The dangers of widespread nitric oxide screening for primary ciliary dyskinesia.

Related Articles

The dangers of widespread nitric oxide screening for primary ciliary dyskinesia.

Thorax. 2016 Feb 19;

Authors: Collins SA, Behan L, Harris A, Gove K, Lucas JS

Abstract
Primary ciliary dyskinesia (PCD) is underdiagnosed and requires complex testing at specialist diagnostic centres. Measurement of nasal nitric oxide (nNO) has good sensitivity and specificity screening for PCD, but is currently usually measured at PCD centres rather than prior to referral. Proposals to include NO testing for asthma diagnoses could widen access to PCD screening if nasal mode analysers are available. Data from 282 consecutive referrals to our PCD diagnostic centre (31 PCD positive) were used to model predictive values for nNO testing with varying pretest probability and showed that predictive values were good in the referral population, but extending screening to more general populations would result in excessive false positives that may overwhelm diagnostic services. Although nNO remains a useful test, a ‘normal’ result with classical clinical history should still be considered for further testing.

PMID: 26896442 [PubMed – as supplied by publisher]

View full post on pubmed: asthma

Asthma sufferers and elderly warned over air pollution dangers – Belfast Telegraph


Belfast Telegraph

Asthma sufferers and elderly warned over air pollution dangers
Belfast Telegraph
Kay Boycott, chief executive of Asthma UK, said: "The two-thirds of people with asthma who find that air pollution makes their asthma worse will be at an increased risk of an attack following the alarming Defra warning of high pollution levels around
Millions warned of high pollutionCrosby Herald

all 5 news articles »

View full post on asthma – Google News

Toxic Water: Asthma And Other Health Dangers Of Swimming In Chlorinated Pools – Medical Daily

Toxic Water: Asthma And Other Health Dangers Of Swimming In Chlorinated Pools
Medical Daily
The odds of children developing asthma increases with exposure to chlorine, presumably mediated by nitrogen trichloride (NCI) (3) — a byproduct of chemical reactions between ammonia and chlorine that can damage the respiratory thin tissue in children 

View full post on asthma – Google News