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The asthma–COPD overlap syndrome: do we really need another syndrome in the already complex matrix of airway …
Dove Medical Press Abstract: The term asthma–COPD overlap syndrome (ACOS) is one of multiple terms used to describe patients with characteristics of both COPD and asthma, representing ~20% of patients with obstructive airway diseases. The recognition of both sets of … |
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EurekAlert (press release) |
Technology to crowdsource complex triggers of pediatric asthma
EurekAlert (press release) Facelli, along with co-principal investigator Kathy Sward, Ph.D., R.N., associate professor of biomedical informatics research at the College of Nursing, is leading teams to create an Internet-based "infrastructure" that will enable kids with asthma … |
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Related Articles |
Bronchial lesions of mouse model of asthma are preceded by immune complex vasculitis and induced bronchial associated lymphoid tissue (iBALT).
Lab Invest. 2015 Jun 1;
Authors: Guest IC, Sell S
Abstract
We systematically examined by immune histology the lungs of some widely used mouse models of asthma. These models include sensitization by multiple intraperitoneal injections of soluble ovalbumin (OVA) or of OVA with alum, followed by three intranasal or aerosol challenges 3 days apart. Within 24?h after a single challenge there is fibrinoid necrosis of arterial walls with deposition of immunoglobulin (Ig) and OVA and infiltration of eosinophilic polymorphonuclear cells that lasts for about 3 days followed by peribronchial B-cell infiltration and slight reversible goblet cell hypertrophy (GCHT). After two challenges, severe eosinophilic vasculitis is present at 6?h, increases by 72?h, and then declines; B-cell proliferation and significant GCHT and hyperplasia (GCHTH) and bronchial smooth muscle hypertrophy recur more prominently. After three challenges, there is significantly increased induced bronchus-associated lymphoid tissue (iBALT) formation, GCHTH, and smooth muscle hypertrophy. Elevated levels of Th2 cytokines, IL-4, IL-5, and IL-13, are present in bronchial lavage fluids. Sensitized mice have precipitating antibody and positive Arthus skin reactions but also develop significant levels of IgE antibody to OVA but only 1 week after challenge. We conclude that the asthma like lung lesions induced in these models is preceded by immune complex-mediated eosinophilic vasculitis and iBALT formation. There are elevations of Th2 cytokines that most likely produce bronchial lesions that resemble human asthma. However, it is unlikely that mast cell-activated atopic mechanisms are responsible as we found only a few presumed mast cells by toluidine blue and metachromatic staining limited to the most proximal part of the main stem bronchus, and none in the remaining main stem bronchus or in the lung periphery.Laboratory Investigation advance online publication, 1 June 2015; doi:10.1038/labinvest.2015.72.
PMID: 26006019 [PubMed – as supplied by publisher]
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Bronchial lesions of mouse model of asthma are preceded by immune complex …
Nature.com We systematically examined by immune histology the lungs of some widely used mouse models of asthma. These models include sensitization by multiple intraperitoneal injections of soluble ovalbumin (OVA) or of OVA with alum, followed by three intranasal … |
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Complex interventions reduce use of urgent healthcare in adults with asthma: Systematic review with meta-regression.
Respir Med. 2014 Nov 15;
Authors: Blakemore A, Dickens C, Anderson R, Tomenson B, Woodcock A, Guthrie E
Abstract
INTRODUCTION: Asthma accounts for considerable healthcare expenditure, a large proportion of which is attributable to use of expensive urgent healthcare. This review examines the characteristics of complex interventions that reduce urgent healthcare use in adults with asthma.
METHOD: Electronic searches of MEDLINE, EMBASE, PSYCINFO, CINAHL, the British Nursing Library and the Cochrane library, from inception to January 2013 were conducted. Studies were eligible for inclusion if they: i) included adults with asthma ii) assessed the efficacy of a complex intervention using randomised controlled trial design, and iii) included a measure of urgent healthcare utilisation at follow-up. Data on participants recruited, methods, characteristics of complex interventions and the effects of the intervention on urgent healthcare use were extracted.
RESULTS: 33 independent studies were identified resulting in 39 comparisons altogether. Pooled effects indicated that interventions were associated with a reduction in urgent healthcare use (OR = 0.79, 95% CI = 0.67, 0.94). When study effects were grouped according to the components of the interventions used, significant effects were seen for interventions that included general education (OR = 0.77, 95% CI = 0.64, 0.91), skills training (OR = 0.64, 95% CI = 0.48, 0.86) and relapse prevention (OR = 0.75, 95% CI = 0.57, 0.98). In multivariate meta-regression analysis, only skills training remained significant.
CONCLUSIONS: Complex interventions reduced the use of urgent healthcare in adults with asthma by 21%. Those complex interventions including skills training, education and relapse prevention may be particularly effective in reducing the use of urgent healthcare in adults with asthma.
PMID: 25433953 [PubMed – as supplied by publisher]
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Medscape |
Complex Link Between Early Antibiotics and Asthma
Medscape Impaired antiviral immunity and genetic variants may play roles in the link between early antibiotic use and subsequent asthma, according to a UK study by Aida Semic-Jusufagic, MD, from the Centre for Respiratory Medicine and Allergy, Institute of … Link Between Early Antibiotic Use & Asthma Probed Genetic variants may explain link between infant antibiotic use and asthma Antibiotics might not be behind your kid's asthma |
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Asthma and Comorbidities: Common, Chronic, and Complex
Pharmacy Times Chronic comorbid conditions are common in adult asthma patients, and these patients need ongoing support and encouragement from health care providers including pharmacists. Adult asthma patients who suffer from comorbid chronic conditions tend to … |
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Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128.
Evid Based Complement Alternat Med. 2012;2012:769508
Authors: Kim DS, Kim SH, Kim BK, Yang MC, Ma JY
Abstract
This study was conducted to determine if oral administration of the novel herbal medicine, MA, and its Lactobacillus acidophilus fermented product, MA128, have therapeutic properties for the treatment of asthma. Asthma was induced in BALB/c mice by systemic sensitization to ovalbumin (OVA) followed by intratracheal, intraperitoneal, and aerosol allergen challenges. MA and MA128 were orally administered 6 times a week for 4 weeks. At 1 day after the last ovalbumin exposure, airway hyperresponsiveness was assessed and samples of bronchoalveolar lavage fluid, lung cells, and serum were collected for further analysis. We investigated the effect of MA and MA128 on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, OVA-specific IgE production, and Th1/Th2 cytokine production in this mouse model of asthma. In BALB/c mice, we found that MA and MA128 treatment suppressed eosinophil infiltration into airways and blood, allergic airway inflammation and AHR by suppressing the production of IL-5, IL-13, IL-17, Eotaxin, and OVA-specific IgE, by upregulating the production of OVA-specific Th1 cytokine (IFN-?), and by downregulating OVA-specific Th2 cytokine (IL-4) in the culture supernatant of spleen cells. The effectiveness of MA was increased by fermentation with Lactobacillus acidophilus.
PMID: 22203879 [PubMed – in process]
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 Daily Mail |
Complex Asthma Genes Not Useful for Setting Risk
MedPage Today Point out, however, that this study indicates that asthma is heterogeneous and that genetics likely will not be useful as predictors of disease subtypes in … Drugs 'could target asthma genes' Genetic breakthrough heralds hope of asthma cure in ten years Largest genetic study of asthma points towards better treatments |
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