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Biologics for asthma: Attacking the source of the disease, not the symptoms
Science Codex SAN ANTONIO, TX (November 5, 2015) – Imagine you suffer from severe asthma, and you've tried every treatment available, but nothing has worked. You still can't breathe. Then a new therapy comes along that attacks the source of the asthma, as opposed to … Kids with asthma can avoid the ER by avoiding the ER Breast is Best, but Might Not Protect from Allergies |
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Tech Insider (blog) |
Owning a dog may protect your kids from an exhausting chronic disease
Tech Insider (blog) Children who grow up with dogs may be 15% less likely to develop asthma than kids who don't, according to a new study published Nov. 2 in the journal JAMA Pediatrics. Early exposures to farm animals, the study also found, add some immune-boosting … Exposure to animals tied to lower asthma rates in children Decreased Asthma Risk In Children Raised With Dogs Children Exposed To Domestic Animals Have Lesser Risk Of Having Asthma, Study Says |
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Lung Disease News |
Potential Asthma Drug OATD-01 Selected as First OncoArendi Therapeutics …
Lung Disease News AMCases are present in the human genome and have been found to be over-expressed and play a role in the Th2-specific and interleukin-13 –mediated pathway in pulmonary epithelial cells in human asthma. Neutralization of AMCase has been shown to … |
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Study Finds That Daily Exercise Relieves Asthma Symptoms
Lung Disease News Physical activity has been shown to offer various health benefits for patients with asthma, especially in children. However, there is still limited data on the nature of the association between physical activity and asthma control in adults. Results … |
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Therapeutic potential of soluble guanylate cyclase modulators in neonatal chronic lung disease.
Am J Physiol Lung Cell Mol Physiol. 2015 Oct 2;:ajplung.00333.2015
Authors: Wagenaar GT, Hiemstra PS, Gosens R
Abstract
Supplemental oxygen after premature birth results in aberrant airway, alveolar and pulmonary vascular development with an increased risk for bronchopulmonary dysplasia (BPD), and development of wheeze and asthma, pulmonary hypertension and COPD in survivors. Although stimulation of the nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic GMP (cGMP) signal transduction pathway has significant beneficial effects on disease development in animal models, so far this could not be translated to the clinic. Oxidative stress reduces the NO-sGC-cGMP pathway by oxidizing heme-bound sGC, resulting in inactivation or degradation of sGC. Reduced sGC activity and/or expression is associated with pathology due to premature birth, oxidative stress-induced lung injury, including impaired alveolar maturation, smooth muscle cell (SMC) proliferation and contraction, impaired airway relaxation and vasodilation, inflammation, pulmonary hypertension, right ventricular hypertrophy and an aggravated response towards hyperoxia-induced neonatal lung injury. Recently, Britt et al. (10) demonstrated that histamine-induced Ca2+ responses were significantly elevated in hyperoxia-exposed fetal human airway SMC’s compared to normoxic controls, and that this hyperoxia-induced increase in the response was strongly reduced by NO-independent stimulation and activation of sGC. These recent studies highlight the therapeutic potential of sGC modulators in the treatment of preterm infants for respiratory distress with supplemental oxygen. Such treatment is aimed at improving aberrant alveolar and vascular development of the neonatal lung, and preventing the development of wheezing and asthma in survivors of premature birth. In addition, these studies highlight the suitability of fetal human airway SMC’s as a translational model for pathological airway changes in the neonate.
PMID: 26432873 [PubMed – as supplied by publisher]
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Lung Disease News |
Study Determines Individuals with Asthma at Increased Risk for Parkinson's …
Lung Disease News In the study entitled “Risk of developing Parkinson's disease among patients with asthma: a nationwide longitudinal study,” Chih-Ming Cheng, MD, of the department of psychiatry at Taipei Veterans General Hospital in Taipei, Taiwan and colleagues used … |
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Study Reveals Factors indicating Better Clinical Outcomes in Asthma Patients
Lung Disease News For asthma patients, not all inhaler devices are created alike. Satisfaction with their inhaler was just one of several factors that predicted a positive outcome in asthma patients, according to a recent study by David Price, MD at the University of … |
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Researchers identify link between asthma, Parkinson's disease
Healio Researchers also reported a dose-dependent relationship between greater asthma severity and higher risk for Parkinson's disease. Chih-Ming Cheng, MD, of the department of psychiatry at Taipei Veterans General Hospital in Taipei, Taiwan, and colleagues … |
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Lung Disease News |
Discovered Mechanism Underlying “Farm Dust” Could Lead To Protection Against …
Lung Disease News While known for many years that children growing up on farms were more protected from asthma, no conclusive scientific findings could support this hypothesis until now. To uncover the connection between the exposure to farm dust and protection against … Allergy Study Could Lead To Asthma Prevention Treatment Farm kids less likely to have asthma Farm dust protects against allergies? |
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Roflumilast Reduces Airway Inflammation in Asthma Patients
Lung Disease News Inhaled corticosteroids (ICS) are recommended as the most effective treatment for asthma – ICS acts by reducing inflammation in lungs' airways and sputum production via the bronchial tubes – but their prolonged use is associated with both local and … |
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