Utah Department of Health: Asthma, Mental Illnesses Are Directly Correlated – Parent Herald


Parent Herald

Utah Department of Health: Asthma, Mental Illnesses Are Directly Correlated
Parent Herald
In a recent interview with Fox 13, Utah epidemiologist Holly Uphold said there has been enough evidence to conclude that asthma and depression are directly correlated. For one, approximately 36 percent of asthmatic adults in Utah are also having bouts

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Childhood exposure to paracetamol not directly associated with increased … – 2 Minute Medicine


2 Minute Medicine

Childhood exposure to paracetamol not directly associated with increased
2 Minute Medicine
1. This meta-analysis could not conclusively attribute increased asthma risk to in utero or early life paracetamol exposure. 2. While initial analysis showed an association between paracetamol exposure and asthma risk, controlling for coincident upper …

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Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions.

Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions.

Pharmacol Rev. 2013;65(2):670-709

Authors: Schmidt M, Dekker FJ, Maarsingh H

Abstract
Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal and versatile second messengers. The tremendous feature of cAMP to tightly control highly diverse physiologic processes, including calcium homeostasis, metabolism, secretion, muscle contraction, cell fate, and gene transcription, is reflected by the award of five Nobel prizes. The discovery of Epac (exchange protein directly activated by cAMP) has ignited a new surge of cAMP-related research and has depicted novel cAMP properties independent of protein kinase A and cyclic nucleotide-gated channels. The multidomain architecture of Epac determines its activity state and allows cell-type specific protein-protein and protein-lipid interactions that control fine-tuning of pivotal biologic responses through the “old” second messenger cAMP. Compartmentalization of cAMP in space and time, maintained by A-kinase anchoring proteins, phosphodiesterases, and ?-arrestins, contributes to the Epac signalosome of small GTPases, phospholipases, mitogen- and lipid-activated kinases, and transcription factors. These novel cAMP sensors seem to implement certain unexpected signaling properties of cAMP and thereby to permit delicate adaptations of biologic responses. Agonists and antagonists selective for Epac are developed and will support further studies on the biologic net outcome of the activation of Epac. This will increase our current knowledge on the pathophysiology of devastating diseases, such as diabetes, cognitive impairment, renal and heart failure, (pulmonary) hypertension, asthma, and chronic obstructive pulmonary disease. Further insights into the cAMP dynamics executed by the Epac signalosome will help to optimize the pharmacological treatment of these diseases.

PMID: 23447132 [PubMed – as supplied by publisher]

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