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Pharmacy Times |
Asthma: Helping Children and Caregivers Breathe Easier
Pharmacy Times Asthma, a chronic inflammatory disease that occurs in the airways due to a complex interaction of factors,1 is characterized by symptoms that cause reversible airway narrowing and increased airway responsiveness to a variety of stimuli. The reversible … |
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FoxP3 Tregs Response to Sublingual Allergen Specific Immunotherapy in Children Depends on the Manifestation of Allergy.
J Immunol Res. 2015;2015:731381
Authors: Stelmaszczyk-Emmel A, Zawadzka-Krajewska A, G?odkowska-Mrówka E, Demkow U
Abstract
Over the last decades allergic diseases has become a major health problem worldwide. The only specific treatment to date is allergen specific immunotherapy (ASIT). Although it was shown that ASIT generates allergen-tolerant T cells, detailed mechanism underlying its activity is still unclear and there is no reliable method to monitor its effectiveness. The aim of our study was to evaluate ASIT influence on the frequency of forkhead box P3 (FoxP3) Tregs in allergic children with various clinical manifestations. The relative number of FoxP3 Tregs in 32 blood samples from allergic children at baseline and/or after 1 year of ASIT was assessed by flow cytometry. In the entire studied group, the percentage of FoxP3 Tregs did not increase 1 year after ASIT. Nevertheless, the percentage of FoxP3 Tregs after ASIT significantly increased in children with respiratory allergy (conjunctivitis, asthma, and rhinitis) coexisting with nonrespiratory manifestations (food allergy and/or atopic dermatitis), whereas, in patients with respiratory allergy only, the percentage of FoxP3 Tregs decreased. To the best of our knowledge, this is the first report showing various differential FoxP3 Tregs response to ASIT in allergic children. FoxP3 Tregs number could be useful in treatment monitoring. Further studies are warranted to confirm these observations.
PMID: 26457309 [PubMed – in process]
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iMedicalApps |
Roche Asthma app aimed at parents of children involved in clinical trial
iMedicalApps The study is for adolescents with uncontrolled asthma who are failing with standard of care therapy. Roche is studying an immunomodulator in this patient group. What's interesting about the AsthmApp is it's not aimed at the study participants, but the … |
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ABC2 News |
Exposure to mold could lead children to develop asthma, other illnesses
ABC2 News An exposure to mold in a child's early years could lead to the development of asthma and other health problems, according to the U.S. Centers for Disease Control and Prevention. The Institute of Medicine has also found evidence linking indoor exposure … |
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Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-?, IL-?, IL-6 and IL-17A.
Immunobiology. 2015 Sep 8;
Authors: Charrad R, Berraïes A, Hamdi B, Ammar J, Hamzaoui K, Hamzaoui A
Abstract
BACKGROUND: The aim of this study was to assess interleukin (IL)-37 production in asthmatic children in serum and induced sputum and to look to the impact of IL-37 on pro-inflammatory cytokines production (TNF-?, IL-6, IL-1? and IL-17).
METHODS: Forty children with well-controlled asthma (20 moderate and 20 mild asthmatics) were studied. IL-37 was measured by ELISA in serum and induced sputum (IS) samples, and compared with 22 age- and sex-matched healthy controls. Real-time quantitative PCR was used to determine IL-37 mRNA expression in induced sputum cells. Induced sputum mononuclear cells from 10 moderate asthmatics and 10 healthy controls were stimulated either with lipopolysaccharides (LPS) or LPS plus recombinant IL-37 (rIL-37) comparing pro-inflammatory cytokines production. TNF-?, IL-1?, IL-6 and IL-17 were measured by RT-PCR and ELISA.
FINDINGS: The expression of IL-37 mRNA in asthmatic patients was significantly lower than that observed in healthy controls (P=0.0001). IL37 mRNA expression depended on asthma severity. Serum and IS IL-37 levels were significantly lower in asthma patients compared to healthy controls. LPS-stimulated sputum cells from asthma patients produced higher levels of IL-1?, IL-6, and TNF-? than those from HC. Adding rIL-37 suppressed TNF-?, IL-1? and IL-6 production in IS cells. In the same way, stimulating IS CD4(+) T cells in the presence of rIL-37 inhibited IL-17 production both in asthma patients and HC. IL-37 effect on IL-17 was more pronounced in patients than controls.
INTERPRETATION: The decrease in IL-37 level observed in IS was found to correlate with disease severity. The increased pro-inflammatory cytokines production from asthma IS cells was abrogated by the addition of rIL-37. IL-37 could be an important cytokine in the control of asthma by suppressing the production of inflammatory cytokines.
PMID: 26454413 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Press Examiner |
Asthma Medication Makes Children Shorter
Press Examiner Physicians often prescribe corticosteroids to manage symptoms of asthma. However, according to the findings of a recent study, children with asthma who take inhaled steroids end up slightly shorter than their peers when they grow up. Inhaled steroids … |
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Caregiver treatment satisfaction is improved together with children’s asthma control: Prospective study for budesonide monotherapy in school-aged children with uncontrolled asthma symptoms.
Allergol Int. 2015 Oct;64(4):371-6
Authors: Yoshihara S, Kanno N, Fukuda H, Arisaka O, Arita M, Sekine K, Yamaguchi K, Tsuchida A, Yamada Y, Watanabe T, Shimizu T, Nishikawa K, Nishimuta T
Abstract
BACKGROUND: If asthmatic children cannot obtain sufficient control of their disease, not only do they suffer from asthma symptoms, but the daily life activities of their caregivers are also disrupted. We investigated the effectiveness of an inhaled corticosteroid (ICS) for symptom control in previously ICS-untreated school-aged asthmatic children as well as caregiver treatment satisfaction (CTS).
METHODS: A multicenter, open-label, single-arm study on 12-week ICS (budesonide Turbuhaler(®)) monotherapy was undertaken in subjects aged 5-15 years with bronchial asthma not treated with ICS during the previous 3 months. At 0, 4, 8, and 12 weeks after start of ICS administration, Japanese Pediatric Asthma Control Program (JPAC) scores, and CTS scores were summated and lung function measured. At weeks 0 and 12, questionnaires on caregiver anxiety were also assessed.
RESULTS: Seventy-five patients were enrolled, and 69 assessed. Ninety percent of subjects had been treated with asthma controller medication except ICS before study enrollment. JPAC score and CTS score were improved significantly at weeks 4, 8, and 12 (p < 0.001). With regard to CTS, more than half of caregivers showed a perfect score at weeks 8 and 12. There was a significant correlation between JPAC score and CTS score. Lung function and caregiver anxiety were also improved, and good compliance with treatment was observed during the intervention.
CONCLUSIONS: If treating ICS-untreated school-aged asthmatic children with uncontrolled symptoms, ICS monotherapy can improve CTS along with improving asthma control.
PMID: 26433534 [PubMed – in process]
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FOXP3 mRNA expression lower among children with asthma, food allergy
Healio Aneta Krogulska, MD, PhD, of the department of pediatric allergology, gastroenterology and nutrition at Medical University of Lodz in Poland, and colleagues assessed FOXP3 mRNA expression in 82 children with asthma. Fifteen had atopic asthma and an … |
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Nature World Report |
Asthma medications during infancy lead to stunted growth in children
Nature World Report Researchers from Kuopio University Hospital and University of Eastern Finland analysed information on the height, weight and asthma medicine intake of 12,482 Finnish children aged 0-24 months. They found that children who used inhaled corticosteroids … Asthma steroids 'could stunt growth' Asthma medication stunts growth among infants: Finnish Research Asthma Medications Use In Pre-School Children Can Develop Growth Problems |
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Nature World Report |
Asthma medications during infancy affect growth in children
Nature World Report According to research presented today at the 54th Annual European Society for Paediatric Endocrinology Meeting, infants given asthma medications during their first 2 years of age are likely to be stunted in later life. The findings highlight the … Asthma steroids 'could stunt growth' Infant use of asthma medication linked to stunted growth Some asthma inhalers 'could stunt growth' in children, study finds |
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