Breathe Well Live Well
Conditions: Pain; Trismus; Edema
Interventions: Drug: mepivacaine chloridrato epinephrine; Drug: mepivacaine chloridrato levonordefrin
Sponsor: University of Sao Paulo
Active, not recruiting – verified November 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
| Related Articles |
Comparative proteomics of inhaled silver nanoparticles in healthy and allergen provoked mice.
Int J Nanomedicine. 2013;8:2783-99
Authors: Su CL, Chen TT, Chang CC, Chuang KJ, Wu CK, Liu WT, Ho KF, Lee KY, Ho SC, Tseng HE, Chuang HC, Cheng TJ
Abstract
BACKGROUND: Silver nanoparticles (AgNPs) have been associated with the exacerbation of asthma; however, the immunological basis for the adjuvant effects of AgNPs is not well understood.
OBJECTIVE: The aim of the study reported here was to investigate the allergic effects of AgNP inhalation using proteomic approaches.
METHODS: Allergen provoked mice were exposed to 33 nm AgNPs at 3.3 mg/m(3). Following this, bronchoalveolar lavage fluid (BALF) and plasma were collected to determine protein profiles.
RESULTS: In total, 106 and 79 AgNP-unique proteins were identified in the BALF of control and allergic mice, respectively. Additionally, 40 and 26 AgNP-unique proteins were found in the plasma of control and allergic mice, respectively. The BALF and plasma protein profiles suggested that metabolic, cellular, and immune system processes were associated with pulmonary exposure to AgNPs. In addition, we observed 18 proteins associated with systemic lupus erythematosus that were commonly expressed in both control and allergic mice after AgNP exposure. Significant allergy responses were observed after AgNP exposure in control and allergic mice, as determined by ovalbumin-specific immunoglobulin E.
CONCLUSION: Inhaled AgNPs may regulate immune responses in the lungs of both control and allergic mice. Our results suggest that immunology is a vital response to AgNPs.
PMID: 23946650 [PubMed – in process]
View full post on pubmed: asthma
Condition: Handling of Auto-injectors
Intervention: Drug: Adrenaline auto-injector
Sponsors: ALK Nordic A/S, Danmark Filial; ALK Nordic A/S, Danmark Filial
Completed – verified June 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Harvard Clinical Research Institute Initiates Comparative Effectiveness Study …
Business Wire (press release) Tiotropium) Study, the purpose of which is to investigate whether Black patients with asthma are more likely to experience adverse outcomes as a result of long-acting beta-agonist (LABA) therapy. The BELT study was funded by a grant from the Agency for … |
View full post on asthma – Google News
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Harvard Clinical Research Institute Initiates Comparative Effectiveness Study …
Genetic Engineering News Tiotropium) Study, the purpose of which is to investigate whether Black patients with asthma are more likely to experience adverse outcomes as a result of long-acting beta-agonist (LABA) therapy. The BELT study was funded by a grant from the Agency for … |
View full post on asthma – Google News
Condition: Asthma
Interventions: Drug: Seretide 250(8puffs) via Evohaler actuator; Drug: Seretide 250 (8 puffs)/placebo via Volumatic spacer; Drug: Seretide 250/placebo 8 puffs via Aerochamber Plus spacer; Drug: Seretide 250/placebo via Synchro-Breathe
Sponsor: University of Dundee
Completed – verified December 2009
View full post on ClinicalTrials.gov: “Asthma” | updated in the last 30 days
Condition: Asthma
Interventions: Drug: Formoterol/Fluticasone; Drug: Foraseq®; Drug: Fluticasone
Sponsor: Eurofarma Laboratorios Ltda
Not yet recruiting – verified September 2010
View full post on ClinicalTrials.gov: “Asthma” | updated in the last 30 days
Condition: Asthma
Interventions: Drug: Salmeterol/Fluticasone; Drug: Seretide
Sponsor: Eurofarma Laboratorios Ltda
Not yet recruiting – verified September 2010
View full post on ClinicalTrials.gov: “Asthma” | updated in the last 30 days