Asthma Attacks Can Be Reduced When Exposure to Triggers is Controlled – Albany Times Union

Asthma Attacks Can Be Reduced When Exposure to Triggers is Controlled
Albany Times Union
Home Air Check™, the leading indoor air quality testing solution for measuring hundreds of chemical pollutants in home air, announces a simple do-it-yourself test for detecting the presence of airborne chemical irritants that can trigger asthma

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Asthma Attacks Can Be Reduced When Exposure to Triggers is Controlled – San Francisco Chronicle (press release)

Asthma Attacks Can Be Reduced When Exposure to Triggers is Controlled
San Francisco Chronicle (press release)
Home Air Check™ can help improve indoor air environments by identifying chemical pollutants that can trigger asthma attacks Mt. Pleasant, MI (PRWEB) May 18, 2012 Home Air Check™, the leading indoor air quality testing solution for measuring hundreds

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No improvement of poorly controlled child asthma symptoms with addition of … – Pediatric SuperSite


Pediatric SuperSite

No improvement of poorly controlled child asthma symptoms with addition of
Pediatric SuperSite
Adding the proton pump inhibitor lansoprazole failed to improve symptoms of poorly controlled asthma in children without gastroesophageal reflux and may actually increase adverse events, according to study results published online.

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Lansoprazole Disappoints for Poorly Controlled Asthma in Kids – Family Practice News Digital Network

Lansoprazole Disappoints for Poorly Controlled Asthma in Kids
Family Practice News Digital Network
The proton pump inhibitor lansoprazole was no better than placebo for improving symptoms and lung function in a randomized, placebo-controlled trial involving more than 300 children with poorly controlled asthma without overt gastroesophageal reflux.

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Asthma Study for African American Women Announced

Call for Participation

Clinicaltrials.gov, a service of the U.S. National Institute of Health is announcing a study protocol for Women of Color and Asthma Control: A randomized controlled trial of an asthma-management intervention for African American women

Among adults in the United States, asthma prevalence is disproportionately high among African American women; this group also experiences the highest levels of asthma-linked mortality and asthma-related health care utilization. Factors linked to biological sex (e.g ., hormonal fluctuations), gender roles (e.g ., exposure to certain triggers) and race (e.g ., inadequate access to care) all contribute to the excess asthma burden in this group, and also shape the context within which African American women manage their condition.

No prior interventions for improving asthma self-management have specifically targeted this vulnerable group of asthma patients. The current study aims to evaluate the efficacy of a culturally- and gender-relevant asthma-management intervention among African American women.

Methods: A randomized controlled trial will be used to compare a five-session asthma-management intervention with usual care.

This intervention is delivered over the telephone by a trained health educator. Intervention content is informed by the principles of self-regulation for disease management, and all program activities and materials are designed to be responsive to the specific needs of African American women.

We will recruit 420 female participants who self-identify as African American, and who have seen a clinician for persistent asthma in the last year. Half of these will receive the intervention.

The primary outcomes, upon which the target sample size is based, are number of asthma-related emergency department visits and overnight hospitalizations in the last 12 months. We will also assess the effect of the intervention on asthma symptoms and asthma-related quality of life.

Data will be collected via telephone survey and medical record review at baseline, and 12 and 24 months from baseline. DiscussionWe seek to decrease asthma-related health care utilization and improve asthma-related quality of life in African American women with asthma, by offering them a culturally- and gender-relevant program to enhance asthma management. The results of this study will provide important information about the feasibility and value of this program in helping to address persistent racial and gender disparities in asthma outcomes.Trial Registration For additional information visit: Clinicaltrials.gov NCT01117805

Helium-oxygen therapy for infants with bronchiolitis: a randomized controlled trial.

Helium-oxygen therapy for infants with bronchiolitis: a randomized controlled trial.

Arch Pediatr Adolesc Med. 2011 Dec;165(12):1115-22

Authors: Kim IK, Phrampus E, Sikes K, Pendleton J, Saville A, Corcoran T, Gracely E, Venkataraman S

Abstract
OBJECTIVE: To compare nebulized racemic epinephrine delivered by 70% helium and 30% oxygen or 100% oxygen followed by helium-oxygen inhalation therapy via high-flow nasal cannula (HFNC) vs oxygen inhalation via HFNC in the treatment of bronchiolitis.
DESIGN: Prospective, randomized, controlled, single-blind trial.
SETTING: This study was conducted from October 1, 2004, through May 31, 2008, in the emergency department of an urban, tertiary care children’s hospital. Patients  Infants aged 2 to 12 months with a Modified Wood’s Clinical Asthma Score (M-WCAS) of 3 or higher.
INTERVENTIONS: Patients initially received nebulized albuterol treatment driven by 100% oxygen. Patients were randomized to the helium-oxygen or oxygen group and received nebulized racemic epinephrine via a face mask. After nebulization, humidified helium-oxygen or oxygen was delivered by HFNC. After 60 minutes of inhalation therapy, patients with an M-WCAS of 2 or higher received a second delivery of nebulized racemic epinephrine followed by helium-oxygen or oxygen delivered by HFNC. Main Outcome Measure  Degree of improvement of M-WCAS for 240 minutes or until emergency department discharge.
RESULTS: Of 69 infants enrolled, 34 were randomized to the helium-oxygen group and 35 to the oxygen group. The mean change in M-WCAS from baseline to 240 minutes or emergency department discharge was 1.84 for the helium-oxygen group compared with 0.31 for the oxygen group (P < .001). The mean M-WCAS was significantly improved for the helium-oxygen group compared with the oxygen group at 60 minutes (P = .005), 120 minutes (P < .001), 180 minutes (P < .001), and 240 minutes (P < .001).
CONCLUSION: Nebulized racemic epinephrine delivered by helium-oxygen followed by helium-oxygen inhalation therapy delivered by HFNC was associated with a greater degree of clinical improvement compared with that delivered by oxygen among infants with bronchiolitis. Trial Registration  clinicaltrials.gov Identifier: NCT00116584.

PMID: 22147778 [PubMed – in process]

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