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Developing better drugs for asthma and high blood pressure
EurekAlert (press release) For asthma and high blood pressure, the researchers are systematically examining the regulatory effect of small RNA (ribonucleic acid) strands. In other words, they are using bioinformatic methods to identify illness-related genes; that is, the genes … |
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Higher risk for developing zoster observed in adult patients with asthma
Healio “Consideration should be given to immunizing adults 50 years or older with asthma or atopic dermatitis as a target group for zoster vaccine.” Kwon and colleagues identified 371 patients with zoster (66% women; 94% white; mean age 66.8 ± 10.7 years) and … |
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Researchers find association between air quality and developing asthma
Healio “Our findings provide evidence for positive associations of exposure to NO2 and PM2.5 absorbance early in life with incidence and prevalence of asthma, but not rhinoconjunctivitis, throughout childhood and adolescence,” Ulrike Gehring, PhD, associate … |
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Tobacco use increases beta-agonist use, likelihood of developing asthma in …
Healio “When the mother or stepmother who lives in the child's home is a tobacco smoker, the child's history of asthma diagnosis and prescription for short acting beta-agonist medication are both increased. The increased emergency department visits for asthma … |
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Science Times |
Early Exposure to Pets Reduces Risk of Developing Asthma
Science Times Researchers determined if there is a causal relationship between respiratory disease, particularly asthma, and early exposure to animals. The group found that there is a 52 percent reduced risk for children growing with registered farm-animal workers. Owning a dog may protect your kids from an exhausting chronic disease Dogs in the home may lower kids' odds for asthma Having Ponies May Lower Children's Risk of Asthma, Study Says |
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International Business Times AU |
Children growing with dogs have lower risk of developing asthma, higher …
International Business Times AU The study, published in JAMA Pediatrics, shows that a child exposed to a dog in the first year of life has a 15 percent lower risk of having asthma in later childhood compared to children without dogs. The findings come from the analysis of the health … Children Exposed To Domestic Animals Have Lesser Risk Of Having Asthma, Study Says Decreased Asthma Risk In Children Raised With Dogs Dogs can help prevent asthma in kids |
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Can Food Allergies Put You at a Higher Risk of Developing Asthma?
Allergic Living Q: My 6-year-old son has food allergies and now also seems to be coughing a lot during the night (long after he's eaten). Could he be developing asthma? How can we know and what are the next steps? Dr. Bassett: You are right to be concerned. A history … |
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Prolonged mounted patrolling is a risk factor for developing knee pain in Danish military personnel deployed to the Helmand Province.
J R Army Med Corps. 2015 Oct 16;
Authors: Lundin CR, Houe T, Sevelsted A, Nissen L
Abstract
INTRODUCTION: Non-battle injuries have been the leading cause of medical evacuation in the recent wars in Afghanistan and Iraq. This study investigates the hypothesis, that the occurrence of knee problems could be associated with mounted patrolling in armoured vehicles independent of other risk factors.
METHOD: Retrospective questionnaire-based cohort study of Danish soldiers deployed to Afghanistan during 1 February-31 July 2013.
RESULTS: 307 soldiers included. Response rate 70%. 33% reported knee pain. Main finding: Significant association between knee pain and time spent weekly on mounted patrols (OR 1.23, CI 1.07 to 1.41, p=0.003). Controlled for confounders age, body mass index and duration of military employment (OR 1.22, CI 1.06 to 1.41, p=0.006). Adjusted for confounders and all other risk factors (OR 1.25, CI 1.07 to 1.48, p=0.007). The main finding in a subset of the 33% with knee pain: Significant association between more severe knee problems with Knee injury and Osteoarthritis Outcome Score below 400 and time spent weekly on mounted patrols (OR 1.49, CI 1.17 to 1.56, p=0.002).
CONCLUSIONS: A major concern regarding knee problems among Danish deployed military personnel is identified. The risk of suffering from knee problems and the severity of symptoms increase with the amount of time spent inside a vehicle on mounted patrols.
PMID: 26475797 [PubMed – as supplied by publisher]
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Asthma May Increase Risk of Developing Parkinson's
Psychiatry Advisor Chih-Ming Cheng, MD, from the Taipei Veterans General Hospital in Taiwan, and colleagues examined the temporal association between asthma and Parkinson's disease. A cohort of 10,455 patients (age 45 years and older) who were diagnosed with … |
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Soluble Guanylate Cyclase Modulators Blunt Hyperoxia Effects on Calcium Responses of Developing Human Airway Smooth Muscle.
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 7;:ajplung.00232.2015
Authors: Britt RD, Thompson MA, Kuipers I, Stewart A, Vogel ER, Thu J, Martin RJ, Pabelick CM, Prakash YS
Abstract
Exposure to moderate hyperoxia in prematurity contributes to subsequent airway dysfunction and increases the risk of developing recurrent wheeze and asthma. The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic GMP (cGMP) axis modulates airway tone by regulating airway smooth muscle (ASM) intracellular Ca(2+) ([Ca(2+)]i) and contractility. However, the effects of hyperoxia on this axis in the context of Ca(2+)/contractility are not known. In developing human ASM, we explored the effects of novel drugs that activate sGC independent of NO, on alleviating hyperoxia (50% oxygen)-induced enhancement of Ca(2+) responses to bronchoconstrictor agonist. Treatment with BAY 41-2272 (sGC stimulator) and BAY 60-2770 (sGC activator) increased cGMP levels during exposure to 50% O2. Although 50% O2 did not alter sGC?1 and sGC?1 expression, BAY 60-2770 did increase sGC?1 expression. BAY 41-2272 and BAY 60-2770 blunted Ca(2+) responses to histamine in cells exposed to 50% O2. The effects of BAY 41-2272 and BAY 60-2770 were reversed by protein kinase G inhibition. These novel data demonstrate that BAY 41-2272 and BAY 60-2770 stimulate production of cGMP and blunt hyperoxia-induced increases in Ca(2+) responses in developing ASM. Accordingly, sGC stimulators/activators may be a useful therapeutic strategy in improving bronchodilation in preterm infants.
PMID: 26254425 [PubMed – as supplied by publisher]
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