them a non-medicated, proven way to control their asthma symptoms and resulting in 32 percent … |
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Effect of physical training on airway inflammation in bronchial asthma: a …
7thSpace Interactive (press release) The majority of the global population cannot afford existing asthma pharmacotherapy. Physical training as an airway anti-inflammatory therapy for asthma could potentially be a non-invasive, easily available, affordable, and healthy treatment modality. |
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Study: Drug normally used to treat severe bronchial asthma beneficial for …
News-Medical.net An international study involving dermatologists from the Hospital del Mar and Spanish subjects has concluded that a drug normally used to treat severe bronchial asthma caused by allergies (Omalizumab) rapidly eliminates the symptoms of spontaneous … |
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 San Francisco Chronicle (press release) |
Bronchial Asthma Relief Formula Released for Adults at Asthmamist.com
San Francisco Chronicle (press release) Bronchial asthma relief formula is now released online for adults at Asthmamist.com.. This all-natural formula is specifically created to help relieve asthma symptoms to help men and women regain control of their airway using a homeopathic relief solution. |
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 Saudi Gazette |
Treatment options for bronchial asthma discussed
Saudi Gazette JEDDAH – Academics, scientists and doctors gathered in Jeddah on Wednesday night to discuss developments in the treatment of bronchial asthma in children. On behalf of Jeddah Governor Prince Mishaal Bin Majed, who was patron of the conference … |
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Bronchial thermoplasty helps cut down on the frequency, severity of asthma attacks
Reading Eagle "The fumes," Arndt said as he sat in a respiratory therapy room talking about a new therapy available at St. Joseph Medical Center that has changed his life and that he hopes will help a lot more asthma sufferers. Arndt of Palmbay, Fla., was the first … |
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8% children suffering from bronchial asthma in Punjab: Health authorities reveal
Times of India CHANDIGARH: It is not just an increase in the number of asthma cases coming to hospitals and dispensaries across Punjab, but the high incidence of children suffering from respiratory disorders that has become a matter of concern for the health authorities. |
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Bronchial asthma ruled cause of death for Millington football player Dana Payne
Memphis Commercial Appeal Millington High football player Dana Payne died as a result of bronchial asthma with impact to his torso as a contributing factor, according to a report released by the Shelby County medical examiner's office Thursday morning. Payne, 15, died after … |
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Bronchial Hyperresponsiveness to Methacholine and AMP in Children With Atopic Asthma.
Allergy Asthma Immunol Res. 2012 Nov;4(6):341-5
Authors: Kang SH, Kim HY, Seo JH, Kwon JW, Jung YH, Song YH, Hong SJ
Abstract
PURPOSE: Bronchial hyperresponsiveness (BHR) is typically measured by bronchial challenge tests that employ direct stimulation by methacholine or indirect stimulation by adenosine 5′-monophosphate (AMP). Some studies have shown that the AMP challenge test provides a better reflection of airway inflammation, but few studies have examined the relationship between the AMP and methacholine challenge tests in children with asthma. We investigated the relationship between AMP and methacholine testing in children and adolescents with atopic asthma.
METHODS: The medical records of 130 children with atopic asthma (mean age, 10.63 years) were reviewed retrospectively. Methacholine and AMP test results, spirometry, skin prick test results, and blood tests for inflammatory markers (total IgE, eosinophils [total count, percent of white blood cells]) were analyzed.
RESULTS: The concentration of AMP that induces a 20% decline in forced expiratory volume in 1 second [FEV1] (PC20) of methacholine correlated with the PC20 of AMP (r(2)=0.189, P<0.001). No significant differences were observed in the levels of inflammatory markers (total eosinophil count, eosinophil percentage, and total IgE) between groups that were positive and negative for BHR to methacholine. However, significant differences in inflammatory markers were observed in groups that were positive and negative for BHR to AMP (log total eosinophil count, P=0.023; log total IgE, P=0.020, eosinophil percentage, P<0.001). In contrast, body mass index (BMI) was significantly different in the methacholine positive and negative groups (P=0.027), but not in the AMP positive and negative groups (P=0.62). The PC20 of methacholine correlated with FEV1, FEV1/forced vital capacity (FVC), and maximum mid-expiratory flow (MMEF) (P=0.001, 0.011, 0.001, respectively), and the PC20 of AMP correlated with FEV1, FEV1/FVC, and MMEF (P=0.008, 0.046, 0.001, respectively).
CONCLUSIONS: Our results suggest that the AMP and methacholine challenge test results correlated well with respect to determining BHR. The BHR to AMP more likely implicated airway inflammation in children with atopic asthma. In contrast, the BHR to methacholine was related to BMI.
PMID: 23115730 [PubMed – in process]
View full post on pubmed: asthma
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IL-13 exposure enhances vitamin D-mediated expression of the human cathelicidin antimicrobial peptide-hCAP18/LL-37 in bronchial epithelial cells.
Infect Immun. 2012 Oct 8;
Authors: Schrumpf JA, van Sterkenburg MA, Verhoosel RM, Zuyderduyn S, Hiemstra PS
Abstract
Vitamin D is an important regulator of the expression of antimicrobial peptides, and vitamin D deficiency is associated with respiratory infections. Regulating expression of antimicrobial peptides such as the human cathelicidin antimicrobial peptide (hCAP)18/LL-37 by vitamin D in bronchial epithelial cells requires local conversion of 25(OH)vitaminD(3) (25D(3)) into its bioactive metabolite 1,25(OH)(2)vitaminD(3) (1,25D(3)) by CYP27B1. Low circulating vitamin D-levels in childhood asthma are associated with more severe exacerbations, which are often associated with infections. Atopic asthma is accompanied by Th2 driven inflammation mediated by cytokines such as IL-4 and IL-13, and the effect of these cytokines on vitamin D metabolism and hCAP-18/LL-37 expression is unknown. Therefore we investigated this in well-differentiated bronchial epithelial cells. To this end, cells were treated with IL-13 with and without 25D(3) and expression of hCAP18/LL-37, CYP27B1, the 1,25D(3) inactivating enzyme CYP24A1, and vitamin D receptor was assessed by quantitative PCR. We show that IL-13 enhances the ability of 25D(3) to increase expression of hCAP18/LL-37 and CYP24A1. In addition, exposure to IL-13 resulted in increased CYP27B1 expression, whereas VDR expression was not significantly affected. The enhancing effect of IL-13 on 25D(3)-mediated expression of hCAP18/LL-37 was further confirmed using SDS-PAGE Western Blot and immunofluorescence staining. In conclusion, we demonstrate that IL-13 induces vitamin D(-)dependent hCAP18/LL-37 expression, most likely by increasing CYP27B1. These data suggest that Th2 cytokines regulate the vitamin D metabolic pathway in bronchial epithelial cells.
PMID: 23045480 [PubMed – as supplied by publisher]
View full post on pubmed: asthma