MESA Analysis Uncovers Link Between Persistent Asthma and Cardiovascular … – Medscape

MESA Analysis Uncovers Link Between Persistent Asthma and Cardiovascular
Medscape
CHICAGO, IL — An analysis from the Multi-Ethnic Study of Atherosclerosis (MESA) suggests there may be an association between persistent asthma and the risk of cardiovascular disease. In a new study presented this week at the American Heart Association …

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FDA slaps cardiovascular warnings on Roche/Novartis asthma blockbuster Xolair – FiercePharma


Fox News

FDA slaps cardiovascular warnings on Roche/Novartis asthma blockbuster Xolair
FiercePharma
It was way back in 2009 when the FDA first indicated it was worried about reports of heart attacks and strokes in patients taking Xolair, the asthma treatment co-marketed by Novartis ($NVS) and Roche ($RHHBY). Now the agency is taking action, slapping …
FDA says asthma drug Xolair raises risk of heart, brain problemsFox News
Heart, Mini-Stroke Risks From Asthma Drug: FDAWebMD
FDA adds cardiovascular risks to Xolair label for asthma treatmentHealio
ModernMedicine
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A Computational Physiology Approach to Personalized Treatment Models: The Beneficial Effects of Slow Breathing on the Human Cardiovascular System.

A Computational Physiology Approach to Personalized Treatment Models: The Beneficial Effects of Slow Breathing on the Human Cardiovascular System.

Am J Physiol Heart Circ Physiol. 2014 Jul 25;

Authors: Fonoberova M, Mezic I, Buckman JF, Fonoberov VA, Mezic A, Vaschillo E, Mun EY, Vaschillo B, Bates ME

Abstract
Heart rate variability biofeedback intervention involves slow breathing at a rate of ~6 breaths per min (resonance breathing) to maximize respiratory and baroreflex effects on heart period oscillations. This intervention has wide-ranging clinical benefits and is gaining empirical support as an adjunct therapy for biobehavioral disorders, including asthma and depression. Yet, little is known about the system-level cardiovascular changes that occur during resonance breathing or the extent to which individuals differ in cardiovascular benefit. This study used a computational physiology approach to dynamically model the human cardiovascular system at rest and during resonance breathing. Noninvasive measurements of heart period, beat-to-beat systolic and diastolic blood pressure, and respiration period were obtained from 24 healthy young men and women. A model with respiration as input was parameterized to better understand how the cardiovascular processes that control variability in heart period and blood pressure change from rest to resonance breathing. The cost function used in model calibration corresponded to the difference between the experimental data and model outputs. A good match was observed between the data and model outputs (heart period, blood pressure, and corresponding power spectral densities). Significant improvements in several modeled cardiovascular functions (e.g., blood flow to internal organs, sensitivity of the sympathetic component of the baroreflex, ventricular elastance) were observed during resonance breathing. Individual differences in the magnitude and nature of these dynamic responses suggest that computational physiology may be clinically useful for tailoring heart rate variability biofeedback interventions for the needs of individual patients.

PMID: 25063789 [PubMed – as supplied by publisher]

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