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Electronic nose can detect sub-groups of asthma in children
Science Codex The new research, presented at the European Respiratory Society (ERS) International Congress in Munich today (7 September 2014), is part of the U-BIOPRED* project to learn more about different types of asthma to ensure better diagnosis and treatment … |
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ABC News |
Respiratory Virus Sickening Children in Colorado
ABC News Dr. Christine Nyquist, a pediatrician at Children's Hospital Colorado, said the virus usually ends up appearing similar to a severe cold but can be particularly dangerous for children with asthma because of how it affects the respiratory system. "The … |
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University Herald |
Overweight Children Are More Likely to Develop Asthma
University Herald Although the link between childhood obesity and asthma has been known for years, researchers have not been able to determine which conditions tends to come first, or whether one causes the other. Researchers found that it is more probable that … For kids with both asthma and obesity, which came first? First report of allergic reaction to antibiotic pesticides consumed in food Farm Antibiotics May Be Linked to Food Allergies |
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Daily News & Analysis |
Overweight children face risk of getting asthma: Research
Daily News & Analysis If your child is overweight, there's one more reason for you to worry. In addition to the usual, risk of obesity and its associated health complications there's a risk of him/her getting asthma too. And if your child is overweight and has asthma too … |
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Condition: Asthma
Intervention: Other: Survey
Sponsor: Children’s Research Institute
Not yet recruiting – verified August 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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September is a wicked month for children with asthma
Irish Times Their GP prescribed a reliever inhaler to be used with an aerochamber, but he was young for a diagnosis of asthma, so he wasn't given preventative medication and they had to wait a year to see a respiratory consultant in Tallaght hospital. The Dunnes … |
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Back-to-School Tips For Parents of Children With Asthma
Public News Service PHOTO: Rescue inhalers are an important part of the life of a child with asthma. The American Lung Association says it's important to have an asthma action plan for your school-age child, and to discuss it with the school nurse. (Photo courtesy of … |
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| Related Articles |
Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children.
Immunobiology. 2014 Jul 22;
Authors: Hamzaoui A, Berraïes A, Hamdi B, Kaabachi W, Ammar J, Hamzaoui K
Abstract
Vitamin D [25(OH)D3] deficiency has been associated with asthma as in many inflammatory and autoimmune pathologies; however, there is still a lack of data about the effects of administration of vitamin D in immune regulation in young asthmatic patients. In this study, we investigated its inhibitory effect on the immune response in young asthmatic patients and the possible mechanisms involved. Peripheral blood CD4(+) T cells from 10 asthmatic patients and 10 healthy controls were cultured under Th17 polarizing conditions in the presence or absence of [25(OH)D3], IL-17 cytokine production was determined by ELISA and flow cytometry. Messenger RNA (mRNA) expression of several factors related to Th17 cell function was determined by real-time PCR. The effect of [25(OH)D3]-treated dendritic cells (DCs) on CD4(+) T cell response was determined by ELISA and flow cytometry. Stimulation of naive CD4(+) T cells under Th17 polarizing conditions showed a higher Th17 cell differentiation in asthmatic patients than healthy controls. The addition of [25(OH)D3] significantly inhibited Th17 cell differentiation both in patients [P<0.001] and in normal controls [P=0.001] in a dose-dependent way. [25(OH)D3] was able to inhibit the gene expression of RORC, IL-17, IL-23R, and CCR6. [25(OH)D3]-treated DCs significantly inhibited IL-17 production [P=0.002] and decreased the percentage of CD4(+)IL-17(+) [P=0.007] in young asthmatics. The findings suggest that the inhibitory effect of [25(OH)D3] on the Th17 response was mediated via both T cells and DCs. DCs pathway is involved in the direct inhibition of 25(OH)D3 on Th17 cell differentiation in young asthmatics.
PMID: 25128460 [PubMed – as supplied by publisher]
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Camp Wheeze Away gives children with asthma 'normal' summer fun
Killeen Daily Herald Dana Green, a member of the summer staff at Peaceable Kingdom Retreat, helps Kaitie McClendon, 9, of Lampasas, with her form as some of the participants at Camp Wheeze Away try out their archery skills. Camp Wheeze Away is for children with asthma. |
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Long Beach Alliance for Children with Asthma granted $70000 by HCBF
Orange County Breeze The Long Beach Alliance for Children with Asthma, a community coalition organized under the institutional umbrella of Miller Children's & Women's Hospital Long Beach, was awarded a $70,000 grant from the Harbor Community Benefit Foundation (HCBF). |
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