Breathe Well Live Well
|
Diverse Asthma Treatment Pipeline Presents Major Investment Opportunity, says …
Drug Discovery & Development The company's latest report* states that while asthma therapy development is dominated by small molecule compounds, with 156 products representing 67% of the pipeline, the research and development landscape has moved towards biologics on an … |
View full post on asthma – Google News
| Related Articles |
Evolution of exhaled nitric oxide levels throughout development and aging of healthy humans.
J Breath Res. 2015;9(3):036005
Authors: Jacinto T, Malinovschi A, Janson C, Fonseca J, Alving K
Abstract
It is not fully understood how the fraction of exhaled nitric oxide (FeNO) varies with age and gender in healthy individuals. We aim to describe the evolution of FeNO with age, giving special regard to the effect of gender, and to relate this evolution to natural changes in the respiratory tract.We studied 3081 subjects from NHANES 2007-08 and 2009-10, aged 6-80?years, with no self-reported diagnosis of asthma, chronic bronchitis or emphysema, and with normal values of blood eosinophils and C-reactive protein. The relationship of the mean values of FeNO to age, in all participants and divided by gender, was computed, and compared with changes in anatomic dead space volume and forced vital capacity. A change-point analysis technique and subsequent piecewise regression was used to detect breakpoints in the evolution of FeNO with age.Three distinct phases in the evolution of FeNO throughout the age range 6-80?years can be seen. FeNO values increase linearly between 6-14?years of age in girls and between 6-16?years of age in boys, in parallel with somatic growth. After that, FeNO levels plateau in both genders until age 45?years in females and age 59?years in males, when they start to increase linearly again. This increase continues until age 80.Our data clearly show a triphasic evolution of FeNO throughout the human age range in healthy individuals. This should be accounted for in development of reference equations for normal FeNO values.
PMID: 25993061 [PubMed – in process]
View full post on pubmed: asthma
|
Drug Target for Asthma Discovered
Drug Discovery & Development The over-active immune cells responsible for asthma depend on the gene BCL11B to develop into mature cells, according to a study published in the Journal of Experimental Medicine. The identification of this gene's role could help in the search for … |
View full post on asthma – Google News
Drug Discovery & Development |
Progress Towards a New Asthma Treatment
Drug Discovery & Development Source: University of Queensland University of Queensland researchers are developing a new asthma treatment that targets the underlying cause of asthma, rather than just the symptoms. Asthma affects one in 10 Australians and is the most common chronic … |
View full post on asthma – Google News
| Related Articles |
Exposure to Indoor Pollutants and Wheeze and Asthma Development during Early Childhood.
Int J Environ Res Public Health. 2015;12(4):3993-4017
Authors: Patelarou E, Tzanakis N, Kelly FJ
Abstract
BACKGROUND: This review aimed to summarize existing epidemiological evidence of the association between quantitative estimates of indoor air pollution with early childhood respiratory disease.
METHODS: We carried out a systematic literature search of peer-reviewed epidemiological studies undertaken in “westernized” countries that have assessed exposure to indoor pollutants and asthma and wheeze from infancy up to the age of 5.
RESULTS: The search, between January 2004 and February 2014 yielded 1840 studies for consideration. Following application of eligibility criteria to titles and abstracts 22 independent studies were deemed relevant for further review. Two additional studies were next identified through examination of the references’ lists of these studies. Of these 24 selected studies, 16 adopted a prospective cohort design and 8 were case-control studies. Fourteen studies assessed exposure to bio-aerosols, 8 studies assessed exposure to specific air chemicals and two studies assessed exposure to bio-aerosols and air chemicals. Furthermore, 11 studies examined the association of exposure with asthma and 16 with wheeze. Findings indicate that existing studies have reported contradictory effects of indoor pollutants levels and occurrence of asthma/wheeze.
CONCLUSION: Additional research to establish causality and evaluate interventions to prevent disease onset is needed.
PMID: 25872014 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
HCPLive |
Psychedelic Drug Prevents Asthma Development
HCPLive These drugs, while their neurological effects have been researched extensively, identified its role in asthma development—a discovery, lead researcher Charles Nichols, PhD, an Associate Professor of Pharmacology and Experimental Therapeutics at the … |
View full post on asthma – Google News
|
Scientists Identify Receptor for Asthma Associated Virus
Drug Discovery & Development Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have identified a cellular receptor for rhinovirus C, a cold-causing virus that is strongly associated with severe asthma … |
View full post on asthma – Google News
Health Aim |
CCL28 Protein Linked To Development Of Asthma
Health Aim Asthma is not an unknown disease to anyone now. In all our gathering there is someone or another who is suffering from asthma. It is estimated that around 300 million people worldwide suffer from asthma. In a very recent study published in the Journal … Protein linked to development of asthma paves way for novel therapy Public Release: 20-Feb-2015 Protein linked to development of asthma Researchers identify protein linked to asthma |
View full post on asthma – Google News
Zee News |
CCL28 protein linked to development of asthma
Science Codex Researchers have linked a specific protein to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral asthma in young children. Asthma is a … Public Release: 20-Feb-2015 Protein linked to development of asthma Protein tied to asthma identified |
View full post on asthma – Google News
|
Public Release: 20-Feb-2015 Protein linked to development of asthma
EurekAlert (press release) Researchers at the Medical College of Wisconsin (MCW) have linked a specific protein to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral … |
View full post on asthma – Google News