Diffusion lung capacity of carbon monoxide: A novel marker of airways remodeling in asthmatic children?

Diffusion lung capacity of carbon monoxide: A novel marker of airways remodeling in asthmatic children?

Allergy Rhinol (Providence). 2012;3(2):e66-73

Authors: Piacentini GL, Tezza G, Cattazzo E, Kantar A, Ragazzo V, Boner AL, Peroni DG

Abstract
Asthma is universally considered a chronic inflammatory disorder of the airways. Several noninvasive markers, such as exhaled nitric oxide (FeNO) and exhaled breath temperature (PletM), have been proposed to evaluate the degree of airway inflammation and remodeling in asthmatic children. The aim of this study was to evaluate the relationship between diffusion lung capacity of carbon monoxide (DLCO) and these inflammatory markers in asthmatic children. We compared data of FeNO, PletM, and DLCO collected in 35 asthmatic children at admission (T0) and discharge (T1) after a period spent in a dust-mite-free environment (Misurina, Italian Dolomites, 1756 m). PletM showed a reduction from 29.48°C at T0 to 29.13°C at T1 (p = 0.17); DLCO passed from 93 to 102 (p = 0.085). FeNO mean value was 29.7 ppb at admission and 18.9 ppb at discharge (p = 0.014). Eosinophil mean count in induced sputum was 4 at T0 and 2 at T1 (p = 0.004). Spearman standardization coefficient beta was 0.414 between eosinophils and FeNO and -0.278 between eosinophils and DLCO. Pearson’s correlation index between DLCO and PletM was -0.456 (p = 0.019). A negative correlation between DLCO and PletM was found. However, DLCO did not show a significant correlation with FeNO and eosinophils in the airways. Additional studies are needed to clarify the role of DLCO as a potential tool in monitoring childhood asthma.

PMID: 23342292 [PubMed – in process]

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Asthma Cases in Children Fall in Wake of Smoke-Free Laws – WebProNews


The Inquisitr

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WebProNews
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Telegraph.co.uk

Number of children admitted to hosptal with asthma falls since smoking ban
Telegraph.co.uk
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Press TV

Fast food increases asthma, eczema risk in children
Press TV
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Monthly Prescribing Reference
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Three-year-old Charles Clarke Jr. gets an H1N1 swine flu vaccine injection in his leg at an Asthma fair at Children's Hospital in BostonWASHINGTON (Reuters) – The current guideline for immunizing children against polio, whooping cough, measles and other infectious diseases is safe, but should still be monitored, federal health advisers said on Wednesday. In what they called the most comprehensive review to date, scientists at the Institute of Medicine (IOM) said there is no evidence that giving children vaccines according to the recommended timetable causes other problems such as autism or asthma. …


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