Condition: Asthma
Interventions: Biological: Tralokinumab; Other: Placebo
Sponsor: AstraZeneca
Not yet recruiting – verified May 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Asthma
Interventions: Biological: Tralokinumab; Other: Placebo
Sponsor: AstraZeneca
Not yet recruiting – verified May 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Related Articles |
Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.
J Allergy Clin Immunol. 2015 Apr 9;
Authors: Persson H, Kwon AT, Ramilowski JA, Silberberg G, Söderhäll C, Orsmark-Pietras C, Nordlund B, Konradsen JR, de Hoon MJ, Melén E, Hayashizaki Y, Hedlin G, Kere J, Daub CO
Abstract
BACKGROUND: Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, such as smoking or allergies, are found after extensive investigation, these children are given a diagnosis of therapy-resistant (or therapy-refractory) asthma (SA).
OBJECTIVE: We sought to deepen our understanding of childhood SA by analyzing gene expression and modeling the underlying regulatory transcription factor networks in peripheral blood leukocytes.
METHODS: Gene expression was analyzed by using Cap Analysis of Gene Expression in children with SA (n = 13), children with controlled persistent asthma (n = 15), and age-matched healthy control subjects (n = 9). Cap Analysis of Gene Expression sequencing detects the transcription start sites of known and novel mRNAs and noncoding RNAs.
RESULTS: Sample groups could be separated by hierarchical clustering on 1305 differentially expressed transcription start sites, including 816 known genes and several novel transcripts. Ten of 13 tested novel transcripts were validated by means of RT-PCR and Sanger sequencing. Expression of RAR-related orphan receptor A (RORA), which has been linked to asthma in genome-wide association studies, was significantly upregulated in patients with SA. Gene network modeling revealed decreased glucocorticoid receptor signaling and increased activity of the mitogen-activated protein kinase and Jun kinase cascades in patients with SA.
CONCLUSION: Circulating leukocytes from children with controlled asthma and those with SA have distinct gene expression profiles, demonstrating the possible development of specific molecular biomarkers and supporting the need for novel therapeutic approaches.
PMID: 25863981 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Women with poorly controlled asthma likely to be more obese
Healio “Our study demonstrates that women with poorly controlled asthma have more severe disease and increased obesity,” researchers in Brazil wrote in Allergy, Asthma & Clinical Immunology. “The study demonstrates that there is a negative relationship … |
View full post on asthma – Google News
Tiotropium beneficial as add-on for poorly controlled asthma
Healio Gustavo J. Rodrigo, MD, of the Hospital Central de las Fuerzas Armadas in Uruguay, and a colleague reviewed 13 randomized controlled trials that included 4,966 patients to assess the efficacy and safety of tiotropium bromide in patients with asthma. |
View full post on asthma – Google News
Lung Disease News |
Patients with Asthma and Xerostomia Have Poor Levels of Controlled Disease
Lung Disease News COPD Exacerbations According to recent study, patients that suffer from asthma and a condition called xerostomia (or dry mouth syndrome), have poor levels of controlled disease. The results of the study entitled “Xerostomia relates to the degree of … |
View full post on asthma – Google News
Conditions: Rhinitis; Rhinoconjunctivitis; Asthma
Interventions: Biological: DP/MG/14-1; Biological: DP/MG/14-2
Sponsor: Laboratorios Leti, S.L.
Recruiting – verified January 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Asthma May be Controlled By Raising Vitamin D Levels in Patients
Youth Health Magzine Worsening of asthma was indicated by the number of prescriptions for asthma medicine filled and the number of physician visits. The researchers found that during the year before their first vitamin D test, 15 percent of people with readings between 0 … |
View full post on asthma – Google News
Zee News |
Asthma attacks can be controlled by Vitamin D
Zee News London: An Israeli research has found that asthma flare ups can be helpped by boosting the level of Vitamin D in deficients asthmatics. Dr Ronit Confino-Cohen from University's Sackler Faculty of Medicine, said that Vitamin D has significant … |
View full post on asthma – Google News
Adult asthma in Qatar poorly controlled despite high GDP
Healio Researchers conducted interviews in a cross-sectional study of 520 adults with physician-diagnosed asthma (58% men) from May 2011 to March 2014. Thirty-three percent of patients had uncontrolled asthma; 41%, controlled asthma; and 26%, partly … |
View full post on asthma – Google News
GPs review how well patient asthma is controlled
News-Medical.net A new Clinical e-Audit from NPS MedicineWise has been released that will help GPs review just how well patient asthma is controlled. Survey findings* released last month showed that over half of all respondents to a survey of adults with asthma said … |
View full post on asthma – Google News