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Study links adverse childhood experiences to pediatric asthma
Medical Xpress Robyn Wing, M.D., an emergency medicine physician at Hasbro Children's Hospital, recently led a study that found children who were exposed to an adverse childhood experience (ACE) were 28 percent more likely to develop asthma. The rate of asthma … |
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Exposure to Indoor Pollutants and Wheeze and Asthma Development during Early Childhood.
Int J Environ Res Public Health. 2015;12(4):3993-4017
Authors: Patelarou E, Tzanakis N, Kelly FJ
Abstract
BACKGROUND: This review aimed to summarize existing epidemiological evidence of the association between quantitative estimates of indoor air pollution with early childhood respiratory disease.
METHODS: We carried out a systematic literature search of peer-reviewed epidemiological studies undertaken in “westernized” countries that have assessed exposure to indoor pollutants and asthma and wheeze from infancy up to the age of 5.
RESULTS: The search, between January 2004 and February 2014 yielded 1840 studies for consideration. Following application of eligibility criteria to titles and abstracts 22 independent studies were deemed relevant for further review. Two additional studies were next identified through examination of the references’ lists of these studies. Of these 24 selected studies, 16 adopted a prospective cohort design and 8 were case-control studies. Fourteen studies assessed exposure to bio-aerosols, 8 studies assessed exposure to specific air chemicals and two studies assessed exposure to bio-aerosols and air chemicals. Furthermore, 11 studies examined the association of exposure with asthma and 16 with wheeze. Findings indicate that existing studies have reported contradictory effects of indoor pollutants levels and occurrence of asthma/wheeze.
CONCLUSION: Additional research to establish causality and evaluate interventions to prevent disease onset is needed.
PMID: 25872014 [PubMed – as supplied by publisher]
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Greene County Democrat |
Newswire : Obama links Malia's childhood asthma with global warming in a …
Greene County Democrat Well you know Malia had asthma when she was four and because we had good health insurance, we were able to knock it out early … And if we can make sure that our responses to the environment are reducing those incidents, that's something that I think … Nationwide Climate Change Initiative Targets COPD, Asthma Diagnosing the link between health and climate change Report: Climate Change is Dangerous to Your Health |
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Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.
J Allergy Clin Immunol. 2015 Apr 9;
Authors: Persson H, Kwon AT, Ramilowski JA, Silberberg G, Söderhäll C, Orsmark-Pietras C, Nordlund B, Konradsen JR, de Hoon MJ, Melén E, Hayashizaki Y, Hedlin G, Kere J, Daub CO
Abstract
BACKGROUND: Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, such as smoking or allergies, are found after extensive investigation, these children are given a diagnosis of therapy-resistant (or therapy-refractory) asthma (SA).
OBJECTIVE: We sought to deepen our understanding of childhood SA by analyzing gene expression and modeling the underlying regulatory transcription factor networks in peripheral blood leukocytes.
METHODS: Gene expression was analyzed by using Cap Analysis of Gene Expression in children with SA (n = 13), children with controlled persistent asthma (n = 15), and age-matched healthy control subjects (n = 9). Cap Analysis of Gene Expression sequencing detects the transcription start sites of known and novel mRNAs and noncoding RNAs.
RESULTS: Sample groups could be separated by hierarchical clustering on 1305 differentially expressed transcription start sites, including 816 known genes and several novel transcripts. Ten of 13 tested novel transcripts were validated by means of RT-PCR and Sanger sequencing. Expression of RAR-related orphan receptor A (RORA), which has been linked to asthma in genome-wide association studies, was significantly upregulated in patients with SA. Gene network modeling revealed decreased glucocorticoid receptor signaling and increased activity of the mitogen-activated protein kinase and Jun kinase cascades in patients with SA.
CONCLUSION: Circulating leukocytes from children with controlled asthma and those with SA have distinct gene expression profiles, demonstrating the possible development of specific molecular biomarkers and supporting the need for novel therapeutic approaches.
PMID: 25863981 [PubMed – as supplied by publisher]
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Bustle |
Obama Links Malia's Childhood Asthma With Global Warming In A Powerful Call …
Bustle Well you know Malia had asthma when she was four and because we had good health insurance, we were able to knock it out early … And if we can make sure that our responses to the environment are reducing those incidents, that's something that I think … President Obama's favorite Republican? 'I love them all' |
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Poverty, Not Air Pollution Causing Childhood Asthma, Study Finds
The Heartland Institute A new study authored by a research team led by Dr. Corrine Keet of John's Hopkins Children's Center has found no link between outdoor air pollution and childhood asthma. Dr. Keet's team followed 23,000 U.S. children and found no statistically … |
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Condition: Childhood Asthma
Interventions: Behavioral: ACT; Behavioral: An educational talk
Sponsors: The Hong Kong Polytechnic University; Hospital Authority, Hong Kong
Not yet recruiting – verified April 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Examiner.com |
Childhood trauma linked to increased risk of asthma
Examiner.com The children of families who experience trauma such as divorce, domestic violence or the death of a parent may be at greater risk for developing asthma, according to an April 2 news release from the American College of Allergy, Asthma and Immunology … |
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WFMJ |
Childhood trauma may raise odds of asthma
WFMJ FRIDAY, April 3, 2015 (HealthDay News) — Children who experience trauma such as divorce, death of a parent or domestic violence are more likely to develop asthma than other kids, new research suggests. "We know that young children are susceptible to … Adverse childhood experiences increase a child's risk for asthma Adverse Childhood Experiences Make Children More Susceptible to Asthma |
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Lung Disease News |
Childhood Trauma May Raise Odds of Asthma
U.S. News & World Report FRIDAY, April 3, 2015 (HealthDay News) — Children who experience trauma such as divorce, death of a parent or domestic violence are more likely to develop asthma than other kids, new research suggests. "We know that young children are susceptible to … Adverse Childhood Experiences Make Children More Susceptible to Asthma Adverse childhood experiences increase a child's risk for asthma |
View full post on asthma – Google News